sodium-ethylxanthate and Arthritis--Rheumatoid

Topics: Adolescent; Adult; Arthritis, Rheumatoid; Asthma; Cardiovascular Diseases; Coitus; Counseling; Diabetes Complications; Disabled Persons; Erectile Dysfunction; Female; Humans; Kidney Diseases; Lung Diseases, Obstructive; Male; Pregnancy; Sex; Sexual Dysfunction, Physiological; Spinal Cord Injuries

To define the frequency of the exon 6 tumor necrosis factor-alpha (TNF-alpha) receptor II (TNFRII) gene polymorphism in severe and mild-moderate rheumatoid arthritis (RA) and its possible influence on anti-TNF-alpha treatment responsiveness.. Two cohorts of patients with RA, the first (n = 97) defined as methotrexate responders (MTX-R) with mild-moderate synovitis, and the second (n = 78) defined as nonresponders to combination therapy and receiving anti-TNF-alpha treatment because of their severe and aggressive disease (TNF-T), were studied retrospectively and compared to age, sex, and ethnically matched controls (n = 84). In the prospective study, 66 patients with severe RA were followed over the first 6 months of anti-TNF-alpha therapy and their response was examined according to genotype.. We observed a trend towards an increased frequency of the GG genotype in patients with severe RA (6.4%) in comparison with patients with mild-moderate disease (3.1%) and controls (1.2%). When looking at the response to anti-TNF-alpha therapy, we observed that after 12 weeks of treatment, 37.8% of the TT versus 10.7% of the TG/GG patients passed from high to medium-low disease activity (p = 0.03).. In our cohorts of patients selected by response to the conventional therapy and by disease severity, our preliminary study results showed a trend towards a higher prevalence of the GG genotype for the exon 6 TNFRII polymorphism in the less responsive patients with more aggressive disease. We also found a lower degree of response to anti-TNF-alpha treatments in patients carrying the G allele.

Topics: Adult; Age Distribution; Aged; Aged, 80 and over; Antigens, CD; Arthritis, Rheumatoid; Case-Control Studies; Drug Therapy, Combination; Female; Genetic Predisposition to Disease; Genotype; Humans; Incidence; Italy; Male; Methotrexate; Middle Aged; Odds Ratio; Pharmacogenetics; Polymorphism, Genetic; Prednisone; Probability; Prognosis; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type II; Reference Values; Retrospective Studies; Risk Factors; Severity of Illness Index; Sex; Sex Distribution; Treatment Outcome

To evaluate the relative contribution of gender-related work conditions, gender-related socialization practices, and disease characteristics to the explanation of emotional distress in men and women with rheumatoid arthritis (RA).. Three hundred sixty-nine RA patients who were employed outside the home were recruited from a national randomized sample of rheumatology practices. Data on paid work and disease characteristics were obtained by telephone interview. Emotional distress was measured by the Center for Epidemiological Studies Depression (CES-D) scale. Hierarchical ordinary least-squares regression was used to assess the relationship of sex, class, work characteristics, and disease characteristics to both the CES-D summary scale and the CES-D factor structure.. Differences in emotional distress were explained best by functional ability and pain and secondarily by the characteristics of paid work, with no independent effect for sex. Distress increased with decreasing functional ability, increasing pain, and exposure to such work characteristics as low autonomy, low income, and high demands. No sex differences in any of the CES-D subscales remained after controlling for disease and work variables.. Among employed RA patients with high levels of functional disability and exposure to stressful work characteristics, men and women are at equal risk of experiencing emotional distress.

Topics: Adult; Affective Symptoms; Arthritis, Rheumatoid; Female; Humans; Longitudinal Studies; Male; Middle Aged; Sex; Socioeconomic Factors; Work

The influence of arthritis upon sexual satisfaction and activity and patient receptivity to sexual rehabilitation was investigated by interviewing 169 patients with arthritis and 130 controls. Patients differed from controls in their greater loss of sexual satisfaction over time, but they were comparably satisfied with their current sexual adjustment. They reported similar reductions in frequency of intercourse over time. Joint symptoms and fatigue disturbed the sexual adjustment of patients more than controls, but damaged body image, worry about partner interest, loss of libido and loss of lubrication did not. There was receptivity to a program of sexual rehabilitation among patients and controls that was not dependent upon sexual dissatisfaction.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arthritis; Arthritis, Rheumatoid; Female; Humans; Male; Marriage; Middle Aged; Osteoarthritis; Patient Acceptance of Health Care; Quality of Life; Sex; Spondylitis, Ankylosing

Topics: Arthritis, Rheumatoid; Carpal Tunnel Syndrome; Female; Finger Joint; Follow-Up Studies; Functional Laterality; Humans; Male; Middle Aged; Neck; Osteoarthritis; Sex; Spondylitis, Ankylosing; Tenosynovitis

Topics: Adolescent; Adult; Aged; Aging; Arthritis, Rheumatoid; Education; Female; Health Surveys; Humans; Male; Marriage; Middle Aged; Occupations; Osteoarthritis; Sex; United States

Topics: Adolescent; Adult; Aged; Agglutination Tests; Aging; Arthritis, Rheumatoid; Ethnology; Female; Humans; Israel; Male; Middle Aged; Radiography; Sex; Societies, Medical; Statistics as Topic; Surveys and Questionnaires; United States

Topics: Adult; Aged; Arthritis, Rheumatoid; Female; Genetics, Population; Health Surveys; Humans; Indians, North American; Male; Middle Aged; Rheumatoid Factor; Sex; United States

Topics: Adolescent; Adult; Aged; Aging; Arthritis, Rheumatoid; Egypt; Female; Humans; Male; Middle Aged; Psoriasis; Sex

Topics: Adult; Aged; Aging; Arthritis, Rheumatoid; Bronchiectasis; Bronchitis; Chronic Disease; Female; Humans; Male; Middle Aged; Pneumonia; Retrospective Studies; Sex; Smoking

Topics: Aged; Arthritis, Rheumatoid; Blood Sedimentation; Female; Hemoglobinometry; Humans; Leukocyte Count; Male; Minnesota; Neoplasms; Retrospective Studies; Sex

Topics: Adult; Aged; Alaska; Arthritis, Rheumatoid; Blood Glucose; Body Weight; Diabetes Mellitus; Female; Follow-Up Studies; Glucose Tolerance Test; Humans; Inuit; Male; Mass Screening; Middle Aged; Pregnancy; Pregnancy in Diabetics; Schizophrenia; Sex; Tolbutamide; United States

Topics: Adult; Aging; Arthritis, Rheumatoid; Female; gamma-Globulins; Humans; Immunoelectrophoresis; Male; Middle Aged; Rheumatoid Factor; Sex

Topics: Aged; Agglutination Tests; Antibodies, Anti-Idiotypic; Antibodies, Antinuclear; Arthritis, Rheumatoid; Autoantibodies; Blood Proteins; Female; Humans; Latex Fixation Tests; Male; Serum Albumin; Sex

Topics: Adolescent; Adult; Antibodies, Anti-Idiotypic; Aortic Arch Syndromes; Aortic Coarctation; Aortography; Arteriosclerosis Obliterans; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Child; Female; Hemagglutination Tests; Humans; Male; Middle Aged; Morbidity; Sex

Topics: Adolescent; Adult; Aged; Aging; Arthritis, Rheumatoid; England; Epidemiologic Methods; Female; Hemagglutination Tests; Humans; Intervertebral Disc Displacement; Latex Fixation Tests; Male; Middle Aged; Osteoarthritis; Rheumatoid Factor; Rural Health; Sex

Topics: Adult; Aged; Aging; Animals; Arthritis, Rheumatoid; Collagen; Elasticity; Female; Humans; In Vitro Techniques; Male; Middle Aged; Protein Deficiency; Rabbits; Rheology; Sex; Skin; Skin Physiological Phenomena

Topics: Aging; Arthritis; Arthritis, Rheumatoid; Colitis; Colitis, Ulcerative; Humans; Pathology; Sacroiliac Joint; Serologic Tests; Sex; Spondylitis; Spondylitis, Ankylosing; Statistics as Topic

Topics: Arthritis; Arthritis, Rheumatoid; Blood; Chondroma; Humans; Iron; Joint Diseases; Myositis; Rheumatic Fever; Sex; Spondylitis; Spondylitis, Ankylosing; Statistics as Topic; Transferrin

Topics: Adolescent; Adrenal Cortex Hormones; Arthritis; Arthritis, Rheumatoid; Atrophy; Biopsy; Drug Therapy; Humans; Injections, Intradermal; Pathology; Prednisolone; Sex; Skin Diseases; Tenosynovitis; Toxicology; Triamcinolone

Topics: Adult; Aging; Arthritis, Rheumatoid; Female; Humans; Intelligence; Male; Middle Aged; MMPI; Multiple Sclerosis; Neurotic Disorders; Psychological Tests; Psychology; Sex; Spinal Cord Injuries

Topics: Adrenal Glands; Aging; Arthritis, Rheumatoid; Gonadal Steroid Hormones; Humans; Neurology; Pituitary Gland; Sex

Topics: Adolescent; Aging; Arthritis; Arthritis, Juvenile; Arthritis, Reactive; Arthritis, Rheumatoid; Colitis; Colitis, Ulcerative; Humans; Osteoporosis; Psoriasis; Rheumatic Diseases; Sex; Spinal Diseases; Spondylitis; Spondylitis, Ankylosing

Topics: Aging; Arthritis; Arthritis, Rheumatoid; Black People; Female; Humans; Latex Fixation Tests; Pregnancy; Rheumatoid Factor; Sex; Statistics as Topic; Virginia; White People

Topics: Arthritis; Arthritis, Rheumatoid; Communication; Epidemiology; Humans; Rheumatic Diseases; Sex; Sweden

Topics: Achlorhydria; Arthritis; Arthritis, Rheumatoid; Deglutition Disorders; Esophagus; Humans; Radiography; Sex; Sjogren's Syndrome; Xerostomia

Topics: Adolescent; Aging; Antistreptolysin; Antitoxins; Arthritis; Arthritis, Juvenile; Arthritis, Rheumatoid; Blood Protein Electrophoresis; Blood Sedimentation; Child; Clinical Laboratory Techniques; gamma-Globulins; Hemagglutination; Hemagglutination Tests; Hemoglobinometry; Humans; Hyaluronoglucosaminidase; Infant; Latex Fixation Tests; Rheumatic Fever; Sex; Toxins, Biological

Topics: Adolescent; Arthritis; Arthritis, Rheumatoid; Biopsy; Child; Diagnosis; Geriatrics; Humans; Pathology; Psoriasis; Sex; Synovitis

Topics: Adolescent; Aging; Arthritis; Arthritis, Rheumatoid; Geriatrics; Hemolysin Proteins; Humans; Immunoglobulins; Liver Cirrhosis; Lupus Erythematosus, Systemic; Scleroderma, Systemic; Sex; Staphylococcus