sodium-ethylxanthate and Leukemia

Among the neurological side-effects, peripheral neuropathy is a result of therapy with vindesine and above all vincristine. Although in most cases it is responsible only for paresthesias, it may cause extensive paralysis and requires that the drug be discontinued. These drugs may also affect the neurovegetative system. Ototoxicity may be seen with cis-platinum and vigilance disturbances with L-asparaginase. Genetic consequences are mainly due to alkylating agents. These agents almost constantly impair male and female fertility but recovery is possible. Libido is also affected with the attendant psychological consequences. The offspring of patients previously treated by chemotherapeutic agents are normal. Development of secondary carcinoma or leukemia is currently a major concern. Secondary malignant disease may develop after the treatment of any cancer, especially if radiotherapy was associated with alkylating agents. Leukemias are of the acute myeloid type and usually follow a preleukemic phase. A table summarizes the main toxicities of the most usual drugs.

Topics: Antineoplastic Agents; Brain Diseases; Fertility; Humans; Leukemia; Neoplasms; Sex

Topics: Carcinogenesis; Chromosomes; Leukemia; Leukemia, Radiation-Induced; Mice; Neoplasms; Neoplasms, Radiation-Induced; Oncogenic Viruses; Physiology; Radiation, Ionizing; Rats; Research; Sex; Toxicology

Topics: Chromosome Aberrations; Chromosome Disorders; Humans; Leukemia; Sex

Topics: Aged; Bioethics; Delivery of Health Care; Dissent and Disputes; Female; Homicide; Humans; Infant, Newborn; Leukemia; Male; Massachusetts; Persons with Mental Disabilities; Sex; Sex Offenses

Thirty-eight sex-mismatched bone marrow transplantation patients with various hematological diseases were followed-up using fluorescence in situ hybridization. Probes specific for various translocations, the X chromosome (DXZ1) and the whole Y chromosome (WCP Y), were used to assess successful engraftment and residual host cells. The combination of translocation and WCP Y probes enabled the identification of host and donor cells in addition to the identification of malignant vs. normal cells in the transplant recipient. Fifteen patients were sequentially followed up. The results obtained using the combination of translocation plus WCP Y probes were more reliable than those with DXZ1 plus WCP Y probes, or the translocation probe alone, especially when the percentage of residual leukemic cells detected by the translocation probe alone was around the cut-off level.

Topics: Bone Marrow Transplantation; Chimera; Chromosome Aberrations; Chromosome Disorders; DNA Probes; DNA, Neoplasm; Female; Humans; In Situ Hybridization, Fluorescence; Leukemia; Male; Neoplasm, Residual; Sex; Translocation, Genetic

Topics: Adolescent; Adult; Aged; Aging; Antigens; Child; Child, Preschool; Computers; Factor Analysis, Statistical; Female; Hepatitis; Humans; Immunodiffusion; Infant; Leprosy; Leukemia; Male; Middle Aged; Philippines; Sex

Topics: Adolescent; Aging; Bone Neoplasms; Burkitt Lymphoma; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Leukemia; Lymphoma; Male; Melanoma; Neoplasms; Neoplasms, Connective Tissue; Neoplasms, Germ Cell and Embryonal; Neoplasms, Glandular and Epithelial; Neoplasms, Nerve Tissue; Sarcoma; Sex; Uganda; United States

Topics: Adolescent; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Japan; Leukemia; Leukemia, Lymphoid; Leukemia, Radiation-Induced; Male; Nuclear Warfare; Retrospective Studies; Sex

Topics: Biliary Tract; Bronchial Neoplasms; Esophageal Neoplasms; Ethnology; Gastrointestinal Neoplasms; Humans; Intestinal Neoplasms; Leukemia; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Rectal Neoplasms; Sex; Stomach Neoplasms

Study of the death certificates of 876 spouses of widows and widowers who died of leukemia revealed that seven of the spouses also died of leukemia. However, five cases of leukemia were identified among matched controls of the spouses. The incidence of leukemia in husbands and wives of individuals who die of leukemia is not significantly greater than that of a control group. This is consistent with the hypothesis that adult leukemia is not contagious in the usual sense.

Topics: Adult; Communicable Diseases; Ethnology; Female; Humans; Incidence; Leukemia; Male; Marriage; Neoplasms; New York; Sex; Spouses

Topics: Adolescent; Aging; Bone Neoplasms; Brain Neoplasms; Child; Ethnology; Geography; Humans; Infant; Kidney Neoplasms; Leukemia; Lymphoma; Mortality; Neoplasms; Sex; United States

Topics: Adult; Aged; Aging; England; Female; Humans; Leukemia; Male; Middle Aged; Mortality; Phosphorus Isotopes; Polycythemia Vera; Prognosis; Sex

Topics: Aging; Arteriosclerosis; Asthma; Blindness; Dementia; Emphysema; Geriatrics; Hexosamines; Humans; Hypertension; Leukemia; Lung Neoplasms; Lymphogranuloma Venereum; Male; Neoplasms; Prostatic Hyperplasia; Psychotic Disorders; Scoliosis; Sex; Stomach Neoplasms; Stomach Ulcer; Urine

Topics: Animals; Bone Marrow; Injections; Injections, Intraperitoneal; Leukemia; Leukemia, Experimental; Leukemia, Radiation-Induced; Mice; Mice, Inbred C57BL; Research; Sex; Urethane

Topics: Adolescent; Altitude; Female; Geriatrics; Humans; Leukemia; Lung Neoplasms; Lymphoma; Neoplasms; Peru; Sex; Stomach Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms

Topics: Child; Chromosome Aberrations; Chromosome Disorders; Female; Fetal Death; Genetics, Medical; Humans; Infant; Infant, Newborn; Leukemia; Maternal-Fetal Exchange; Mothers; Pregnancy; Pregnancy Complications, Hematologic; Radiation Genetics; Sex; Sex Ratio; Statistics as Topic

Topics: Abdominal Neoplasms; Adolescent; Aging; Brain Neoplasms; Child; Classification; Eye Neoplasms; Humans; Infant; Infant, Newborn; Leukemia; Liver Neoplasms; Lymphoma; Mediastinal Neoplasms; Neoplasms; Retroperitoneal Neoplasms; Sex

Topics: Animals; Bone Marrow Transplantation; Hydrocortisone; Leukemia; Leukemia, Lymphoid; Leukemia, Radiation-Induced; Lymphocytes; Mice; Mice, Inbred AKR; Pharmacology; Research; Sex; Toxicology

Topics: Animals; Carcinogens; Female; Fetus; Leukemia; Leukemia, Experimental; Leukemia, Radiation-Induced; Mice; Phosphorus; Phosphorus Isotopes; Pregnancy; Radiation; Research; Sex

Topics: Animals; Antibodies; Antigens; Chromosomes; Genetics; Hemagglutination; Histocompatibility Antigens; Leukemia; Leukemia, Experimental; Mice; Neoplasm Transplantation; Neoplasms; Research; Sex; Transplantation Immunology

Topics: Adolescent; Biometry; Child; England; Geriatrics; Humans; Infant; Leukemia; Mortality; Neoplasms; Sex; United States; Wales

Topics: Adolescent; Antineoplastic Agents; Child; Denmark; Drug Therapy; Finland; France; Geriatrics; Hormones; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Neoplasms; Norway; Sex; Survival Rate; United States

Topics: Adolescent; Aging; Blood Protein Electrophoresis; Child; Humans; Infant; Leukemia; Lipoproteins; Serum; Sex