sodium-dodecyl-sulfate and Pruritus
sodium-dodecyl-sulfate has been researched along with Pruritus* in 8 studies
Trials
3 trial(s) available for sodium-dodecyl-sulfate and Pruritus
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A pramoxine-based anti-itch lotion is more effective than a control lotion for the treatment of uremic pruritus in adult hemodialysis patients.
The objective of this study was to evaluate the efficacy of a commercially available anti-itch lotion containing 1% pramoxine hydrochloride versus control lotion in the treatment of uremic pruritus in adult hemodialysis patients.. This was a randomized, double-blind, controlled comparative trial set in a community hemodialysis center. The study population comprised 28 individuals (mean age 53.5) with moderate to severe uremic pruritus who had been receiving hemodialysis for at least 3 months. All participants were recruited from one community hemodialysis center. Topical anti-itch lotion containing 1% pramoxine was applied twice daily to all affected areas of pruritus for 4 weeks. The main outcome measure was a reduction in itch intensity. Secondary outcomes included increases in the investigator's global assessment and improvement in skin hydration.. There was a 61% decrease in itch intensity in the treatment group, whereas a 12% reduction in itch intensity was observed in the control group. The rate of decline in itching was also greater in the treatment arm versus the control arm. No significant differences were displayed in other studied disease-related variables.. Our study shows that individuals using pramoxine 1% lotion experienced a reduction in pruritus to a greater degree than those using the control lotion. This safe, convenient and effective topical lotion may potentially benefit the large number of patients affected by pruritus associated with end-stage renal disease. Topics: Administration, Topical; Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Emollients; Female; Follow-Up Studies; Humans; Kidney Failure, Chronic; Male; Middle Aged; Morpholines; Pain Measurement; Patient Satisfaction; Probability; Propylene Glycols; Pruritus; Reference Values; Renal Dialysis; Sensitivity and Specificity; Severity of Illness Index; Sodium Dodecyl Sulfate; Statistics, Nonparametric; Treatment Outcome; Young Adult | 2009 |
Experimental itch in sodium lauryl sulphate-inflamed and normal skin in humans: a randomized, double-blind, placebo-controlled study of histamine and other inducers of itch.
Investigations of pruritogenic substances in humans have involved intradermal injections in normal skin; itching of inflamed skin has been little studied.. To develop an itch model with provocation of itch in experimentally inflamed skin as well as in normal skin, using subjects as self-controls.. In 32 non-atopic volunteers aged 21-30 years, the skin of five selected test sites on one volar forearm was pretreated for 24 h with large Finn chambers containing 1% sodium lauryl sulphate (SLS) used as a standard contact irritant to induce inflammation. Twenty microlitres of different pruritogenic substances [histamine, substance P, neurokinin A, neurokinin B, trypsin, platelet-activating factor (PAF) and serotonin] and saline as control were injected intradermally into the inflamed test sites and in corresponding non-treated sites on the opposite forearm. The test individuals scored itch intensity on a visual analogue scale for 20 min, and weal area was then measured. :. Histamine and substance P induced itch in both normal and inflamed skin compared with a saline reference. Neurokinin A, trypsin, PAF and serotonin only elicited itch in normal skin, and neurokinin B neither elicited itch in normal skin nor in inflamed skin. Itch was induced in normal and SLS-inflamed skin to a similar magnitude. However, weal area after histamine was significantly (P < 0.001) larger in inflamed skin when compared with normal skin.. Histamine and substance P elicited itch to the same degree in normal skin and inflamed skin pretreated with SLS despite a stronger weal response in inflamed skin. Mediators present in inflamed skin did not potentiate itch, a c-fibre-mediated neuronal response. The weal reaction is based on enhanced vascular permeability (protein extravasation). A greater skin perfusion in inflamed skin may therefore have increased the weal size. We propose an experimental model in humans for testing of itch involving both normal and inflamed skin. The model has the potential for use in evaluating new topical and systemic treatments of itch. Topics: Adult; Dermatitis, Contact; Double-Blind Method; Edema; Erythema; Female; Histamine; Humans; Injections, Intradermal; Male; Neuropeptides; Pain; Pain Measurement; Pruritus; Severity of Illness Index; Sodium Dodecyl Sulfate | 2002 |
Topically applied aspirin decreases histamine-induced wheal and flare reactions in normal and SLS-inflamed skin, but does not decrease itch. A randomized, double-blind and placebo-controlled human study.
Topically applied aspirin has recently been reported to decrease histamine-induced itch in human volunteers. Our aim is to confirm this and to study the antipruritic ability of topical aspirin in inflamed skin. In 24 non-atopic volunteers, an inflammatory skin reaction was induced in forearm skin at 5 different sites by sodium lauryl sulphate contained in Finn Chambers. Aspirin 10%, aspirin 1%, mepyramine 5% and vehicle were applied to the inflamed and corresponding non-inflamed areas 20 min before itch induction with intradermal histamine injection. Itch and pain were scored on a visual analogue scale at regular intervals. Wheal and flare areas were measured. No difference in itch intensities was found after application of aspirin, mepyramine and vehicle, but more itch was induced in aspirin and mepyramine pretreated sites in inflamed skin compared to normal skin (p<0.05). In normal skin, flare areas were smaller after pretreatment with aspirin 10% (p<0.05) and mepyramine (p<0.001), as were wheal areas after mepyramine (p<0.01), compared to vehicle pretreatments. In inflamed skin, flare areas were smaller after pretreatment with aspirin 10% (p<0.01) and mepyramine (p<0.001), as were wheal areas after aspirin 10% (p<0.01), aspirin 1% (p<0.05) and mepyramine (p<0.001). We conclude that despite a significant skin penetration as measured by the influence on wheal and flare reactions, topically applied aspirin did not decrease histamine-induced itch in the model used. Topics: Administration, Topical; Adult; Analysis of Variance; Aspirin; Dermatitis, Irritant; Double-Blind Method; Female; Histamine; Humans; Injections, Intradermal; Male; Pain; Probability; Prospective Studies; Pruritus; Pyrilamine; Reference Values; Sensitivity and Specificity; Severity of Illness Index; Skin Tests; Sodium Dodecyl Sulfate; Treatment Outcome | 2002 |
Other Studies
5 other study(ies) available for sodium-dodecyl-sulfate and Pruritus
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Characterization of cowhage-induced pruritus in inflamed and non-inflamed skin.
Pruritus is a major symptom of many inflammatory diseases and impacts greatly the quality of life in patients. We aimed to specify the characteristics of experimentally induced pruritus in normal skin and in experimentally induced inflammatory dermatitis in healthy volunteers.. Skin inflammation was induced by the repeated application of sodium lauryl sulphate (SLS 2%) on the volar forearms of 30 healthy volunteers. Inflammatory dermatitis intensity was assessed using the eczema score adapted from Frosch and Kligman. Non-histaminergic pruritus was induced by cowhage spicules rubbed on the volar forearms and recorded for 30 min on a 10-cm visual analogue scale (VAS) in both non-inflamed and inflamed skin.. Induction of inflammatory dermatitis by SLS resulted in a mild inflammatory dermatitis with an inflammation score of 2.3 ± 0.1 within 7 days of treatment. Cowhage-induced pruritus was of markedly higher intensity (P < 0.001), and all but two individuals had higher maximum pruritus intensity in inflamed skin as compared to non-inflamed skin, whereas the kinetics of the pruritus response were similar. The quality of cowhage-induced pruritus was significantly different with more 'burning' and 'painful sensations' in inflamed skin (P < 0.01). Maximum pruritus intensity in inflamed skin strongly correlated with maximum pruritus intensity in non-inflamed skin (r = 0.51, P = 0.004). Skin hydration, skin barrier integrity and dermatitis severity did not correlate with pruritus intensity.. Taken together, pruritus in inflamed skin is perceived as more intense, painful and burning. This may explain, in part, why pruritus is a major driver of quality-of-life impairment in patients with chronic inflammatory skin conditions such as atopic dermatitis. Topics: Adolescent; Adult; Dermatitis; Female; Humans; Male; Middle Aged; Mucuna; Pruritus; Risk Factors; Severity of Illness Index; Sodium Dodecyl Sulfate; Symptom Assessment; Young Adult | 2020 |
Pretreatment with substance P alleviates irritation due to sodium lauryl sulphate exposure by maintaining E-cadherin expression on human keratinocytes.
Topics: Cadherins; Cell Adhesion; Cell Survival; Dermatitis, Irritant; Detergents; Humans; Keratinocytes; Neurotransmitter Agents; Pruritus; Sodium Dodecyl Sulfate; Substance P | 2018 |
Surfactant-induced chronic pruritus: Role of L-histidine decarboxylase expression and histamine production in epidermis.
Shampoo and cleansers containing anionic surfactants including sodium dodecyl sulphate (SDS) often cause pruritus in humans. Daily application of 1-10% SDS for 4 days induced hind-paw scratching (an itch-related behaviour) in a concentration-dependent manner, and 10% SDS also caused dermatitis, skin dryness, barrier disruption, and an increase in skin surface pH in mice. SDS-induced scratching was inhibited by the opioid receptor antagonist naloxone and the H histamine receptor antagonist terfenadine. Mast-cell deficiency did not inhibit SDS-induced scratching, although it almost completely depleted histamine in the dermis. Treatment with SDS increased the histamine content of the epidermis, but not that of the dermis. SDS treatment increased the gene expression and post-translation processing of L-histidine decarboxylase in the epidermis. The present results suggest that repeated application of SDS induces itch through increased production of epidermal histamine, which results from an increase in the gene expression and post-translation processing of L-histidine decarboxylase. Topics: Animals; Behavior, Animal; Disease Models, Animal; Enzyme Induction; Epidermis; Histamine; Histamine H1 Antagonists; Histidine Decarboxylase; Male; Mast Cells; Mice, Inbred ICR; Narcotic Antagonists; Protein Processing, Post-Translational; Pruritus; Sarcosine; Signal Transduction; Sodium Dodecyl Sulfate; Surface-Active Agents; Time Factors; Up-Regulation | 2014 |
Beer anaphylaxis.
Topics: Adult; Anaphylaxis; Angioedema; Beer; Double-Blind Method; Electrophoresis, Polyacrylamide Gel; Female; Food Hypersensitivity; Humans; Male; Placebos; Pruritus; Sodium Dodecyl Sulfate | 1999 |
Frequency of bullous pemphigoid-like antibodies as detected by western immunoblot analysis in pruritic dermatoses.
Ninety-seven patients suffering from a pruritic dermatosis were screened for the detection of bullous pemphigoid (BP) antibodies (ab) using the Western immunoblot (WB) analysis technique.. Twenty-four patients (25%) reacted at least twice with the BP antigen on WB analysis at a 1/10 dilution: seven had typical BP, four had papular BP, 10 had pruritus and prurigo of unknown origin, two had eczema, and one had lichen planus. This corresponds to 13% of BP-type ab in patients who did not fulfill criteria for BP. Therefore, we did the following: (1) tested a control group of 24 subjects; (2) assessed the reproducibility of the WB method by retesting the same serum samples on different epidermal extracts; and (3) estimated the BP ab titer. None of the 24 control subjects had detectable BP ab, and reproducible results were obtained in all groups when serum samples were retested at the 1/10 dilution. Although 86% (6/7) of patients with BP had BP ab titers of 1/100 or greater, only 60% (6/10) of the group with pruritus and prurigo and 33% (1/3) of the group with eczema reached such titers.. These results indicate that due to its sensitivity, the WB method can detect low titers of BP ab in patients with pruritic dermatoses who did not fulfill criteria for BP, and therefore we question the specificity of this method. Topics: Adult; Aged; Aged, 80 and over; Antibodies; Blotting, Western; Eczema; Electrophoresis, Polyacrylamide Gel; Epitopes; Female; Fluorescent Antibody Technique; Follow-Up Studies; Humans; Keratinocytes; Lichen Planus; Male; Middle Aged; Pemphigoid, Bullous; Prurigo; Pruritus; Reproducibility of Results; Skin; Sodium Dodecyl Sulfate | 1992 |