sodium-bicarbonate and Skin-Neoplasms

Intralesional vinblastine has been used to treat Kaposi's sarcoma associated with acquired immunodeficiency syndrome (AIDS-KS). Injections are painful and anticipated response rates are not well documented.. Eleven homosexual men were studied to evaluate the efficacy and pain associated with intralesional vinblastine with or without 1% bicarbonate buffered lidocaine (BBL).. Six lesions on each patient were selected and treated with either vinblastine, vinblastine mixed with BBL, or vinblastine 5 minutes after BBL injection. Control lesions received BBL, saline, or no treatment. Patients recorded injection pain on a visual analog scale.. There was a complete or partial clinical response in 88% of vinblastine-treated lesions. Pain scores for BBL, vinblastine, and the mixture of BBL and vinblastine were not statistically different.. Intralesional vinblastine is effective therapy for AIDS-KS. Local anesthesia does not reduce efficacy of treatment, or reduce the pain experienced by the patient.

Topics: Acquired Immunodeficiency Syndrome; Adult; Bicarbonates; Buffers; Humans; Injections, Intralesional; Lidocaine; Male; Pain; Sarcoma, Kaposi; Skin Neoplasms; Sodium; Sodium Bicarbonate; Vinblastine

To investigate the role of swelling anesthesia in repairing facial soft tissue defects after tumor resection and temporal superficial artery frontal branch of narrow pedicle flap.. From January 2008 to June 2008, 16 patients from Department of Ophthalmology with eye or eyelid tumors after eyeball removal of eye and part resection of surrounding soft tissue, undergoing postoperative swelling anesthesia with superficial temporal artery flap repair to prevent facial soft tissue defect formation and bone exposure, were recruited.. In all 16 patients facial soft tissue defect repair had good effects, with limited bleeding, and short operation times. Seven days after surgery, all flaps were in good repair. On postoperative follow-up after 3 months, flaps showed a similar appearance as with facial tissue.. Swelling anesthesia for superficial temporoparietal artery frontal branch of narrow pedicle flap to repair soft tissue defect after facial tumor resection is feasible, and is linked with good analgesic effects, high postoperative survival of skin flaps, and good cosmetic effects.

Topics: Aged; Aged, 80 and over; Anesthetics, Local; Dermatologic Surgical Procedures; Epinephrine; Eye Neoplasms; Eyelid Neoplasms; Feasibility Studies; Female; Forehead; Humans; Injections, Subcutaneous; Isotonic Solutions; Male; Skin Neoplasms; Sodium Bicarbonate; Sodium Chloride; Soft Tissue Neoplasms; Surgical Flaps; Vasoconstrictor Agents

Basal cell carcinomas (BCC) are caused by various factors such as ultraviolet light, ionizing radiation, possibly human papilloma viruses and chemical agents. Among the latter inorganic trivalent arsenic has long been recognized as an important cause of BCC. A 70-year-old woman developed multiple basal cell carcinomas mainly on the trunk after taking sodium hydrogen carbonate contaminated with arsenic for many years for chronic gastritis.

Topics: Aged; Arsenic; Female; Gastritis; Humans; Long-Term Care; Neoplasms, Multiple Primary; Risk Factors; Self Medication; Skin; Skin Neoplasms; Sodium Bicarbonate