sodium-cyanate has been researched along with Fever* in 2 studies
2 other study(ies) available for sodium-cyanate and Fever
| Article | Year |
|---|---|
Prooxidant-antioxidant state after administration of lipopolysaccharide during correction of the L-arginine-NO system and affinity of hemoglobin for oxygen.
We studied the effect of correction of the L-arginine-NO system on the fever reaction and prooxidant-antioxidant state in rats with increased hemoglobin oxygen affinity caused by sodium cyanate after intramuscular injection of lipopolysaccharide. The imbalance between parameters of the prooxidant-antioxidant state in rats with increased hemoglobin oxygen affinity was least pronounced after lipopolysaccharide administration. Correction of the L-arginine-NO system in rats with increased hemoglobin oxygen affinity had no effect on the contents of Schiff bases and antioxidants after lipopolysaccharide administration. Topics: Animals; Antioxidants; Arginine; Cyanates; Enzyme Inhibitors; Fever; Hemoglobins; Lipid Peroxidation; Lipopolysaccharides; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroglycerin; Oxidation-Reduction; Oxygen; Oxyhemoglobins; Rats; Salmonella Infections, Animal; Vasodilator Agents | 2001 |
High hemoglobin affinity to oxygen and its relationships with lipid peroxidation during fever.
The effects of high hemoglobin-oxygen affinity (HOA) on rectal temperature and lipid free radical oxidation were investigated in red blood cells, heart, liver and kidneys of male rats during fever. Fever was induced by intraperitoneal injection of Salmonella typhi lipopolysaccharide (LPS; 5.0 mg kg(-1)). HOA was increased by addition of 0.5% sodium cyanate to drinking water for eight weeks. HOA modification (actual half-saturation oxygen pressure, P50act, decreased to 23.3+/-0.7 vs. 31.6+/-0.7 Torr in control; p < 0.001) weakened a febrile response: rise of temperature after 4 hours was 0.79+/-0.2 degrees C vs. 1.38+/-0.1 degrees C in rats with normal HOA (p < 0.05). In red cells and tissues of rats with normal HOA, concentrations of conjugated dienes and Schiff bases increased during fever, and alpha-tocopherol level and catalase activity decreased. Rats with increased HOA had an inverse pattern of such changes. Changes in rectal temperature and markers of free radical oxidation correlated with a shift of oxyhemoglobin dissociation curve leftwards. The present results indicate that the intentional increment of HOA may substantially diminish lipid peroxidation activity, increase the body antioxidant content during fever and decrease the febrile response on LPS. Topics: Animals; Antioxidants; Cyanates; Erythrocytes; Fever; Free Radicals; Hemoglobins; Kidney; Lipid Peroxidation; Lipopolysaccharides; Liver; Male; Myocardium; Oxygen; Rats | 1999 |