sodium-dodecyl-sulfate and Skin-Neoplasms

sodium-dodecyl-sulfate has been researched along with Skin-Neoplasms* in 7 studies

Other Studies

7 other study(ies) available for sodium-dodecyl-sulfate and Skin-Neoplasms

ArticleYear
Molecular subtyping of Borrelia burgdorferi sensu lato isolates from five patients with solitary lymphocytoma.
    The Journal of investigative dermatology, 1997, Volume: 108, Issue:1

    Solitary lymphocytoma is a rare cutaneous manifestation of Lyme borreliosis that has been reported almost exclusively from Europe. This suggests that its etiologic agent may be absent or extremely rare on the North American continent. All three species of B. burgdorferi sensu lato known to be associated with human Lyme borreliosis (B. burgdorferi sensu stricto, B. garinii, and B. afzelii have been isolated in Europe, whereas only B. burgdorferi sensu stricto has been found in North America. This suggests that either B. garinii or B. afzelii might be the etiologic agent of borrelial lymphocytoma. To investigate this hypothesis we characterized five strains of B. burgdorferi sensu lato isolated from lymphocytoma lesions of patients residing in Slovenia. The methods used included: large restriction fragment pattern analysis of restriction enzyme MluI-digested genomic DNA, plasmid profiling, protein profiling, ribotyping using 5S, 16S, and 23S rDNA probes, and polymerase chain reaction amplification of the rrf (5S)-rrl (23S) intergenic spacer region. Molecular subtyping showed that four of the five isolates belonged to the species B. afzelii; however, this species is the predominant patient isolate in Slovenia and, therefore, may not represent a preferential association with lymphocytoma. The fifth isolate appeared to be most closely related to the DN127 genomic group of organisms. Further characterization of the isolate revealed that it possessed a unique molecular "fingerprint." The results not only show that borrelial lymphocytoma can be caused by B. afzelii but also demonstrate an association with another genomic group of B. burgdorferi sensu lato that is present in North America as well.

    Topics: Adult; Aged; Antigens, Surface; Bacterial Outer Membrane Proteins; Bacterial Vaccines; Biopsy; Borrelia burgdorferi Group; DNA Primers; DNA, Bacterial; Electrophoresis, Gel, Pulsed-Field; Electrophoresis, Polyacrylamide Gel; Europe; Female; Gene Amplification; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lipoproteins; Lyme Disease; Middle Aged; Polymerase Chain Reaction; Restriction Mapping; Skin; Skin Neoplasms; Sodium Dodecyl Sulfate

1997
Decreased number and function of antigen-presenting cells in the skin following application of irritant agents: relevance for skin cancer?
    The Journal of investigative dermatology, 1989, Volume: 92, Issue:6

    The mechanism of irritant dermatitis and the immunologic consequences of such reactions are unclear. We evaluated the number and function of epidermal antigen-presenting cells contained in epidermal cell suspensions obtained from normal and irritant patch test reaction sites. Application of sodium lauryl sulfate or croton oil to human skin in vivo resulted in a progressive depletion in the number of epidermal OKT6+HLA-DR+ (T6+DR+) Langerhans cells (LC) from 3.1 +/- 0.2% of total epidermal cells (EC) to 1.2 +/- 0.1% after 8 d (mean values +/- SEM, N = 9). Between 1-4 d irritant patch test sites demonstrated an influx of non-Langerhans cell T6-DR+ cells. These cells were not DR+ keratinocytes but appeared to be of bone marrow derivation because they expressed the marker, HLe1. Among bone marrow derived cells, the T6-DR+EC appeared to be of monocyte, macrophage lineage, because they expressed the determinant recognized by the OKM5 (M5) antibody. Despite the induction of M5+DR+EC the total number of DR+EC showed progressively decreasing percentages over an 8-d period. Partial recovery to 73 +/- 12% of control value was observed at 2 weeks, with full recovery by 4 weeks after challenge. Concomitantly with the depletion of DR+EC, the capacity of EC to present alloantigens to T cells decreased. This reduction in antigen-presenting cell activity was strongly correlated to the reduction in total DR+ EC (r = 0.94, p less than 0.05). Thus, the capacity of irritants such as croton oil to abrogate the function of epidermal antigen-presenting cells may be related to the tumor promoting potential of these agents.

    Topics: Administration, Cutaneous; Adult; Aged; Antigen-Presenting Cells; Croton Oil; Epidermis; HLA-DR Antigens; Humans; Irritants; Langerhans Cells; Leukocytes; Middle Aged; Skin; Skin Neoplasms; Sodium Dodecyl Sulfate; T-Lymphocytes; Time Factors

1989
[Chromatography of membrane proteins in sodium dodecyl sulfate. II) Membrane proteins of some human cutaneous tumors].
    Bollettino della Societa italiana di biologia sperimentale, 1981, Oct-30, Volume: 57, Issue:20

    Topics: Angiomatosis; Chemical Phenomena; Chemistry; Electrophoresis, Polyacrylamide Gel; Histiocytoma, Benign Fibrous; Humans; Intracellular Membranes; Melanoma; Membrane Proteins; Osteitis Fibrosa Cystica; Skin Neoplasms; Sodium Dodecyl Sulfate

1981
[Chromatography of membrane proteins in sodium dodecyl sulfate. I) Methods].
    Bollettino della Societa italiana di biologia sperimentale, 1981, Oct-30, Volume: 57, Issue:20

    The purpose of this study is to classify the membrane proteins from some cutaneous tumours (basal cell epitheliomas, squamous epitheliomas, melanomas) and possibly detect the ones which are characteristic of each type of tumour. The microsomal, mitochondrial and nuclear fractions were purified following the usual techniques. The membrane proteins were solubilized with sodium dodecyl sulfate, treated with iodoacetamide and chromatographed in SDS-acrylamide slab-gel.

    Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Chemical Phenomena; Chemistry; Electrophoresis, Polyacrylamide Gel; Humans; Intracellular Membranes; Melanoma; Membrane Proteins; Skin Neoplasms; Sodium Dodecyl Sulfate

1981
Membrane proteins in human skin tumors.
    Archives of dermatological research, 1981, Volume: 271, Issue:4

    The microsomal, mitochondrial, and nuclear fractions of cutaneous tumors have been investigated. Cutaneous tumors were homogenized and microsomal, mitochondrial, and nuclear fractions were purified. The membrane proteins were solubilized with sodium duodecyl sulfate (SDS). The membrane lipids were removed and membrane proteins were solubilized again in a small volume of SDS solution and chromatographed in SDS-acrylamide slab-gel. The plates were stained with Coomassie Brilliant Blue to show protein bands. The preliminary results show that the electrophoretic profiles of microsomal proteins are characteristic of some tumors.

    Topics: Carcinoma; Carcinoma, Squamous Cell; Chromatography, Gel; Fibroma; Humans; Intracellular Membranes; Melanoma; Membrane Proteins; Microsomes; Mitochondria; Neoplasm Proteins; Nuclear Envelope; Skin Neoplasms; Sodium Dodecyl Sulfate

1981
The innervation of hyperplastic epidermis in the mouse: a light microscopic study.
    The Journal of investigative dermatology, 1975, Volume: 64, Issue:3

    The innervation of the skin of hairless mice has been studied following induction of epidermal hyperplasia by physical and chemical methods. Physical stimuli comprised ultraviolet irradiation, heat, wounding, and friction. Effective chemicals included benzene, carbon tetrachloride, chloroform, creosote, formaldehyde, hexadecane, hydrobromic acid, sodium lauryl sulfate, and turpentine. Epidermal hyperplasia, however produced, was associated with growth of sensory nerve fibers into the outer part of the epidermis. Following a single 10-min exposure to an ultraviolet sunalmp at 40 cm, the nerves extended into the epidermis within 24 hr and disappeared during the second week as the epidermis reverted to its normal thickness. Repeated irradiation (until tumors appeared) was accompanied by persistent hyperplasia and neural invasion. Of 32 papillomas examined, intraepithelial nerves were found in 28. The presence and location of nerves in the tumor epithelium were related to the incorporation of tactile hair disc epithelium. The hyperplastic regenerative epithelium at the margins of skin ulcers were also invaded by nerves which sometimes followed the migrating epithelium across the ulcer floor. Since the regenerative epithelium was not directly treated, it was concluded that the proliferation of nervous tissue in response to skin injury was the result of the hyperplasia per se, regardless of the method used to produce it.

    Topics: Acids; Alkanes; Animals; Benzene; Bromides; Carbon Tetrachloride; Chloroform; Creosote; Formaldehyde; Hot Temperature; Hyperplasia; Mice; Nerve Endings; Nerve Regeneration; Papilloma; Skin; Skin Diseases; Skin Neoplasms; Skin Ulcer; Sodium Dodecyl Sulfate; Turpentine; Ultraviolet Rays

1975
Proteins from melanosomes of mouse and chick pigment cells.
    Journal of cellular physiology, 1973, Volume: 82, Issue:1

    Topics: Animals; Cell Fractionation; Chick Embryo; Chromatophores; Electrophoresis, Polyacrylamide Gel; Hair; Melanoma; Mice; Molecular Weight; Organoids; Proteins; Retinal Pigments; Skin Neoplasms; Sodium Dodecyl Sulfate

1973
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