sodium-dodecyl-sulfate and Hepatoblastoma

We developed Cur nanosuspension (Cur-NS) with PVPK30 and SDS as stabilizers to improve poor water solubility and short biological half-time of Cur.. Physicochemical characterization of Cur-NS was characterized systematically. The in-vitro dissolution, cytotoxicity and in-vivo pharmacokinetic experiments of Cur-NS were also evaluated.. Scanning electron microscope indicated that the morphologies of Cur-NS were spherical or ellipsoidal in shape. X-ray diffraction verified that Cur was successfully developed as nanoparticles with an amorphous phase in Cur-NS. Fourier transform infrared spectroscopy suggested there was no degradation about Cur in the Cur-NS. Furthermore, the in-vitro study showed that the cumulative release of the Cur-NS was 82.16 ± 2.62% within 34 h and the cytotoxicity of the Cur-NS against HepG2 cells was much better than raw Cur. Besides, in-vivo pharmacokinetics in rats by intravenous injection displayed that the in-vivo process of Cur-NS pertained to two-compartment model. Meanwhile, the t1/2 and AUC0-t of Cur-NS were enhanced by 11.0-fold and 4.2-fold comparing to Cur solution.. The Cur-NS significantly increased the water solubility and half-time of Cur, suggesting its potential as a nanocarrier in the delivery of Cur for future clinical application.

Topics: Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Biological Availability; Curcuma; Curcumin; Drug Delivery Systems; Female; Hep G2 Cells; Hepatoblastoma; Humans; Liver Neoplasms; Male; Nanoparticles; Particle Size; Pharmaceutical Solutions; Polyvinyls; Rats, Sprague-Dawley; Sodium Dodecyl Sulfate; Solubility; Spectroscopy, Fourier Transform Infrared; Water; X-Ray Diffraction