sodium-ethylxanthate and Liver-Neoplasms

Nonalcoholic fatty liver disease (NAFLD) is considered to be a disease of obese individuals, yet lean patients are increasingly susceptible to have NAFLD. The aim of this study was to evaluate the profile of nonobese patients by comparing with obese NAFLD patients.. We have included 465 patients of NAFLD after exclusion of other diseases, and 220 with elevated alanine aminotransferase (ALT) were biopsied. Patients were biochemically and clinically evaluated: blood pressure, body mass index (BMI), and waist circumference (WC) were recorded for every patient. A BMI  ≥ 25 kg/m(2) was defined as obese, and those with a BMI of <25 kg/m(2) were labeled as nonobese. Histological activity was expressed with NAFLD activity score (NAS).. Of 465 cases, 119 (25.6 %) were nonobese. Diabetes was noted in 122 (26.2 %) and hypertension in 122 (26.2 %). Metabolic syndrome was present in 253 (59.7 %), low HDL cholesterol in 228 (64.8 %), hypertriglyceridemia in 297 (73.2 %), and WC above normal in 308 (70.2 %). Males were predominating in the nonobese compared to females in the obese (p = 0.001). Hypertriglyceridemia and low high-density lipoprotein was similar in the obese and nonobese (76.2 % vs. 72.3 %, p = 0.5 and 65.2 % vs. 64.6 %, p = 1.0, respectively). The grades of steatosis, lobular inflammation, ballooning, NAS, and the stage of fibrosis did not also significantly differ between obese and nonobese patients. Nonalcoholic steatohepatitis (NASH) was 53.1 % in nonobese.. Nonobese was 25.6 % among NAFLD patients of Bangladesh, and 53.1 % of nonobese NAFLD cases were NASH. Though they were nonobese by BMI grade, they were metabolically similar to obese. Males were predominant in the nonobese, whereas females in the obese. NASH and fibrosis were similar in the obese and nonobese.

Topics: Adult; Bangladesh; Body Mass Index; Carcinoma, Hepatocellular; Disease Progression; Female; Humans; Insulin Resistance; Liver; Liver Cirrhosis; Liver Neoplasms; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Obesity; Sex

By clarifying the natural history of chronic hepatitis B, to evaluate its long-term therapeutic outcome, antiviral drugs efficacy and economic significance.. A cohort of 183 (mean age of 31.75?.03 years, male/female ratio: 152:31) chronic hepatitis B patients with biopsy-proven and 247 cases of general population as control were followed up by retrospective cohort study. The follow-up time was 11.81?.08 years. This study was focused on long-term clinical outcome including the rate of liver cirrhosis, hepatocellular carcinoma and death, the long-term effect of antiviral drugs and prognostic factors.. In chronic hepatitis B patients, 22 (12.02%) developed liver cirrhosis, 12 (6.56%) hepatocellular carcinoma, and 20 (10.93%) died. The cumulative survival probabilities were 97.27%, 91.62%, and 84.47% in 5, 10, and 15 years, respectively. The cumulative probabilities of HCC were 0.00%, 3.19%, and 11.56% in 5, 10, and 15 years, respectively. In 247 control subjects, 6 (2.43%) died, none of them developed cirrhosis or HCC. The rates of death, liver cirrhosis, and HCC in hepatitis B patients were markedly different (P<0.005) compared with controls. The overall mortality of hepatitis B patients was 4.50 folds of the general population. Cox multiple regression analysis showed that old age, severe histological injury, and the positive HBeAg were closely related to liver cirrhosis, while old age, severe histological injury, and male were major factors leading to death. The independent variable of predicted HCC was not found.. The long-term outcome of hepatitis B is poor.

Topics: Adolescent; Adult; Aging; Carcinoma, Hepatocellular; Cohort Studies; Female; Follow-Up Studies; Hepatitis B e Antigens; Hepatitis B, Chronic; Humans; Liver Cirrhosis; Liver Failure; Liver Neoplasms; Male; Middle Aged; Regression Analysis; Retrospective Studies; Risk Factors; Sex; Survival Rate

We performed a case-control study to evaluate the risk of hepatocellular carcinoma (HCC) for hepatitis C virus (HCV) infection. A total of 305 newly diagnosed HCC cases (80% males) and 610 subjects (81% males) unaffected by clinically evident hepatic disease admitted to the 2 main hospitals in Brescia, North Italy, were recruited as cases and controls, respectively. Among the 122 HCC cases positive for HCV RNA, genotype 1b was found in 83 patients (68%), genotype 2 in 36 (29.5%) and genotype 1a in 3 (2.5%). Among the controls, 15 were infected with genotype 1b and 15 with type 2. Analysis of HCV envelope 1 nucleotide sequence among 25 cases and 8 controls infected with genotype 2 showed subtype 2c in 96% of cases and in all controls, and subtype 2a in 1 HCC case. The odds ratio (OR) for HCV RNA positivity adjusted for hepatitis B virus (HBV) markers and alcohol intake was 26.3 [95% confidence interval (CI): 15.8-44], and it was higher for genotype 1b (OR = 34.2) than type 2 (OR = 14.4). The OR for HCV RNA was 35.6 (95% CI: 14.5-87.1) when the HBV markers were all negative and 132 (15.3-890) when HBsAg positivity was present; the OR was 26.1 (95% CI: 12.6-54.0) among subjects with alcohol intake of 0-40 g/day and increased to 62.6 (23.3-168) and 126 (42.8-373) with an alcohol intake of 41-80 and >80 g/day, respectively. In conclusion, synergism was found between HCV infection and HBV infection and alcohol intake in causing HCC.

Topics: Adult; Age Factors; Aged; Alcohol Drinking; Antibodies, Viral; Antigens, Viral; Carcinoma, Hepatocellular; Case-Control Studies; Female; Genotype; Hepacivirus; Hepatitis B; Hepatitis B virus; Hepatitis C; Humans; Liver Neoplasms; Male; Middle Aged; Odds Ratio; Risk Factors; RNA, Viral; Seroepidemiologic Studies; Sex

Palpable subcutaneous transplants of hepatocellular carcinoma-35 appeared slightly earlier in male animals; however, the number of successful growths was no greater than that in female animals. Castration and administration of testosterone or diethylstilbestrol were performed after the transplants reached 1.0-1.5 cm in size. The carcinoma was less well differentiated histologically, had more bile pigment, grew rapidly, mestastasized sooner and killed the host quickly in castrated females given testosterone propionate. Bile was present in lung metastases. There was little difference in the growth rate in intact or castrated male or female animals. Exogenous diethylstilbestrol slowed the growth of the transplants and cause weight loss in castrated males. The weight loss was felt to be related to extensive necrosis of the carcinoma.

Topics: Animals; Carcinoma, Hepatocellular; Castration; Cell Differentiation; Diethylstilbestrol; Female; Gonadal Steroid Hormones; Liver Neoplasms; Male; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Rats; Sex; Testosterone

Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Female; Hyperplasia; Injections, Subcutaneous; Liver Neoplasms; Male; Neoplasms, Experimental; Rats; Sex

Topics: Adolescent; Adult; Aged; Aging; Carcinoma; Carcinoma, Hepatocellular; Child; Female; Hemoglobinometry; Humans; Leukocyte Count; Liver Function Tests; Liver Neoplasms; Male; Middle Aged; Sex; Taiwan

Topics: Animals; Body Weight; Carcinoma, Hepatocellular; Cytogenetics; Genes; Liver Neoplasms; Mice; Oncogenic Viruses; Sex

Topics: Animals; Autoradiography; Carcinoma, Hepatocellular; Castration; Cell Division; DNA, Neoplasm; Estrogens; In Vitro Techniques; Liver Neoplasms; Mice; Sex; Testosterone

Topics: Biliary Tract; Bronchial Neoplasms; Esophageal Neoplasms; Ethnology; Gastrointestinal Neoplasms; Humans; Intestinal Neoplasms; Leukemia; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Rectal Neoplasms; Sex; Stomach Neoplasms

Topics: Aging; Burkitt Lymphoma; Gastrointestinal Neoplasms; Humans; Laryngeal Neoplasms; Liver Neoplasms; Lung Neoplasms; Lymphoma; Male; Mozambique; Neoplasms; Paranasal Sinus Neoplasms; Penile Neoplasms; Sex; Urinary Bladder Neoplasms

Topics: Aging; Anemia; Blood Sedimentation; Body Temperature; Gastrointestinal Hemorrhage; Genetics, Medical; Hematology; Hemochromatosis; Hepatomegaly; Hypoglycemia; Iron; Liver; Liver Cirrhosis; Liver Neoplasms; Neoplasm Metastasis; Neoplasms; Pleural Effusion; Sex; Splenomegaly

Topics: Androgens; Carcinoma, Hepatocellular; Liver Cirrhosis; Liver Neoplasms; Neoplasms; Neoplasms, Experimental; Rats; Research; Sex

Topics: Abdominal Neoplasms; Adolescent; Aging; Brain Neoplasms; Child; Classification; Eye Neoplasms; Humans; Infant; Infant, Newborn; Leukemia; Liver Neoplasms; Lymphoma; Mediastinal Neoplasms; Neoplasms; Retroperitoneal Neoplasms; Sex

Topics: Carcinoma, Hepatocellular; Geriatrics; Hemochromatosis; Humans; Liver Cirrhosis; Liver Neoplasms; Neoplasms; Sex