sodium-bicarbonate and Urinary-Tract-Infections

A group of 324 patients received prophylactic treatment with either sodium bicarbonate, potassium citrate or a glucose placebo following urodynamic studies. Urine was screened for infection both before and after testing and the incidence of dysuria assessed by postal questionnaire; 63% of patients experienced some degree of dysuria and this was severe and prolonged in 6.3%, the majority of whom were male. Neither sodium bicarbonate nor potassium citrate was any more effective in preventing dysuria than placebo. The presence of severe prolonged dysuria was not associated with a urinary tract infection or with any particular urodynamic diagnosis.

Topics: Bacteriuria; Bicarbonates; Citrates; Citric Acid; Female; Hematuria; Humans; Male; Sodium; Sodium Bicarbonate; Urinary Tract Infections; Urination Disorders; Urodynamics; Urologic Diseases

68 women with acute, uncomplicated urinary tract infection confirmed bacteriologically were randomized to receive either a single oral dose of cotrimoxazole, a single oral dose of amoxycillin, or an oral dose of Na-bicarbonate. Results comparable to previous reports were obtained with the cotrimoxazole regimen. On the other hand, the efficacy of single-dose amoxycillin appeared to be inferior. It is possible that pharmacocinetic differences influence the efficacy of these drugs.

Topics: Adult; Ambulatory Care; Amoxicillin; Bicarbonates; Clinical Trials as Topic; Drug Administration Schedule; Female; Humans; Middle Aged; Placebos; Random Allocation; Sodium Bicarbonate; Sulfamethoxazole; Trimethoprim; Urinary Tract Infections

Topics: Adolescent; Adult; Aged; Amoxicillin; Bicarbonates; Double-Blind Method; Drug Combinations; Drug Evaluation; Female; Humans; Middle Aged; Penicillin Resistance; Random Allocation; Sodium Bicarbonate; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Urinary Tract Infections

We compared the effect of commercial vaginal douching products on Lactobacillus crispatus, L. jensenii, L. gasseri, L. iners, E. coli, and immortalized vaginal epithelial cells (VK2). All studied douching products (vinegar, iodine and baking soda based) induced epithelial cell death, and all inhibited growth of E. coli. Co-culture of vaginal epithelial cells with any of the lactobacilli immediately following exposure to douching products resulted in a trend to less human cell death. However, co-culture of epithelial cells with L. iners was associated with higher production of IL6 and IL8, and lower IL1RA regardless of presence or type of douching solution. Co-culture with L. crispatus or L. jensenii decreased IL6 production in the absence of douches, but increased IL6 production after exposure to vinegar. Douching products may be associated with epithelial disruption and inflammation, and may reduce the anti-inflammatory effects of beneficial lactobacilli.

Topics: Acetic Acid; Cell Survival; Coculture Techniques; Cytokines; Epithelium; Escherichia coli; Female; Humans; Hydrogen-Ion Concentration; Immune System; Interleukin-6; Interleukin-8; Iodine; Lactobacillus; Lactobacillus crispatus; Lactobacillus gasseri; Microbial Sensitivity Tests; Risk; Sodium Bicarbonate; Urinary Tract Infections; Vagina; Vaginal Douching

Topics: Acidosis, Lactic; Acute Kidney Injury; Anti-Bacterial Agents; Comorbidity; Female; Humans; Hypothermia; Infusions, Intravenous; Metformin; Middle Aged; Multiple Organ Failure; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Renal Replacement Therapy; Sodium Bicarbonate; Urinary Tract Infections; Vasoconstrictor Agents

We analyzed 20 cases of urinary fungal infection experienced at our Department, during the last 2 years. Candida albicans was the most prevalent of the fungi affecting the urinary tract. Torulopsis glabrata and Candida tropicalis were also prevalent. Antibiotics, indwelling catheter and obstructive uropathy were the most prevalent predisposing factors of the fungal infection. Of 20 cases of fungal infection, 5 cases were cured only by elimination of the predisposing factors, and 15 cases were treated and resolved by administration of sodium bicarbonate, 5-fluorocytosine and or irrigation with amphotericin B. But one case of bilateral renal torulopsiosis developed into renal failure, and 4 cases died of the primary disease.

Topics: Adolescent; Adult; Aged; Amphotericin B; Anti-Bacterial Agents; Bicarbonates; Candida; Candidiasis; Child; Child, Preschool; Female; Flucytosine; Humans; Infant; Male; Middle Aged; Mycoses; Sodium; Sodium Bicarbonate; Urinary Catheterization; Urinary Tract Infections