sodium-ethylxanthate and Carcinoma--Squamous-Cell

Population demographics, risk behaviors, and compliance rates for the management of an ASCUS (atypical squamous cells of undetermined significance) diagnosis are not well studied in the adolescent population. From June 1994 to December 1996, 1,175 Papanicalou (pap) smears were performed in an urban adolescent clinic on patients age 12 to 18. Of these, 124 (10.5%) were diagnosed with ASCUS or ASCUS with a qualifying statement. A retrospective chart review (n=83) and telephone interview was performed on patients with ASCUS. Ninety-nine percent of enrollees were African American. Comparisons were made between those patients with normal pap smears and those with ASCUS. No statistically significant difference existed pertaining to age at pap smear, age at menarche, age at first coitus, and education level. A positive association was found in the ASCUS group for the presence of sexually transmitted diseases (P < 0.001), number of sexual partners (P < 0.0007), and pregnancy (P < 0.001). Of the 80% of patients who had an ASCUS diagnosis and were referred for colposcopy (n = 62), only 61% attended their appointment (n = 38). Thirty-nine percent of these patients were aware of an abnormal diagnosis after colposcopy. For those that attended colposcopy, 56% were accompanied by a parent. For those who were not compliant with attendance, none cited parental consent for the procedure as a barrier to obtaining treatment. Adolescent females in an urban setting with multiple sexual partners, history of sexually transmitted diseases, and prior pregnancy are at a greater risk for ASCUS on cervicovaginal smear when compared to their age-matched controls. In addition, the adolescent compliance rate for colposcopy is low. We, therefore, recommend that these adolescent females be observed diligently.

Topics: Adolescent; Adult; Carcinoma, Squamous Cell; Child; Colposcopy; Contraceptives, Oral; Female; Humans; Papanicolaou Test; Risk Factors; Sex; Sexually Transmitted Diseases; Treatment Refusal; Uterine Cervical Dysplasia; Vaginal Smears

A case-control study of 418 women with invasive squamous cell cervical cancer and 704 population controls enabled evaluation of risk factors for this relatively rare cancer. Consistent with an infectious etiology was a pronounced effect of multiple sexual partners, with those reporting 10 or more partners being at a significant threefold excess risk. Early first intercourse also was associated with some residual effect on risk, although the relationship was not linear, nor the explanation readily apparent. Those with multiple births were at significantly elevated risks, even after adjustment for sexual parameters. Menstrual and hygiene factors, including use of tampons, vaginal deodorants, and douching products, were not consistently related to risk. Histories of specific infections involving the genital tract were poor predictors of risk, since few women provided positive responses, but those with nonspecific diseases were at a significant twofold excess risk.

Topics: Adult; Aged; Carcinoma, Squamous Cell; Demography; Female; Genital Diseases, Female; Humans; Infections; Middle Aged; Parity; Risk; Sex; United States; Uterine Cervical Neoplasms

A case-control study among white women in Los Angeles County was conducted to investigate etiologic factors that might explain the high rates of invasive cervical cancer among Latinas. Two hundred patients with invasive squamous cell carcinoma of the uterine cervix and matched (age, sex, preferred language, and neighborhood) controls were interviewed, 98 pairs in English and 102 pairs in Spanish. Seven factors were found to contribute independently and significantly (P less than .01) to risk, each after adjustment for the other six: years since last Pap smear, years of education (protective), frequency-years douching, pack-years of smoking, years of barrier contraceptive use (protective), number of sexual partners before age 20, and recognized episodes of genital warts. An eighth variable, interval in years between menarche and first intercourse, was the second variable to enter the stepwise logistic regression analysis but lost its statistical significance when sexual partners before age 20 entered the model. Together, these eight variables accounted for almost 99% of the risk. There were no significant interactions between any of these variables and age, language of interview, or birth in a Latin country. There was no increased risk associated with use of oral contraceptives, either before or after adjustment for the other significant factors. Compared to English-speaking controls, Spanish-speaking controls smoked less, douched less, had fewer sexual partners before 20, and had essentially the same average interval between menarche and first intercourse and the same average number of episodes of genital warts; however, they had had a longer interval since their last Pap smear, fewer years of barrier contraceptive use, and fewer years of education. Education, presumably a correlate of an inadequately measured etiologic risk factor (possibly papillomavirus infection), was responsible for the greatest difference in risk between the Spanish- and English-speaking cases.

Topics: Adolescent; Adult; Aged; California; Carcinoma, Squamous Cell; Contraception; Female; Genital Diseases, Female; Hispanic or Latino; Humans; Middle Aged; Risk; Sex; Smoking; Socioeconomic Factors; Therapeutic Irrigation; Uterine Cervical Neoplasms

Hibernating European hamsters reacted differently to sc injections of N-nitrosodiethylamine (DEN) than did European hamsters that were not hibernating. Hibernating animals tolerated higher dose levels but developed fewer neoplasms. In contrast, hibernating males had more pulmonary tumors than did the respective nonhibernators. However, the hibernating females of the low dosage group developed fewer lung tumors. The survival times were longer for the male hibernators than for the male nonhibernators. The organ specificity of DEN, as well as the morphology and histogenesis of the neoplasms, showed no differences between the hibernating and nonhibernating groups.

Topics: Adenocarcinoma; Animals; Basement Membrane; Carcinoma, Squamous Cell; Cricetinae; Diethylnitrosamine; Female; Hibernation; Lethal Dose 50; Lung Neoplasms; Male; Neoplasms, Experimental; Nitrosamines; Nose Neoplasms; Papilloma; Sex; Species Specificity

Topics: Adult; Aged; Carcinoma, Squamous Cell; Female; Humans; Lymphatic Metastasis; Male; Michigan; Middle Aged; Neck Dissection; Sex; Tongue Neoplasms

Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aging; Australia; Carcinoma; Carcinoma, Squamous Cell; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Lung Neoplasms; Lymphatic Metastasis; Male; Mass Screening; Middle Aged; Radiography; Sex

Topics: Adenocarcinoma, Mucinous; Adolescent; Adult; Aged; Carcinoma, Squamous Cell; Child; Female; Humans; Male; Middle Aged; Mouth Neoplasms; Neoplasm Metastasis; Osteoradionecrosis; Prognosis; Puerto Rico; Radiotherapy; Sex

Topics: Adult; Aged; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Egypt; Female; Fibrosarcoma; Humans; Lip Neoplasms; Male; Middle Aged; Mouth Neoplasms; Neoplasm Metastasis; Palatal Neoplasms; Sex; Tongue Neoplasms

Topics: Adenocarcinoma; Aged; Carcinoma, Basal Cell; Carcinoma, Basosquamous; Carcinoma, Squamous Cell; Female; Fibrosarcoma; Humans; Male; Middle Aged; Mortality; Neurilemmoma; Nose Neoplasms; Sex; Skin Neoplasms; Surgery, Plastic

Topics: Adenocarcinoma; Asian People; Black People; Carcinoma; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Chordoma; Ethnology; Geriatrics; Lymphatic Metastasis; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Nasopharyngeal Neoplasms; Neoplasms; New York; Rhabdomyosarcoma; Sarcoma; Sex; Surgical Procedures, Operative

Topics: Adenocarcinoma; Adolescent; Carcinoma; Carcinoma, Squamous Cell; Ethnology; Fibrosarcoma; Geriatrics; Head and Neck Neoplasms; Lymphatic Metastasis; Lymphoma; Nasopharyngeal Neoplasms; Neoplasms; Plasmacytoma; Radiotherapy Dosage; Sex; Texas

Topics: Bronchial Neoplasms; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Female; Germany; Germany, West; Humans; Lung Neoplasms; Neoplasms; Sex; Smoking

Topics: Adult; Aged; Aging; Bronchial Neoplasms; Carcinoma, Squamous Cell; Female; Head; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasms, Multiple Primary; Sex

Topics: Canada; Carcinoma; Carcinoma, Squamous Cell; Geriatrics; Humans; Lip Neoplasms; Lymph Node Excision; Neoplasm Metastasis; Neoplasms; Sex

Topics: Adenocarcinoma; Aging; Air Pollution; Bronchial Neoplasms; Carcinoma; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Germany; Germany, West; Humans; Neoplasms; Occupations; Sex; Smoking

Topics: Aging; Anxiety; Carcinoma, Squamous Cell; Humans; Lichen Planus; Mucous Membrane; Nails; Neoplasms; Psychology; Sex; Skin Neoplasms; Statistics as Topic

Topics: Aging; Animals; Brain Abscess; Brain Neoplasms; Carcinoma, Squamous Cell; Glioblastoma; Glioma; Methylcholanthrene; Mice; Neoplasms; Neoplasms, Experimental; Research; Sarcoma; Sarcoma, Experimental; Sex; Sex Factors; Toxicology

Topics: Adenocarcinoma; Antineoplastic Agents; Bronchi; Bronchial Neoplasms; Carcinoma; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Connecticut; Geriatrics; Lung Neoplasms; Neoplasms; Sex; Surgical Procedures, Operative

Topics: Adenocarcinoma; Adolescent; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Carcinosarcoma; Child; Ethnology; Geriatrics; Humans; Incidence; Kidney; Neoplasm Metastasis; Neoplasms; Pathology; Sarcoma; Sex; Singapore; Wilms Tumor

Topics: Carcinoma; Carcinoma, Squamous Cell; Humans; Neoplasm Metastasis; Neoplasms; Norway; Radium; Sex; Tongue; Tongue Neoplasms

Topics: Adenocarcinoma; Adenoma, Pleomorphic; Bronchial Neoplasms; Carcinoid Tumor; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Chondroma; Fibroma; Fibrosarcoma; Hemangiosarcoma; Humans; Leiomyoma; Leiomyosarcoma; Liposarcoma; Lung Neoplasms; Mesenchymoma; Neoplasm Metastasis; Neoplasms; Osteoma; Prognosis; Respiratory System; Respiratory Tract Neoplasms; Sex; Statistics as Topic

Topics: Adenocarcinoma; Bronchial Neoplasms; Carcinoma; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Female; Humans; Sex; Smoking; Statistics as Topic

Topics: Adenocarcinoma; Aging; Carcinoma; Carcinoma, Squamous Cell; Classification; Gastrectomy; Geriatrics; Humans; Japan; Neoplasm Metastasis; Neoplasms, Second Primary; Pathology; Sex; Stomach Neoplasms