sodium-dodecyl-sulfate and Intestinal-Diseases

A healthy intestinal barrier prevents uptake of allergens and toxins, whereas intestinal permeability increases following chemotherapy and in many gastrointestinal and systemic diseases and disorders. Currently, there are no approved drugs that target and repair the intestinal epithelial barrier while there is a medical need for such treatment in gastrointestinal and related conditions. The objective of this single-pass intestinal perfusion study in rats was to investigate the preventive cytoprotective effect of three mucosal protective drugs-melatonin, misoprostol, and teduglutide-with different mechanisms of action on an acute jejunal injury induced by exposing the intestine for 15 min to the anionic surfactant, sodium dodecyl sulfate (SDS). The effect was evaluated by monitoring intestinal clearance of

Topics: Animals; Drug Combinations; Edetic Acid; Intestinal Diseases; Intestinal Mucosa; Intestines; Male; Melatonin; Misoprostol; Perfusion; Permeability; Phenobarbital; Rats; Rats, Wistar; Sodium Dodecyl Sulfate