sodium-bicarbonate and Syndrome

Belching, flatulence, abdominal distention, and gas pains are common symptoms that may stimulate concern for the patient and from the physician. An understanding of the pathophysiology of intestinal gas syndromes should permit a more focused diagnostic and therapeutic approach.

Topics: Abdominal Pain; Eructation; Flatulence; Gases; Humans; Intestines; Sodium Bicarbonate; Syndrome

Topics: Adolescent; Adult; Aldosterone; Bicarbonates; Blood Pressure; Child; Diet, Sodium-Restricted; Diuretics; Female; Glomerular Filtration Rate; Humans; Hyperkalemia; Hypertension; Kidney Tubules; Male; Mannitol; Middle Aged; Mineralocorticoids; Potassium; Renin; Sodium; Sodium Bicarbonate; Syndrome

To compare the clinical efficacy of alginate drug Geviskon and aluminum-magnesium antacids to relieve symptoms of esophageal, extraesophageal syndrome and functional dyspepsia at 3 and 7 days of study in patients with GERD elderly.. An open, longitudinal, randomized, parallel-group. The study included 60 patients with "A" degree of ERD, consistently received in-patient treatment in the Municipal KGVV, mean age 79.0 +/- 6.8 years. During the first 12 hours of hospital stay by "sealed envelopes" them randomly divided into equal groups of comparison, given 3 times a day: alginate product--Geviskon forte dose of 10 ml and aluminum-magnesium antacid drug at a dose of 1 sachet. Assess the frequency and severity of esophageal symptoms, extraesophageal syndrome, functional dyspepsia at 3 and 7 days of study on 5-point scale Likert. The degree of esophageal mucosal injury was determined during endoscopy before the study.. The technique of alginate compared with antacids provided significantly more complete and earlier effect on the relief of heartburn, regurgitation, chronic cough, sore throat, and EBS. Only Geviskon influenced the symptoms of PPD in patients with GERD.. The clinical features Geviskon the frequency and timing of relief of symptoms of esophageal, extraesophageal syndrome, functional dyspepsia with GERD in the older age groups is higher than that of antacids. Suspension Geviskon may be recommended in patients with middle and old age as an effective and safe symptomatic funds in the first days of exchange rate earlier generations of PPI therapy, as well as monotherapy--to maintain remission.

Topics: Aged; Aged, 80 and over; Alginates; Aluminum Hydroxide; Antacids; Cough; Drug Combinations; Dyspepsia; Female; Gastroesophageal Reflux; Humans; Laryngitis; Male; Middle Aged; Silicic Acid; Sodium Bicarbonate; Syndrome; Treatment Outcome

Insulin autoimmune syndrome is a rare cause of hyperinsulinemic hypoglycemia characterized by autoantibodies to human insulin without previous insulin use. We report a case of a patient with hyperinsulinemic hypoglycemia possibly caused by insulin antibodies induced by insulin analogs and a novel therapeutic measure for this condition.. An 84-year-old Japanese man with a 28-year history of type 2 diabetes and chronic kidney disease, treated with biphasic insulin aspart 30, experienced persistent early morning hypoglycemia with daytime hyperglycemia. Despite discontinuation of biphasic insulin aspart 30, the condition persisted even after the patient ate small, frequent meals. Sodium bicarbonate was administered to correct the chronic metabolic acidosis, which then rectified the early morning glucose level.. We believe this to be the first published case of a therapeutic approach to the treatment of hyperinsulinemic hypoglycemia associated with insulin antibodies that factors in blood pH and the correction of acidosis using sodium bicarbonate, which physicians could consider.

Topics: Acidosis; Aged, 80 and over; Alkalies; Autoimmune Diseases; Humans; Hyperinsulinism; Hypoglycemia; Insulin Antibodies; Male; Sodium Bicarbonate; Syndrome

Features consistent with the syndrome known as excited delirium (ExDS) have been associated with law enforcement restraint-related death. The pathophysiology and exact causative factors of restraint-related death associated with ExDS remain unclear. We present a case of successful field resuscitation of a man with ExDS who experienced cardiopulmonary arrest while being restrained by law enforcement officers. Despite the presence of a severe lactic acidosis on emergency department admission, the patient recovered following prehospital treatment with advanced cardiac life support measures and intravenous sodium bicarbonate, likely in part due to early recognition of the disease process.

Topics: Acidosis; Adult; Advanced Trauma Life Support Care; Delirium; Electric Stimulation; Emergency Medical Services; Forensic Medicine; Heart Arrest; Humans; Male; Police; Psychomotor Agitation; Restraint, Physical; Resuscitation; Sodium Bicarbonate; Syndrome

Sodium bicarbonate (NaHCO3) has been used successfully in mammals and birds to alleviate pulmonary hypertension. Experiment 1 was designed to provide measurements of arterial and venous blood-gas values from unanesthetized male broilers subjected to a cool temperature (16 degrees C) challenge and fed either a control diet or the same diet alkalinized by dilution with 1% NaHCO3. The incidences of pulmonary hypertension syndrome (PHS, ascites) for broilers fed the control or bicarbonate diets were 15.5 and 10.5%, respectively (P = 0.36, NS). Non-ascitic broilers fed the control diet were heavier than those fed the bicarbonate diet on d 49 (2,671 vs. 2,484 g, respectively); however, other comparisons failed to reveal diet-related differences in heart weight, pulse oximetry values, electrocardiogram amplitudes, or blood-gas values (P > 0.05). When the data were resorted into categories based on right:total ventricular weight ratios (RV:TV) indicative of normal (RV:TV < 0.28) or elevated (RV:TV > or = 0.28) pulmonary arterial pressures, broilers with elevated RV:TV ratios had poorly oxygenated arterial blood that was more acidic, had high partial pressure of CO2 (PCO2), and had higher HCO3 concentrations when compared with broilers with normal RV:TV ratios. Experiment 2 was conducted to determine if metabolic variations associated with differences in feed intake or environmental temperature potentially could mask an impact of diet composition on blood-gas values. Male broilers maintained at thermoneutral temperature (24 degrees C) either received feed ad libitum or had the feed withdrawn > or = 12 h prior to blood sampling. Broilers fed ad libitum had lower venous saturation of hemoglobin with O2, higher venous PCO2, and higher arterial HCO3 concentrations than broilers subjected to feed withdrawal. Broilers in experiment 2 fed ad libitum and exposed to cool temperatures (16 degrees C) had lower arterial partial pressure of O2 and higher venous PCO2 than broilers fed ad libitum and maintained at 24 degrees C. Overall, these results demonstrate that changes in diet composition (control vs. 1% NaHCO3 diets) had minimal impact on arterial and venous blood-gas variables when compared with the more dramatic differences associated with feed intake (ad libitum vs. > or = 12 h withdrawal), environmental temperature (24 vs. 16 degrees C), and the pathogenesis associated with PHS (RV:TV < 0.28 vs. > or = 0.28).

Topics: Acid-Base Equilibrium; Animals; Ascites; Blood Gas Analysis; Carbon Dioxide; Chickens; Cold Temperature; Food Deprivation; Hydrogen-Ion Concentration; Hypertension, Pulmonary; Incidence; Male; Oxygen; Partial Pressure; Poultry Diseases; Pulmonary Artery; Random Allocation; Sodium Bicarbonate; Syndrome

Familiar hypomagnesemia with hypercalciuria and nephrocalcinosis is a rare syndrome belonging to the group of heterogeneous tubular diseases whose common characteristic is renal magnesium wasting. We present a 9 year old boy with polyuria, polydipsia and enuresis. Radiologic and ultrasonographic examinations showed nephrocalcinosis. Hypomagnesemia, normokaliemia, hypermagnesiuria, hypercalciuria, incomplete distal tubular acidosis, hypocitraturia and mild renal failure were found. Treatment with magnesium salts, hydrochlorothiazide, potassium citrate and sodium bicarbonate did not restore magnesium or calcium levels to normal. Renal function and nephrocalcinosis remain stable after 3 year's treatment. In conclusion, we report a new case of this rare syndrome caused by a congenital defect in magnesium reabsorption and discuss the evolution of the illness during 3 years' treatment.

Topics: Adolescent; Calcium; Child; Diuretics; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Magnesium; Male; Nephrocalcinosis; Potassium Citrate; Sodium Bicarbonate; Syndrome; Time Factors; Urography

Although cocaine is one of the leading causes of drug-related deaths, there is little clinical information describing the precise sequence of events leading to death in the cocaine intoxication. Usually, cocaine-related sudden deaths are unwitnessed, its electrocardiographic features are not attainable, and the majority of these patients have a rapidly fatal course and die before arriving at the hospital. We report a patient with massive cocaine ingestion who developed psychomotor agitation and generalized seizures followed by asystolic cardiac arrest. Ventilation with supplemental oxygen by endotracheal intubation immediately restored spontaneous heart beat. After resuscitation, a severe metabolic acidosis (pH 6.65) and cardiac dysrrhythmias consistent with sodium channel poisoning were detected. The electrocardiogram showed accelerated junctional rhythm at 85 beats/min with right bundle branch block and left anterior hemiblock configuration, prolongation of QRS (0.16 sec) and QTc (0.52 sec) intervals, and terminal J wave associated with coved ST-segment elevation in leads V(1) and V(2) resembling the Brugada syndrome. Sodium bicarbonate administration was quickly followed by normalization of the cardiac conduction disturbances. This article discusses the clinical and electrophysiologic implications of these findings.

Topics: Acidosis; Adult; Cocaine; Death, Sudden, Cardiac; Dopamine Uptake Inhibitors; Electrocardiography; Heart Arrest; Heart Conduction System; Humans; Male; Sodium Bicarbonate; Syndrome

Post-reperfusion syndrome is the most common hemodynamic pattern in liver transplantation, manifesting mainly through decreased heart rate, mean arterial pressure and systemic vascular resistances. Five factors have been implicated in its genesis: the heart, the circulatory system, the metabolism, reflexes and surgery. Ventricular function, both right and left, has been shown to be normal during reperfusion, in which case the visceral and, especially, liver dilation that occurs would be the main cause of arterial hypotension. Patients in poor physical condition before the transplant are more likely to suffer the syndrome. Surgical technique (standard, venovenous shunt or preservation of the inferior vena cava), on the other hand, does not seem to play a major role. Prophylaxis with atropine prevents bradycardia but not hypotension. Administration of calcium chloride and sodium bicarbonate together with hyperventilation, mitigates symptoms. Finally, treatment with phenylephrine is rapidly effective.

Topics: Body Temperature; Calcium Chloride; Disease Susceptibility; Hemodynamics; Humans; Liver Transplantation; Models, Biological; Phenylephrine; Prognosis; Reflex; Reperfusion Injury; Sodium Bicarbonate; Splanchnic Circulation; Syndrome; Vasodilation

A syndrome of metabolic acidosis of unknown etiology was diagnosed in twelve beef calves 7 to 31 days old. Principal clinical signs were unconsciousness or depression concomitant with weakness and ataxia. Other signs included weak or absent suckle and menace reflexes, succussable nontympanic fluid sounds in the anterior abdomen, and a slow, deep thoracic and abdominal pattern of respiration. The variation in clinical signs between calves was highly correlated (r = 0.87, P less than 0.001) with their acid-base (base deficit) status. Abnormal laboratory findings included reduced venous blood pH, pCO2 and bicarbonate ion concentration as well as hyperchloremia, elevated blood urea nitrogen, increased anion gap and neutrophilic leukocytosis with a left shift. Sodium bicarbonate solution administered intravenously effectively raised blood pH and improved demeanor, ambulation and appetite. All calves did well following a return to a normal acid-base status.

Topics: Acidosis; Animals; Animals, Newborn; Bicarbonates; Cattle; Cattle Diseases; Female; Fluid Therapy; Male; Sodium; Sodium Bicarbonate; Sodium Chloride; Syndrome

Topics: Acute Kidney Injury; Bicarbonates; Dopamine; Furosemide; Humans; Rhabdomyolysis; Sodium; Sodium Bicarbonate; Syndrome