sodium-dichloroacetate and Breast-Neoplasms

sodium-dichloroacetate has been researched along with Breast-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for sodium-dichloroacetate and Breast-Neoplasms

Article	Year
Unexpected Discovery of Dichloroacetate Derived Adenosine Triphosphate Competitors Targeting Pyruvate Dehydrogenase Kinase To Inhibit Cancer Proliferation. Journal of medicinal chemistry, 2016, Apr-14, Volume: 59, Issue:7 Pyruvate dehydrogenase kinases (PDKs) have recently emerged as an attractive target for cancer therapy. Herein, we prepared a series of compounds derived from dichloroacetate (DCA) which inhibited cancer cells proliferation. For the first time, we have successfully developed DCA derived inhibitors that preferentially bind to the adenosine triphosphate (ATP) pocket of PDK isoform 1 (PDK1). Topics: Adenosine Triphosphate; Apoptosis; Breast Neoplasms; Cell Proliferation; Dichloroacetic Acid; Drug Discovery; Female; Flow Cytometry; Humans; Membrane Potential, Mitochondrial; Phosphorylation; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Tumor Cells, Cultured	2016

Article

Year

Unexpected Discovery of Dichloroacetate Derived Adenosine Triphosphate Competitors Targeting Pyruvate Dehydrogenase Kinase To Inhibit Cancer Proliferation.

Journal of medicinal chemistry, 2016, Apr-14, Volume: 59, Issue:7

Pyruvate dehydrogenase kinases (PDKs) have recently emerged as an attractive target for cancer therapy. Herein, we prepared a series of compounds derived from dichloroacetate (DCA) which inhibited cancer cells proliferation. For the first time, we have successfully developed DCA derived inhibitors that preferentially bind to the adenosine triphosphate (ATP) pocket of PDK isoform 1 (PDK1).

Topics: Adenosine Triphosphate; Apoptosis; Breast Neoplasms; Cell Proliferation; Dichloroacetic Acid; Drug Discovery; Female; Flow Cytometry; Humans; Membrane Potential, Mitochondrial; Phosphorylation; Protein Serine-Threonine Kinases; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Tumor Cells, Cultured

2016