sodium-dodecyl-sulfate and Renal-Insufficiency--Chronic

Estrogenic hormones, found as micropollutants in water systems, give rise to grave concerns for human health and marine ecosystems, triggering a cascade of adverse effects. This research presents an innovative manufacturing approach using nanoscale layered double hydroxides of magnesium and iron, with sodium dodecyl sulfate surfactant, to create highly efficient sorbent cement kiln dust (CKD) based beads (CKD/MgFe-SDS-LDH-beads). These beads effectively remove estrone from water. Optimization of the preparation process considered factors like molar Mg/Fe ratio, CKD dosage, pH, and SDS dosage using Response Surface Methodology (RSM). The adsorption process was well-characterized by Langmuir isotherm and pseudo-second-order kinetic models, demonstrating a remarkable 6.491 mg/g sorption capacity. Results proved that the calcite was the main component of the CKD with miners of dolomite, and quartz. Adsorption capacity, surface charges, and the availability of vacant sites may be the main mechanisms responsible of removal process. Experimental tests confirmed the beads' potential for estrone removal, aligning with the Bohart-Adams and Thomas-BDST models. This study introduces a promising, eco-friendly solution for addressing water contamination challenges.

Topics: Adsorption; Ecosystem; Estrogens; Estrone; Humans; Hydroxides; Kinetics; Nanoparticles; Renal Insufficiency, Chronic; Sodium Dodecyl Sulfate; Water; Water Pollutants, Chemical

Renal regeneration approaches offer great potential for the treatment of chronic kidney disease, but their availability remains limited by the clinical challenges they pose. In the present study, we used continuous detergent perfusion to generate decellularized (DC) rat kidney scaffolds. The scaffolds retained intact vascular trees and overall architecture, along with significant concentrations of various cytokines, but lost all cellular components. To evaluate its potential in renal function recovery, DC scaffold tissue was grafted onto partially nephrectomized rat kidneys. An increase of renal size was found, and regenerated renal parenchyma cells were observed in the repair area containing the grafted scaffold. In addition, the number of nestin-positive renal progenitor cells was markedly higher in scaffold-grafted kidneys compared to controls. Moreover, radionuclide scan analysis showed significant recovery of renal functions at 6 weeks post-implantation. Our results provide further evidence to show that DC kidney scaffolds could be used to promote renal recovery in the treatment of chronic kidney disease.

Topics: Animals; Cytokines; Enzyme-Linked Immunosorbent Assay; Extracellular Matrix; Kidney; Male; Microscopy, Electron, Transmission; Nephrectomy; Perfusion; Rats; Rats, Sprague-Dawley; Regeneration; Renal Insufficiency, Chronic; Sodium Dodecyl Sulfate; Stem Cells; Surface-Active Agents; Tissue Engineering; Tissue Scaffolds; Tomography, Emission-Computed, Single-Photon