sodium-bisulfite and Drug-Hypersensitivity

Topics: Anesthesia, Dental; Anesthetics, Local; Child; Dental Care for Children; Drug Delivery Systems; Drug Hypersensitivity; Drug Overdose; Epinephrine; Humans; Latex Hypersensitivity; Parabens; Sulfites

Provocative oral tests with 1000 mg of the sulfite chemicals produced allergic reactions in 10% of the patients tested. Parenteral therapy with an Allpyral extract of the sulfite chemicals was instituted. After 3 months' therapy three patients were challenged with 1000 mg of the sulfite chemicals and modified attacks of asthma were produced. After 6 months' therapy the same three patients failed to react. Therefore, I rechecked all patients after 6 or more months of therapy. Thirty-five patients were retested; 29 failed to react and six reacted with allergic symptoms. The 29 patients no longer reacted to foods treated with the sulfite chemicals.

Topics: Child; Desensitization, Immunologic; Drug Hypersensitivity; Humans; Nausea; Sulfites; Vomiting

The purpose of this work is to present an accurate and safe method to determine clinical sensitivity to the sulfite chemicals used in our food supply. This was done by oral challenge tests using 1500 mg of the chemicals on an empty stomach.

Topics: Administration, Oral; Drug Hypersensitivity; Humans; Sulfites