sodium-dodecyl-sulfate and Cicatrix--Hypertrophic

Unpredictable hypertrophic scarring (HS) occurs after approximately 35% of all surgical procedures and causes significant physical and psychological complaints. Parallel to the need to understanding the mechanisms underlying HS formation, a prognostic tool is needed. The objective was to determine whether (systemic) immunological differences exist between patients who develop HS and those who develop normotrophic scars (NS) and to assess whether those differences can be used to identify patients prone to developing HS. A prospective cohort study with NS and HS groups in which (a) cytokine release by peripheral blood mononuclear cells (PBMC) and (b) the irritation threshold (IT) after an irritant (sodium lauryl sulphate) patch test was evaluated. Univariate regression analysis of PBMC cytokine secretion showed that low MCP-1, IL-8, IL-18 and IL-23 levels have a strong correlation with HS (P < .010-0.004; AUC = 0.790-0.883). Notably, combinations of two or three cytokines (TNF-a, MCP-1 and IL-23; AUC: 0.942, Nagelkerke R

Topics: Adult; Area Under Curve; Case-Control Studies; Chemokine CCL2; Cicatrix, Hypertrophic; Cytokines; Humans; Interleukin-18; Interleukin-23; Interleukin-8; Leukocytes, Mononuclear; Middle Aged; Patch Tests; Predictive Value of Tests; Prognosis; Prospective Studies; ROC Curve; Skin Irritancy Tests; Sodium Dodecyl Sulfate; Tumor Necrosis Factor-alpha