sodium-ethylxanthate and Colonic-Neoplasms

Studies of gender differences in colorectal cancer have shown temporal shifts in incidence and site distribution which can be attributed, in part, to environmental and behavioural factors. In high-risk populations, rectal cancer and left-sided colon cancer have been more frequent in older men, whereas right-sided colon cancer has been more commonly found in older women. Among known associations with reduced colorectal cancer risk, women appear to ingest more dietary fibre, seem to benefit more from physical activity and body mass, and consume less alcohol. Although these differences may contribute to the risk differential, hormonal events during reproductive years also appear to affect women's risk at older age. The interactions of sex hormone metabolism and nutrition, including dietary fibre, in colorectal carcinogenesis provide a rewarding field for investigation.

Topics: Colonic Neoplasms; Female; Humans; Male; Rectal Neoplasms; Sex; Sex Characteristics; Sex Factors

Topics: Adult; Aged; Black or African American; Colonic Neoplasms; Ethnology; Female; Humans; Injections, Intraperitoneal; Injections, Intravenous; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Postoperative Complications; Rectal Neoplasms; Sex; Thiotepa; White People

Topics: Adult; Colonic Neoplasms; Estrogens; Female; Humans; Insulin; Insulin-Like Growth Factor I; Male; Menopause; Middle Aged; Obesity; Risk Factors; Sex

Correlation coefficients for age-standardized incidence rates between cancers of the stomach, colon, rectum and lung over place (worldwide) and time (in Connecticut) vary from positive to negative values, indicating that these cancers are not caused by common environmental agents. Correlation coefficients for age-incidence patterns (the variation in age-specific rates with age) between these cancers, on the other hand, are all highly positive for both sexes. We conclude that the carcinogenic determinants that vary with age are common to the cancers studied and to both sexes, and distinct from the carcinogenic determinants that vary with place and time. For the cancers studied, incidence rates are negligible until age 30, at which time they increase dramatically and continue to increase at least until age 75. The rate of increase, however, diminishes continuously with advancing age after 30. We suggest that the role of aging in cancer incidence is determined by two components, one responsible for the dramatic rate increase beginning near age 30 and one responsible for the gradual diminution in that rate increase. The former may correspond to the activation of quiescent cells with damaged DNA or to the deactivation of DNA surveillance or repair or to impaired apoptosis, while the latter may correspond to the loss of cell division potential.

Topics: Adult; Aged; Aging; Colonic Neoplasms; Environment; Female; Humans; Incidence; Lung Neoplasms; Male; Middle Aged; Rectal Neoplasms; Registries; Sex; Sex Factors; Stomach Neoplasms; Time Factors

Topics: Adult; Aged; Colonic Neoplasms; Esophageal Neoplasms; Ethnology; Female; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Rectal Neoplasms; Sex; Stomach Neoplasms

Topics: Adult; Aged; Blood Group Antigens; Colonic Neoplasms; Denmark; Esophageal Neoplasms; Female; Finland; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Norway; Rectal Neoplasms; Sex; Smoking; Stomach Neoplasms; Sweden

Topics: Adult; Aged; Colonic Neoplasms; Esophageal Neoplasms; Female; Gastrointestinal Neoplasms; Humans; Iceland; Male; Middle Aged; Rectal Neoplasms; Sex; Stomach Neoplasms

Topics: Adolescent; Adult; Aged; Child; Colonic Neoplasms; Egypt; Esophageal Neoplasms; Female; Gastrointestinal Neoplasms; Humans; Intestinal Neoplasms; Intestine, Small; Male; Middle Aged; Mouth Neoplasms; Rectal Neoplasms; Sex; Stomach Neoplasms

Topics: Adolescent; Adult; Aged; Bolivia; Brazil; California; Chile; Colombia; Colonic Neoplasms; England; Esophageal Neoplasms; Female; Gastrointestinal Neoplasms; Humans; Intestinal Neoplasms; Male; Middle Aged; Rectal Neoplasms; Sampling Studies; Sex; Stomach Neoplasms; Venezuela

Topics: Adult; Aged; Aging; Cathartics; Colonic Neoplasms; Constipation; Defecation; Enema; Environment; Female; Hospitalization; Humans; Longevity; Male; Middle Aged; Occupations; Rectal Neoplasms; Religion; Retrospective Studies; Sex; Smoking; Statistics as Topic

Topics: Adenocarcinoma, Mucinous; Adult; Aged; Black or African American; Black People; Colonic Neoplasms; Esophageal Neoplasms; Female; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Nitrosamines; Rectal Neoplasms; Sex; South Africa; Stomach Neoplasms

Topics: Colonic Neoplasms; Connecticut; Denmark; England; Finland; Neoplasms; Norway; Rectal Neoplasms; Rectum; Sex; Surgical Procedures, Operative; United States; Wales

Topics: Aging; Colonic Neoplasms; Italy; Neoplasms; Pathology; Rectal Neoplasms; Rectum; Sex; Surgical Procedures, Operative