sodium-ethylxanthate and Drug-Related-Side-Effects-and-Adverse-Reactions

Topics: Age Factors; Anxiety; Culture; Disease; Drive; Drug-Related Side Effects and Adverse Reactions; Erectile Dysfunction; Fear; Genetics, Behavioral; Hostility; Humans; Male; Mythology; Personality; Psychophysiologic Disorders; Psychotic Disorders; Research; Sex; Sex Education; Statistics as Topic; Superstitions

Without an understanding of the developmental factors which initiate functional changes in the adolescent's capacity for drug disposition, the choice of any developmental measure (e.g., Tanner staging) to include in a focused research effort is premature. The role of growth and gender in pubertal functional change must be delineated. In addition, research must target clinically relevant pharmacokinetic changes resulting from this functional development and relate these to modifications of drug effect (i.e., using effect-controlled trials rather than concentration-controlled trials). Such studies could define population characteristics associated with pubertal development that produce pharmacodynamic changes. Drug effect in the adolescent, particularly at the receptor level, needs study. A strategy for the systematic evaluation of these issues is discussed.

Topics: Adolescent; Adolescent Behavior; Clinical Trials as Topic; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Pharmacokinetics; Pharmacology; Puberty; Research; Research Design; Sex

Counseling for the resumption of sexual activity deserves as much attention in a cardiac rehabilitation program as walking or jogging. Research findings enable the counselor to give specific sexual advice. The energey expenditure during coitus for long-married couples is equivalent to that of climbing stairs, and consequently the risk of heart attack is low. However, clustering of psychosocial and physiologic demands, such as illicit affairs, outbursts of anger, alcohol, and hearty meals, may precipitate reinfarction or death. A sexual activities program is successful only if each partner is committed to give and receive pleasure. Knowledgeable and sensitive counseling will enable the couple to explore extra-coital options for lovemaking prior to the resumption of intercourse. This writer has observed that once couples are "turned on" to the pleasuring exercises, coital activity is attempted at an earlier date without untoward side effects in the cardiac patient.

Topics: Aging; Coitus; Counseling; Depression; Drug-Related Side Effects and Adverse Reactions; Energy Metabolism; Female; Heart; Heart Diseases; Humans; Libido; Male; Marriage; Masturbation; Middle Aged; Myocardial Infarction; Posture; Sex; Sexual Behavior