sodium-dodecyl-sulfate and Stomach-Ulcer

Topics: Anti-Ulcer Agents; Drug Hypersensitivity; Excipients; Female; Humans; Hypersensitivity, Delayed; Middle Aged; Omeprazole; Sodium Dodecyl Sulfate; Stomach Ulcer

Reflux of duodenal contents into the stomach has been implicated in the disruption of mucosal defence and the subsequent occurrence of gastric ulcer. The change produced in the rheological properties following the addition of bile salts and phospholipids to mucus samples was used to assess resultant structural changes. Sodium deoxycholate, sodium taurodeoxycholate, sodium glycocholate, and lysophosphatidylcholine decreased both viscosity and elasticity, indicating that structural breakdown had occurred, whereas phosphatidylcholine could not be shown to have any effect. It is therefore suggested that some of the ulcerogenic activity of naturally occurring surfactants may be associated with their ability directly to reduce mucus consistency.

Topics: Bile Acids and Salts; Compliance; Deoxycholic Acid; Glycocholic Acid; Humans; Mucus; Phosphatidylcholines; Sodium Dodecyl Sulfate; Stomach Ulcer; Taurodeoxycholic Acid; Viscosity

The role of bile salts and refluxed duodenal content in the pathogenesis of acute gastric ulcers in the shocked rat were examined. The addition of cholestyramine to duodenal contents inhibits their ulcerogenic action in the stomach of rats challenged by an acid load, (100 mEq/l Hcl) and subsequently bled to a mean blood pressure of 20 mm Hg. Also, bile duct ligation 2 days before the reflux procedure and subsequent shock also inhibited ulcer formation. An ex vivo rat gastric chamber was used to further demonstrate that the "barrier" breaking action of bovine sodium taurocholate and sodium lauryl sulphate could be prevented by cholestyramine. Cholestyramine also inhibited the usual rapid depression of the transmucosal potential difference (PD) produced by both of these agents. It is concluded that cholestyramine protects the gastric mucosa from ulceration by blocking the barrier breaking action of bile salts in duodenal chyme.

Topics: Bile Acids and Salts; Bile Ducts; Carbon; Cholestyramine Resin; Colloids; Duodenum; Female; Gastric Mucosa; Humans; Hydrogen-Ion Concentration; Ligation; Male; Placebos; Potentiometry; Shock, Hemorrhagic; Sodium Dodecyl Sulfate; Stomach Ulcer; Taurocholic Acid