sodium-ethylxanthate and Arteriosclerosis

This study investigated in prepubertal obese children (POC), compared with prepubertal lean children (PLC), a possible relation among plasma total homocysteine (tHcy)-an independent risk factor for future atherosclerosis-and MCP-1 and RANTES, two circulating chemokines inducing leukocyte transendothelial migration (TEM), implicated in the initial stages of the inflammatory part of the atherosclerotic process. Seventy-two POC were evaluated for circulating tHcy, MCP-1, and RANTES, and compared with 42 healthy PLC. The mean adjusted (for age, sex as well as log10total insulin, vitB12, folate, total cholesterol, HDL cholesterol, log10triglycerides, and log10glucose levels) differences in tHcy, MCP-1, and RANTES levels between PLC and POC were all significant [1.16 nmol/mL (P = 0.03), 26.6 pg/mL (P = 0.02), and 52.9 pg/mL (P = 0.03), respectively]. In PLC, but not in POC, tHcy levels were negatively associated with both circulating MCP-1 (B = -1.68, P = 0.007) and RANTES (B = -1.16, P = 0.01) after adjusting for age, sex, BMI, as well as log10total insulin, vitB12, folate, total cholesterol, HDL cholesterol, log10triglycerides, and log10glucose levels. In conclusion, in POC there is a lack, in contrast to PLC, of a possibly autoregulatory, negative association of elevated tHcy levels to increased MCP-1 and RANTES levels. This could contribute to future, homocysteine-induced atherosclerosis.

Topics: Arteriosclerosis; Blood Glucose; Body Mass Index; Body Weight; Chemokine CCL2; Chemokine CCL5; Chemotaxis, Leukocyte; Child; Cholesterol, HDL; Data Interpretation, Statistical; Endothelium, Vascular; Female; Folic Acid; Homocysteine; Humans; Insulin; Male; Obesity; Puberty; Sex; Thinness; Triglycerides; Vitamin B 12

Topics: Arteriosclerosis; Autonomic Nervous System; Cardiovascular Diseases; Coronary Vessels; Endothelium, Vascular; Female; Humans; Hypertension; Male; Myocardium; Renin-Angiotensin System; Risk Factors; Sex

Male, nonarteriosclerotic (virgin) intact and castrated, Sprague-Dawley rats and male, arteriosclerotic (breeder) rats were subjected to an acute and massive myocardial infarct, by treating them with two large, subcutaneous doses of isoproterenol, spaced 24 hr apart. Serum insulin and glucose rose abruptly after the first injection of isoproterenol, but not after the second injection. Free fatty acids rose, most markedly, in the intact, nonarteriosclerotic rats, less in the arteriosclerotic breeders, and least in the castrates. These changes in free fatty acids coincided with numerical survival, i.e., greatest number of survivors in castrates. The castrated males also manifested the least amount of congestive heart failure and showed the greatest capacity to affect myocardial repair. It is suggested that reduced androgen levels may have an ameliorative effect on the usual pathogenesis of isoproterenol-induced myocardial infarction in rats.

Topics: Animals; Arteriosclerosis; Blood Glucose; Castration; Fatty Acids, Nonesterified; Insulin; Isoproterenol; Male; Myocardial Infarction; Myocardium; Rats; Sex; Testis

Topics: Anticholesteremic Agents; Arteriosclerosis; Estrogens; Humans; Hypertension; Sex

Topics: Adult; Arteriosclerosis; Black or African American; Blood Donors; Cholesterol; Ethnology; Female; Glycerides; Gout; Humans; Intracranial Embolism and Thrombosis; Male; Middle Aged; Myocardial Infarction; Obesity; Retrospective Studies; Sex; Triglycerides; Uric Acid; White People

Topics: Animals; Arteriosclerosis; Behavior, Animal; Coronary Disease; Diazepam; Female; Male; Myocardium; Necrosis; Poultry; Sex

Topics: Aging; Animals; Aorta, Thoracic; Arteriosclerosis; Body Weight; Cholesterol; Coronary Vessels; Dietary Fats; Dietary Proteins; Haplorhini; In Vitro Techniques; Sex

Topics: Adolescent; Adult; Aged; Aging; Aorta; Aortic Diseases; Arteriosclerosis; Brachiocephalic Trunk; Carotid Arteries; Child; Child, Preschool; Coronary Disease; Coronary Vessels; Female; Humans; Iliac Artery; India; Male; Middle Aged; Sex

Topics: Adolescent; Adult; Aged; Aging; Angina Pectoris; Aortic Diseases; Arteries; Arteriosclerosis; Cholesterol; Coronary Disease; Female; Humans; Intracranial Arteriosclerosis; Male; Middle Aged; Myocardial Infarction; Phospholipids; Sex; Thrombosis

Topics: Adult; Aged; Aging; Aorta, Abdominal; Arteries; Arteriosclerosis; Calcium; Coronary Vessels; Female; Humans; Male; Middle Aged; Pulmonary Artery; Radioactivity; Sex

Topics: Adolescent; Adult; Aged; Aging; Aorta; Arteriosclerosis; Body Weight; Calcinosis; Cerebral Arteries; Cholesterol; Coronary Vessels; Female; Heart Diseases; Humans; Hypertension; Lipids; Male; Middle Aged; Nutritional Physiological Phenomena; Phospholipids; Sex

Topics: Arteriosclerosis; Diet, Atherogenic; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Europe; Fats, Unsaturated; Female; Humans; Male; Nutrition Surveys; Sex

Topics: Adolescent; Adult; Aged; Arteriosclerosis; Calcification, Physiologic; Cartilage; Female; Humans; Male; Middle Aged; Radiography, Thoracic; Ribs; Sex

Topics: Adult; Aged; Arteriosclerosis; Female; Glaucoma; Humans; Male; Middle Aged; Retinal Vessels; Sex; Thrombophlebitis; Thrombosis

Topics: Aorta; Arteriosclerosis; Atherosclerosis; Blood Pressure; Blood Pressure Determination; Carotid Arteries; Cerebral Arteries; Coronary Vessels; Geriatrics; Humans; Hypertension; Middle Aged; Sex; Statistics as Topic; Vertebral Artery

Topics: Alcoholic Beverages; Arteriosclerosis; Aspirin; Blood Group Antigens; Duodenal Ulcer; Genetics, Medical; Heart Diseases; Hematemesis; Humans; Hypertension; Infections; Melena; Peptic Ulcer Hemorrhage; Sex; Smoking; Statistics as Topic; Stress, Physiological

Topics: Aortic Diseases; Arteriosclerosis; Atherosclerosis; Coronary Disease; Geriatrics; Neoplasms; Sex; Statistics as Topic; Syndrome

Topics: Aging; Aortic Diseases; Arteriosclerosis; Atherosclerosis; Coronary Disease; Geriatrics; Lipid Metabolism; Nutrition Disorders; Sex; Statistics as Topic

Topics: Aging; Arteriosclerosis; Atherosclerosis; Ethnology; Humans; Life Expectancy; Mortality; Scotland; Sex; Statistics as Topic; United Kingdom

Topics: Adult; Aged; Arteriosclerosis; Coronary Disease; Epidemiologic Methods; Epidemiology; Female; Humans; Intracranial Arteriosclerosis; Male; Middle Aged; Mortality; Sex

Topics: Aging; Animals; Aortic Diseases; Argentina; Arteriosclerosis; Body Weight; Diet; Female; Gonads; Growth; Histocytochemistry; In Vitro Techniques; Male; Monkey Diseases; Sex; Tooth Eruption

Topics: Adult; Aged; Aging; Arteriosclerosis; Black or African American; Calcinosis; Coronary Disease; Female; Geography; Humans; Louisiana; Male; Middle Aged; Sex

Topics: Adolescent; Adult; Aged; Aging; Arteriosclerosis; Blood Pressure Determination; Blood Volume Determination; Body Weight; Child; Female; Heart Function Tests; Humans; Male; Middle Aged; Pulse; Sex

Topics: Adolescent; Adult; Aged; Aging; Aorta; Aortic Diseases; Arteriosclerosis; Cholesterol; Female; Histocytochemistry; Humans; Male; Middle Aged; Phospholipids; Sex; Statistics as Topic

Topics: Adolescent; Adult; Aged; Aging; Arteriosclerosis; Cholesterol; Coronary Disease; Female; Histocytochemistry; Humans; Male; Middle Aged; Phospholipids; Sex; Statistics as Topic

Topics: Adult; Arteriosclerosis; Electrocardiography; Female; Humans; Male; Middle Aged; Physical Exertion; Pulse; Sex

Topics: Adolescent; Aging; Arteriosclerosis; Blood Circulation; Blood Pressure Determination; Blood Volume Determination; Child; Child, Preschool; Female; Heart Failure; Heart Function Tests; Humans; Hypertension; Kidney Diseases; Male; Middle Aged; Pulse; Sex

Topics: Aging; Aorta; Aorta, Abdominal; Aorta, Thoracic; Aortic Diseases; Aortic Valve; Arteriosclerosis; Calcification, Physiologic; Geriatrics; Humans; Male; Sex; Statistics as Topic; Tissue Culture Techniques

Topics: Aging; Arteriosclerosis; Asthma; Blindness; Dementia; Emphysema; Geriatrics; Hexosamines; Humans; Hypertension; Leukemia; Lung Neoplasms; Lymphogranuloma Venereum; Male; Neoplasms; Prostatic Hyperplasia; Psychotic Disorders; Scoliosis; Sex; Stomach Neoplasms; Stomach Ulcer; Urine

Topics: Aging; Arteriosclerosis; Brazil; Centrifugation; Chemistry Techniques, Analytical; Cholesterol; Coronary Disease; Epidemiology; Geriatrics; Humans; Hypercholesterolemia; Lipids; Lipoproteins; Lipoproteins, LDL; Sex; Spectrophotometry

Topics: Aging; Arteriosclerosis; Autoimmune Diseases; Enzymes; Heart; Humans; Hypertension; Myocardium; Physiology; Sex

Topics: Adolescent; Arteriosclerosis; Body Weight; Cholesterol; Coronary Disease; Epidemiology; Ethnology; Geriatrics; New York; Sex

Topics: Aortic Diseases; Arteriosclerosis; Atherosclerosis; Autopsy; Black People; Humans; Intracranial Arteriosclerosis; Sex; South Africa; Statistics as Topic; White People

Topics: Adolescent; Aorta; Arteriosclerosis; Biomedical Research; Coronary Vessels; Enzymes; Glucosephosphate Dehydrogenase; Histocytochemistry; Isocitrate Dehydrogenase; Lyases; NADP; Oxidoreductases; Pulmonary Artery; Sex

Topics: Arteriosclerosis; Atherosclerosis; Autopsy; Coronary Artery Disease; Coronary Disease; Death, Sudden; Death, Sudden, Cardiac; Humans; Poland; Sclerosis; Sex; Statistics as Topic

Topics: Aging; Animals; Aorta; Arteriosclerosis; Blood Pressure; Blood Pressure Determination; Desoxycorticosterone; Fatty Acids; Hypertension; Hypertension, Renal; Kidney; Lipoprotein Lipase; Nephrectomy; Nitrogen; Protamines; Rabbits; Rats; Research; Sex; Water

Topics: Adolescent; Aorta; Arteriosclerosis; Atherosclerosis; Autopsy; Brachiocephalic Trunk; Carotid Arteries; Child; Coronary Vessels; Epidemiology; Geriatrics; Humans; Iliac Artery; India; Myocardium; Pathology; Sex; Statistics as Topic

Topics: Aging; Arteriosclerosis; Humans; Intracranial Arteriosclerosis; Mental Disorders; Neurologic Manifestations; Physiology; Sex

Topics: Arrhythmias, Cardiac; Arteriosclerosis; Atrial Fibrillation; Atrial Flutter; Cardiac Complexes, Premature; Cardiomegaly; Coronary Disease; Geriatrics; Heart Block; Heart Diseases; Heart Failure; Hypertension; Myocardial Infarction; Obesity; Sex; Statistics as Topic

Topics: Absorption; Achlorhydria; Aging; Arteriosclerosis; Blood Chemical Analysis; Cholesterol; Coronary Disease; Dietary Fats; Fats, Unsaturated; Geriatrics; Humans; Lipids; Obesity; Physical Exertion; Sex; Stress, Physiological

Topics: Aged; Arteriosclerosis; Bundle-Branch Block; Calcinosis; Cardiac Conduction System Disease; Coronary Disease; Electrocardiography; Geriatrics; Heart; Heart Block; Humans; Mitral Valve; Mitral Valve Insufficiency; Mitral Valve Stenosis; Pathology; Radiography, Thoracic; Rheumatic Heart Disease; Sex

Viscosity of whole blood and plasma was measured in 258 apparently healthy subjects of both sexes from 5 to 60 years of age, and in 86 patients with unequivocal evidence of chronic coronary heart disease. Children and young healthy females had the lowest viscosity readings. Healthy young and middle-aged males had significantly higher blood viscosity than females. Patients with coronary heart disease had significantly higher blood viscosity values than healthy groups of the same sex. It is suggested that the higher viscosity of whole blood and of plasma is a contributory factor in development of clinical manifestations of coronary heart disease and possibly of the basic vascular lesion itself.

Topics: Adolescent; Aging; Arteriosclerosis; Blood Viscosity; Child; Coitus; Coronary Artery Disease; Coronary Disease; Female; Geriatrics; Healthy Volunteers; Humans; Infant; Male; Middle Aged; Plasma; Sex; Statistics as Topic

Topics: Adolescent; Aging; Arteriosclerosis; Biomedical Research; Cholesterol; Coronary Disease; Geriatrics; Hungary; Hypercholesterolemia; Hyperlipidemias; Lipid Metabolism; Lipids; Serum; Sex; Statistics as Topic

Topics: Arteriosclerosis; Blood; Catecholamines; Chemistry Techniques, Analytical; Epinephrine; Humans; Hypertension; Hypertension, Renal; Kidney; Norepinephrine; Sex

Topics: Animals; Arteriosclerosis; Central Nervous System; Cholesterol; Haplorhini; Lipid Metabolism; Nervous System; Research; Sex; Sex Characteristics; Stress, Physiological

Topics: Aortic Diseases; Arteriosclerosis; Atherosclerosis; Black People; Coronary Disease; Humans; Louisiana; New Orleans; Pathology; Sex; White People

Topics: Adolescent; Aging; Angiography; Aorta; Aorta, Abdominal; Aortic Diseases; Arteriosclerosis; Blood Circulation; Blood Vessels; Child; Geriatrics; Humans; Infant; Radiography; Sex

Topics: Adolescent; Aging; Arteriosclerosis; Chile; Cholesterol; Diet; Fetal Development; Humans; Mass Screening; Sex

Topics: Adult; Aging; Arteriosclerosis; Chile; Cholesterol; Diet; Dietary Fats; Epidemiology; Humans; Sex; Statistics as Topic

Topics: Adolescent; Aging; Arteriosclerosis; Chile; Cholesterol; Diet; Dietary Fats; Humans; Infant; Infant, Newborn; Sex

Topics: Arteriosclerosis; Female; Humans; Male; Sex

Topics: Arteriosclerosis; Collagen; Connective Tissue; Diet, Atherogenic; Humans; Lung; Sex; Skin; Tendons

Topics: Age Factors; Aging; Arteriosclerosis; Cholesterol; Humans; Male; Sex

Topics: Arteriosclerosis; Blood Pressure; Blood Pressure Determination; Cardio-Renal Syndrome; Crime; Criminals; Heart; Humans; Hypertension; Prisoners; Sclerosis; Sex