sodium-ethylxanthate and Acute-Disease

Topics: Acute Disease; Adolescent; Child, Preschool; Drug Eruptions; Exanthema; Female; Follow-Up Studies; Humans; Incidence; Infant; Male; Risk Factors; Sampling Studies; Severity of Illness Index; Sex; Skin Diseases, Vesiculobullous

Data on bone mineral density (BMD) in acromegaly are conflicting as most previous studies collectively evaluated eugonadal and hypogonadal patients of both sexes, with or without active disease. We have evaluated BMD in 152 acromegalic patients of both sexes with varying disease activity and gonadal status.. Cross-sectional, retrospective.. We studied 152 acromegalic patients (99 women aged 26-72 years, and 53 men aged 21-75 years), 107 with active and 45 with controlled disease. Eighty-five patients had normal gonadal status and 67 were hypogonadal.. In all patients we measured serum GH levels by immunoenzimometric assay, and serum IGF-I levels by radioimmunoassay. BMD was assessed at spine L2-L4 (LS) and at femoral neck (FN) by dual energy X-ray absorptiometry; results are expressed as Z-values.. We evaluated the effect of GH excess on bone at different sites in relation to gonadal status, disease activity and gender. At LS, in respect to the reference population, BMD (mean +/- SE) values were higher in eugonadal patients (active: 0.71 +/- 0.29, P < 0.02; controlled: 0.65 +/- 0.28, P < 0.05) and lower in hypogonadal ones (active: -0.64 +/- 0.35, 0.1 < P < 0.05; controlled: -1.05 +/- 0.36, P < 0.01), regardless of disease activity. On the contrary, at FN, BMD was higher than in the reference population, both in eugonadal (1.01 +/- 0.22, P < 0.001) and hypogonadal (0.63 +/- 0.17, P < 0.001) patients only in subjects with active disease, but not in those in which the disease was controlled (eugonadal: 0.31 +/- 0.23, P = ns; hypogonadal 0.04 +/- 0.28, P = ns). We did not observe any difference in BMD values according to gender both at LS (males vs. females -0.02 +/- 0.30 vs. 0.01 +/- 0.24, P = ns) or at FN (0.77 +/- 0.19 vs. 0.63 +/- 0.15, P = ns).. The anabolic effect of GH excess on bone in acromegalic patients is: (i) gender-independent; (ii) evident at the spine only in eugonadal regardless of disease activity; (iii) evident at femoral neck only in the presence of active disease regardless of gonadal status.

Topics: Absorptiometry, Photon; Acromegaly; Acute Disease; Adult; Aged; Bone Density; Cross-Sectional Studies; Female; Femur Neck; Growth Hormone; Humans; Hypogonadism; Insulin-Like Growth Factor I; Male; Middle Aged; Retrospective Studies; Sex; Spine

Although the sex of an individual confers one of the greatest of the known risks for contracting leukaemia and lymphomas, very little attention is paid to these risks. It is the purpose of this paper to stimulate further research in this area. The sex rate ratios are presented for the commoner haematological malignancies. The male excess in the lymphoid cancers is most marked in the youngest age group in non-Hodgkin's lymphoma and Hodgkin's disease, while acute lymphoblastic leukaemia shows equal sex ratios in the childhood peak. Both chronic lymphocytic leukaemia and lymphocytic lymphoma display an unusual pattern, hitherto undescribed, with a large male excess specific to the 40s and 60s age groups. The myeloid sex ratios are all characterized by slight female excess in early adulthood followed by marked male excess. The reasons for these patterns are discussed.

Topics: Acute Disease; Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Child; Child, Preschool; Female; Hematologic Neoplasms; Hodgkin Disease; Humans; Incidence; Infant; Infant, Newborn; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid; Lymphoma, Non-Hodgkin; Male; Middle Aged; Multiple Myeloma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk; Sex; Sex Distribution

For a rather long period of time the authors have seen and followed up the evolution of a very characteristic syndrome. It is not frequent and it appears only in puberty, in boys as well as in girls, and it has been called "acute obsessive crisis". It appears suddenly in the form of a very intense anguish with the constant repetition of questions about the possibility of being in mortal sin and with the evidence of poorness of thought. The acute period lasts about 72 hours and then remission begins spontaneously and in one week it is all over. The evolution of this syndrome showed that it is not repeated later and that it does not leave any defect. It is essential to make the differential diagnosis with schizophrenia. The author's hypothesis is that acute obsessive crisis is the extreme manifestation of the painful mental experiences associated to corporal changes so frequent during puberty.

Topics: Acute Disease; Adolescent; Catholicism; Child; Female; Guilt; Humans; Male; Obsessive-Compulsive Disorder; Puberty; Sex; Syndrome; Thinking

The mortality from acute myocardial infarction has remained unchanged over the past three decades. The records of 200 patients hospitalized because of acute myocardial infarction were analyzed at St. Paul's Hospital, Vancouver. Criteria for diagnosis were autopsy evidence and electrocardiographic evidence of acute muscle necrosis. Sixty-two patients died, 30 in the first three days and 41 in the first week; 33 of these deaths were due to cardiac arrhythmias, cardiac arrest or hypotension. Anticoagulants improved the mortality, but the degree of control was not a factor. Thromboembolism was significantly decreased by anticoagulants. Forty-nine patients died in shock; pressor amines did not improve the mortality in such cases. This study emphasizes the need for intensive care during the early critical period of the illness. Prompt adequate therapy of shock may improve the prognosis.

Topics: Acute Disease; Aging; Anterior Wall Myocardial Infarction; Anticoagulants; Arrhythmias, Cardiac; Critical Care; Diagnosis; Drug Therapy; Electrocardiography; Geriatrics; Heart Arrest; Humans; Hypotension; Intensive Care Units; Mortality; Myocardial Infarction; Sex; Shock; Statistics as Topic; Sympathomimetics; Thromboembolism

The clinical picture of regional enteritis was reviewed in 98 cases collected from five hospitals in the City of Edmonton. There was no apparent racial prevalence, although only one case was reported among Indians and Eskimos. More than one-half had their onset between the ages of 11 and 30 years. Men were more commonly affected than women. The onset in 44 patients was acute and closely mimicked acute appendicitis. Twenty-eight patients had had abdominal surgery prior to the onset of symptoms. Major symptoms were abdominal pain, diarrhea and weight loss. Abdominal tenderness, fever and abdominal mass were the most consistent physical signs. The most valuable diagnostic procedure was radiological examination of the bowel. Complications were largely confined to the gastrointestinal tract. In the majority of cases, surgery was the ultimate form of therapy.

Topics: Abdominal Pain; Acute Disease; Adolescent; Appendectomy; Appendicitis; Canada; Child; Crohn Disease; Diagnosis; Diarrhea; Enteritis; Epidemiology; Female; Gastroenterostomy; Gastrointestinal Hemorrhage; Genetics, Medical; Geriatrics; Hemorrhage; Humans; Intestinal Perforation; Male; Sex; Surgical Procedures, Operative

Topics: Acute Disease; Appendicitis; Child; Humans; Morbidity; Seasons; Sex

Topics: Acute Disease; Humans; Myocardial Infarction; Sex; Sex Characteristics

A study has been made of the influence of age and sex on the incidence of cases of appendicitis and of fatal appendicitis in children and young adults. Appendicitis is uncommon in children under the age of 5, but the proportion of cases complicated by peritonitis is large, and the death rate in the population of this age is relatively high. Appendicitis is very common in adolescents, but here the proportion of cases complicated by peritonitis is small. However, because of the frequency of the condition, the death rate in the general population of this age is high, with a maximum at about the age of 15 years. These findings are compatible with the suggestion that the appendix during the 'teens is particularly liable to obstruct and hence to become inflamed because of the large proportion of lymphoid tissue which it contains. Inflammation of the appendix is more common in males than in females, and this male excess is greater in infants and pre-school children than it is in children of school age.

Topics: Acute Disease; Adolescent; Adult; Appendicitis; Child; Female; Humans; Incidence; Infant; Male; Sex