sodium-ethylxanthate and Diabetic-Retinopathy

In a population-based study in southern Wisconsin, 996 insulin-taking, younger-onset diabetic persons were examined using standard protocols to determine the prevalence and severity of diabetic retinopathy and associated risk variables. The prevalence of diabetic retinopathy varied from 17% to 97.5% in persons with diabetes for less than five years and 15 or more years, respectively. Proliferative retinopathy varied from 1.2% to 67% in persons with diabetes for less than ten years and 35 or more years, respectively. For persons with diabetes of 10 years' duration or less, the Cox regression model relates the severity or retinopathy to longer duration, older age at examination, and higher levels of glycosylated hemoglobin. After ten years of diabetes, severity of retinopathy was related to longer duration, high levels of glycosylated hemoglobin, presence of proteinuria, higher diastolic BP, and male sex.

Topics: Adolescent; Adult; Age Factors; Blood Pressure; Body Weight; Child; Diabetes Mellitus; Diabetic Retinopathy; Epidemiologic Methods; Female; Glycated Hemoglobin; Humans; Insulin; Male; Risk; Sex; Time Factors; Wisconsin

In a population-based study in southern Wisconsin, 1,370 patients given diagnoses of diabetes at age 30 years or older were examined using standard protocols to determine the prevalence and severity of diabetic retinopathy and associated risk variables. The prevalence of diabetic retinopathy varied from 28.8% in persons who had diabetes for less than five years to 77.8% in persons who had diabetes for 15 or more years. The rate of proliferative diabetic retinopathy varied from 2.0% in persons who had diabetes for less than five years to 15.5% in persons who had diabetes for 15 or more years. By using the Cox regression model, the severity of retinopathy was found to be related to longer duration of diabetes, younger age at diagnosis, higher glycosylated hemoglobin levels, higher systolic BP, use of insulin, presence of proteinuria, and small body mass.

Topics: Aged; Blood Pressure; Body Weight; Diabetes Mellitus; Diabetic Retinopathy; Epidemiologic Methods; Female; Glycated Hemoglobin; Humans; Insulin; Male; Middle Aged; Risk; Sex; Time Factors; Wisconsin

Topics: Adipose Tissue; Adult; Aged; Alanine Transaminase; Anthropometry; Blood Glucose; Blood Pressure; Body Weight; Calcinosis; Carbohydrates; Clinical Laboratory Techniques; Diabetes Complications; Diabetes Mellitus; Diabetic Retinopathy; Female; Humans; Insulin; Leg; Male; Middle Aged; Neurologic Manifestations; Pulse; Sex; Sweden; Vascular Diseases

Topics: 17-Ketosteroids; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Black People; Diabetes Mellitus; Diabetic Retinopathy; Humans; Research; Sex; Urine; White People