sodium-dodecyl-sulfate and Drug-Hypersensitivity

Topics: Anthralin; Croton Oil; Dermatitis; Drug Hypersensitivity; Humans; Inflammation; Skin Diseases; Skin Tests; Sodium Dodecyl Sulfate

Topics: Anti-Ulcer Agents; Drug Hypersensitivity; Excipients; Female; Humans; Hypersensitivity, Delayed; Middle Aged; Omeprazole; Sodium Dodecyl Sulfate; Stomach Ulcer

Skin hyperirritability to irritants as well as atopy are considered to be predisposing factors for contact dermatitis. The aim of the study was to evaluate whether these predictive factors are independent or whether they are so closely related that one could possibly replace the other 205 metalworker trainees underwent skin examination for skin atopy, including standardized questionnaire, clinical examination of the skin and a series of skin irritability tests. These tests included measurements of transepidermal water loss (TEWL) before and after irritation with 3 different irritants: sodium lauryl sulfate (SLS), dimethylsulfoxide (DMSO) and sodium hydroxide (NaOH). The results of the linear regression analysis demonstrate that skin atopy is not associated with increased skin irritability, as assessed by the irritability testing methods presented.

Topics: Adolescent; Adult; Dermatitis, Atopic; Dermatitis, Contact; Dermatitis, Irritant; Dermatitis, Occupational; Dimethyl Sulfoxide; Drug Hypersensitivity; Evaluation Studies as Topic; Humans; Male; Metallurgy; Multivariate Analysis; Regression Analysis; Skin Tests; Sodium Dodecyl Sulfate; Sodium Hydroxide; Switzerland; Water Loss, Insensible

Allergy to latex-containing articles is becoming more and more important because it can result in unexpected life-threatening anaphylactic reactions in sensitized individuals.. A protein of 58 kd with an isoelectric point of 8.45 was purified from raw latex and from latex gloves and identified as the major allergen, completely blocking specific IgE antibodies in the serum of latex-sensitized subjects. The allergen is a noncovalent homotetramer molecule, in which the 14.6 kd monomer was identified, by amino acid composition and sequence homologies of tryptic peptides, to be the rubber elongation factor found in natural latex of the Malaysian rubber tree.. Competitive immunoinhibition tests showed that the starch powder covering the finished gloves is the airborne carrier of the allergen, resulting in bronchial asthma on inhalation. The purified allergen can induce allergic reactions in the nanogram range.. The identification of the allergen (Hev b I) may help to eliminate it during the production of latex-based articles in the future.

Topics: Allergens; Amino Acid Sequence; Antigens, Plant; Blood Proteins; Chromatography, Ion Exchange; Drug Hypersensitivity; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Humans; Latex; Molecular Sequence Data; Plant Proteins; Proteins; Sodium Dodecyl Sulfate

The skin is more susceptible to irritation when an active eczematous process is present. This reduced threshold to irritation occurs in skin distant from the site of the eczematous skin. Data is presented to demonstrate the appearance of irritant dermatitis to lower concentrations of sodium lauryl sulfate during the presence of an allergic contact dermatitis in the guinea pig.

Topics: Animals; Dermatitis, Atopic; Dermatitis, Contact; Dinitrochlorobenzene; Drug Hypersensitivity; Female; Guinea Pigs; Patch Tests; Skin; Sodium Dodecyl Sulfate

Experiments in passive transfer of nickel allergy require highly sensitive guinea pigs and a reliable and technically usable test method. A comparison was made between two sensitization methods, the guinea pig maximization test of MAGNUSSON and KLIGMAN (MK) and a combined injection and painting method devised by POLAK and TURK (PT). Intradermal injection was chosen as test method. The reactions to the test were greater than those of normal animals and the differences were statistically significant. With testing before the start of sensitization it was found difficult to obtain highly sensitive animals (tolerance). PT painting resulted in rather higher sensitivity with Triton X-100 than with sodium lauryl sulphate. In a comparison between the MK and PT methods, no difference in effectiveness was found provided that the animals had not been pretested. Repeated PT injections and paintings caused a further increase of the sensitivity, but the toxicity of nickel is a limiting factor.

Topics: Administration, Topical; Animals; Dermatitis, Contact; Dose-Response Relationship, Drug; Drug Hypersensitivity; Female; Guinea Pigs; Immune Tolerance; Immunization; Immunization, Passive; Injections, Intradermal; Intradermal Tests; Nickel; Polyethylene Glycols; Skin Tests; Sodium Dodecyl Sulfate

Topics: Adult; Benzalkonium Compounds; Cantharidin; Croton Oil; Drug Hypersensitivity; Eczema; Female; Hand Dermatoses; Humans; Hydrochloric Acid; Irritants; Male; Mercury; Middle Aged; Occupations; Phenols; Potassium; Saponins; Sex Factors; Skin; Skin Tests; Sodium Dodecyl Sulfate; Thigh; Trichloroacetic Acid

Topics: Alkaline Phosphatase; Bilirubin; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Drug Hypersensitivity; Erythromycin; Erythromycin Estolate; Hepatitis A; Jaundice; Liver Diseases; Liver Function Tests; Sodium Dodecyl Sulfate; Toxicology; Transaminases

Topics: Drug Hypersensitivity; Erythromycin; Liver Diseases; Sodium Dodecyl Sulfate