sodium-bromate and Hearing-Loss--Sensorineural

Acute renal failure with hearing loss due to sodium bromate intoxication is described. A 48-year-old woman who ingested permanent wave neutralizer in a suicide attempt and developed anuria was admitted to our hospital for hemodialysis. Bromate intoxication was suspected and hemodialysis was carried out; she required maintenance dialysis 3 times a week. Irreversible severe sensorineural hearing loss continued and peripheral polyneuropathy developed in the lower limbs. We measured the concentration of bromine in the serum before and after the first hemodialysis and found its removal rate to be 61.3%. This is the first report that proved the utility of hemodialysis for bromate intoxication in a clinical setting.

Topics: Acute Kidney Injury; Bromates; Female; Hearing Loss, Sensorineural; Humans; Middle Aged; Renal Dialysis; Sodium Compounds; Suicide, Attempted

Sodium bromate is a strong oxidant, and bromate intoxication can cause irreversible severe-to-profound sensorineural hearing loss. This paper reports the first case in the English literature of bromate-induced hearing loss with hearing recovery measured by formal audiological assessment.Case reportA 72-year-old woman was admitted to hospital with complaints of profound hearing loss, nausea, diarrhoea and anuria after bromate ingestion in a suicide attempt. On admission, pure tone audiometry and auditory brainstem responses showed profound bilateral deafness. Under the diagnosis of bromate-induced acute renal failure and sensorineural hearing loss, continuous haemodiafiltration was performed. When dialysis was discontinued, pure tone audiometry and auditory brainstem responses showed partial threshold recovery from profound deafness.. Severe-to-profound sensorineural hearing loss is a common symptom of bromate intoxication. Bromate-induced hearing loss may be partially treated, and early application of continuous haemodiafiltration might be useful as a treatment for this intractable condition.

Topics: Acute Kidney Injury; Aged; Audiometry, Pure-Tone; Bromates; Evoked Potentials, Auditory, Brain Stem; Female; Hearing Loss, Sensorineural; Humans; Recovery of Function; Renal Dialysis; Sodium Compounds; Suicide, Attempted; Treatment Outcome

Topics: Acute Kidney Injury; Bromates; Charcoal; Female; Gastric Lavage; Hearing Loss, Sensorineural; Hemodiafiltration; Humans; Middle Aged; Respiration, Artificial; Sodium Compounds; Suicide, Attempted; Thiosulfates; Treatment Outcome

Topics: Adult; Bromates; Female; Hearing Loss, Sensorineural; Humans; Polyneuropathies; Sodium Compounds