sodium-dodecyl-sulfate and Facial-Pain

To compare the effects of sodium lauryl sulfate (SLS)-free and SLS-containing dentifrice in patient with recurrent aphthous stomatitis (RAS).. The design of this study was a double-blind crossover trial. The 90 subjects were divided into three groups: group I used SLS-free (a commercially available SLS-free dentifrice) and SLS-A (SLS-free + 1.5% SLS), group II used SLS-A and SLS-B (a commercially available 1.5% SLS-containing dentifrice), and group III used SLS-free and SLS-B. The subjects used one of the two assigned dentifrices for 8 weeks and then the other for the following 8 weeks. The order of the dentifrices used was selected at random, and there was a 2-week washout period between the two phases. The clinical parameters (number of ulcers, number of episodes, duration of ulcers, mean pain score) were compared between the two phases for each group.. The number of ulcers and episodes did not differ significantly between SLS-A, SLS-B, and SLS-free. Only duration of ulcers and mean pain score was significantly decreased during the period using SLS-free.. Although SLS-free did not reduce the number of ulcers and episodes, it affected the ulcer-healing process and reduces pain in daily lives in patients with RAS.

Topics: Adult; Cross-Over Studies; Dentifrices; Double-Blind Method; Facial Pain; Female; Humans; Male; Middle Aged; Sodium Dodecyl Sulfate; Statistics, Nonparametric; Stomatitis, Aphthous; Surface-Active Agents; Toothbrushing

Previous reports have indicated that certain mouthrinses, even when used as directed can induce oral pain. In order to help determine the causal agent(s), various commercially available mouthrinses, as well as control solutions, were tested in a psychophysical study in which subjects rated categories of pain during and after mouthrinsing. More specifically, the studies tested the effects of ethanol concentration on induced pain. The results show that there is a direct relationship between ethanol content and the amount of induced pain. Furthermore, the amount of pain was found to increase with time of rinsing, and to slowly decrease after cessation of rinsing. Lastly, comparison of ethanol/water controls with a marketed product (Clear Choice) matched for ethanol content showed that, while ethanol was the key factor in mouthwash-induced oral pain, other presently unidentified agents can also add to the effect.

Topics: Adult; Alkaloids; Analysis of Variance; Benzoates; Benzophenanthridines; Cetylpyridinium; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Ethanol; Facial Pain; Female; Humans; Isoquinolines; Male; Middle Aged; Mouthwashes; Organic Chemicals; Pain Measurement; Quaternary Ammonium Compounds; Regression Analysis; Salicylates; Sodium Dodecyl Sulfate; Terpenes; Time Factors