sodium-ethylxanthate and Dermatitis

sodium-ethylxanthate has been researched along with Dermatitis* in 4 studies

Trials

1 trial(s) available for sodium-ethylxanthate and Dermatitis

Article	Year
Deficiency of glutathione S-transferases T1 and M1 as heritable factors of increased cutaneous UV sensitivity. The Journal of investigative dermatology, 1997, Volume: 108, Issue:2 Glutathione S-transferases (GSTs) play a primary role in cellular defense against electrophilic chemical species and radical oxygen species. Because free radical attack is one mechanism of UV irradiation-caused skin damage, we investigated whether genetic variation at the GST loci GST T1 and GST M1 influences individual UVB sensitivity. In a double-blind clinical trial, 50 healthy volunteers were evaluated for minimal erythema dose of UVB irradiation, MED (J/cm2), skin types were assigned, and internal standard-controlled polymerase chain reaction (PCR) was used to identify their GST T1 and GST M1 genotypes. The five homozygous carriers of the GST T1 deletion (GST T10/0) presented with the most intensive inflammatory reactions after irradiation; they were significantly overrepresented among the highly UVB-sensitive subgroups (p = 0.006). Lack of GST M1 (GST M10/0, n = 27) tended to be more frequent only in UVB-sensitive subjects, and the proportion of the active GST M1 allelic variants A and B was similar in all UVB sensitivity subgroups. Three subjects with deficiencies in GST T1 and GST M1 had the most intense inflammatory responses. No effect of gender or genetic variations at the MC1R gene locus was established. Thus, heritable GST T1 deficiency may be a genetic determinant of individual skin sensitivity toward UV irradiation. Topics: Adult; Dermatitis; Double-Blind Method; Erythema; Female; Genotype; Glutathione Transferase; Heterozygote; Humans; Male; Receptors, Pituitary Hormone; Sex; Ultraviolet Rays	1997

Article

Year

Deficiency of glutathione S-transferases T1 and M1 as heritable factors of increased cutaneous UV sensitivity.

The Journal of investigative dermatology, 1997, Volume: 108, Issue:2

Glutathione S-transferases (GSTs) play a primary role in cellular defense against electrophilic chemical species and radical oxygen species. Because free radical attack is one mechanism of UV irradiation-caused skin damage, we investigated whether genetic variation at the GST loci GST T1 and GST M1 influences individual UVB sensitivity. In a double-blind clinical trial, 50 healthy volunteers were evaluated for minimal erythema dose of UVB irradiation, MED (J/cm2), skin types were assigned, and internal standard-controlled polymerase chain reaction (PCR) was used to identify their GST T1 and GST M1 genotypes. The five homozygous carriers of the GST T1 deletion (GST T1*0/0) presented with the most intensive inflammatory reactions after irradiation; they were significantly overrepresented among the highly UVB-sensitive subgroups (p = 0.006). Lack of GST M1 (GST M1*0/0, n = 27) tended to be more frequent only in UVB-sensitive subjects, and the proportion of the active GST M1 allelic variants *A and *B was similar in all UVB sensitivity subgroups. Three subjects with deficiencies in GST T1 and GST M1 had the most intense inflammatory responses. No effect of gender or genetic variations at the MC1R gene locus was established. Thus, heritable GST T1 deficiency may be a genetic determinant of individual skin sensitivity toward UV irradiation.

Topics: Adult; Dermatitis; Double-Blind Method; Erythema; Female; Genotype; Glutathione Transferase; Heterozygote; Humans; Male; Receptors, Pituitary Hormone; Sex; Ultraviolet Rays

1997

Other Studies

3 other study(ies) available for sodium-ethylxanthate and Dermatitis

Article	Year
EFFECTS ON RATS OF VARYING DIETARY CORN OIL IN CONJUNCTION WITH FEEDING 20,25-DIAZA-CHOLESTEROL. Life sciences (1962), 1965, Volume: 4 Topics: Alopecia; Cholesterol; Corn Oil; Dermatitis; Dietary Fats; Dietary Fats, Unsaturated; Growth; Lipid Metabolism; Neurologic Manifestations; Oils; Rats; Research; Sex; Sterols	1965
ALLERGIC DISEASES IN ADOLESCENTS. I. DESCRIPTION OF SURVEY; PREVALENCE OF ALLERGY. American journal of diseases of children (1960), 1964, Volume: 107 Topics: Adolescent; Asthma; Colorado; Dermatitis; Dermatitis, Atopic; Health Surveys; Humans; Hypersensitivity; Hypersensitivity, Immediate; Prevalence; Rhinitis, Allergic, Seasonal; School Health Services; Sex; Social Conditions; Statistics as Topic; Urticaria	1964
[Changes in the sexual order and the constancy of sex offenses]. Zeitschrift fur Haut- und Geschlechtskrankheiten, 1951, Jul-15, Volume: 11, Issue:2 Topics: Dermatitis; Dermatitis, Exfoliative; Humans; Jurisprudence; Sex; Sex Offenses; Sexual Behavior	1951