sodium-bicarbonate and Gingivitis

Previous studies demonstrated a dose-dependent efficacy of sodium bicarbonate when added to dentifrices for the mechanical control of dental biofilm. The present systematic review and meta-analysis aimed to evaluate the efficacy of a 67% sodium bicarbonate-based toothpaste for gingival health parameters improvement in subjects with gingivitis.. An electronic search on MEDLINE, Scopus, and Cochrane Central Register of Controlled Trials (CENTRAL), was performed using a combination of keywords, followed by a hand search on pertinent Journals. Randomized controlled trials (RCTs) and prospective comparative studies in English language were included. There was no publication date and language restriction. The data regarding gingival, bleeding, and plaque index were extracted from the selected studies. Included studies underwent risk-of-bias assessment. When at least 3 studies reporting the same outcome were found, a meta-analysis was undertaken, to estimate the combined effect. Trial Sequential Analysis (TSA) was also performed to evaluate the power of the meta-analysis for primary outcomes.. The search strategy yielded 83 articles. After screening, 7 RCTs were included. Three were at high risk, one at moderate risk, and 3 at low risk-of-bias. Significant improvement of gingival index, bleeding index, and plaque index was observed in patients using 67% sodium bicarbonate toothpaste as compared with control subjects. TSA showed sufficient power for modified Gingival index and bleeding scores.. The clinical use of 67% sodium bicarbonate toothpaste can improve periodontal health in patients with gingivitis.

Topics: Dental Plaque; Dental Plaque Index; Double-Blind Method; Gingivitis; Humans; Sodium Bicarbonate; Toothpastes

To test the efficacy of a dentifrice containing baking soda (BS), compared with dentifrice without BS for controlling plaque and gingivitis.. MEDLINE-PubMed and Cochrane-CENTRAL were searched. The inclusion criteria were randomized controlled clinical trials including healthy participants aged 18 years or older. Studies were selected that compared the effect of toothbrushing with a dentifrice with and without BS on the clinical parameters of plaque and gingivitis. Data were extracted from the selected studies, and a meta-analysis was performed.. The search retrieved 21 eligible publications. Among these papers, 43 comparisons were provided, with 23 involving a single-use design and 20 being evaluations with a follow-up. Negative controls were found, or positive controls for which various active ingredients had been used. The included studies showed a moderate overall potential risk of bias and considerable heterogeneity. The meta-analysis of plaque scores from the single-brushing experiments showed that BS dentifrice (BS-DF) was associated with significantly better outcomes than the negative control dentifrices (DiffM -0.20; P < 0.0001; 95% CI: [-0.27; -0.12]) or the positive control dentifrices (DiffM -0.18; P < 0.0001; 95% CI: [-0.24; -0.12]). This finding was only confirmed in studies that used a follow-up design as compared to a negative control (DiffM -0.19; P = 0.01; 95% CI: [-0.34; -0.04]). The indices of gingival bleeding also improved when the comparison was a negative control (DiffM -0.08; P = 0.02; 95% CI: [-0.16; -0.01] and (DiffM -0.13; P < 0.001; 95% CI: [-0.18; -0.08]. However, for the gingival index scores, the meta-analysis did not reveal any significant differences.. BS-DF showed promising results with respect to plaque removal in single-use studies. However, the finding was partially substantiated in follow-up studies. Studies that assessed bleeding scores indicated that a small reduction can be expected from BS, relative to a control product.

Topics: Databases, Bibliographic; Dental Plaque; Dentifrices; Gingivitis; Humans; Randomized Controlled Trials as Topic; Sodium Bicarbonate; Toothbrushing

Mechanical disruption of dental biofilm is critical to maintain periodontal health. Baking soda-containing dentifrices have shown to be potential aids for improving gingival health and maintaining dental biofilm control.. Evidence from classic and contemporary literature is reviewed and summarized in this review. In vitro and in vivo (animal and human, respectively) studies and clinical trials have been analyzed.. Some clinical studies demonstrated the benefits of baking soda dentifrices in plaque and gingivitis reduction. Clinical trials with longer follow-up would be useful to confirm the impact of baking soda on gingival health.. Regular dental biofilm control and adjunctive use of baking soda dentifrices in an otherwise healthy and compliant patient may provide success in maintenance of gingival health.

Topics: Animals; Biofilms; Dental Plaque; Dentifrices; Gingivitis; Humans; Periodontal Diseases; Periodontium; Sodium Bicarbonate

Topics: Alkaloids; Benzoates; Benzophenanthridines; Benzydamine; Cetylpyridinium; Chlorhexidine; Dental Plaque; Drug Combinations; Fluorides; Gingivitis; Isoquinolines; Mouthwashes; Peroxides; Salicylates; Sodium Bicarbonate; Sodium Dodecyl Sulfate; Terpenes; Triclosan

To assess the anti-plaque effect of a high concentration sodium bicarbonate dentifrice on plaque formation, and gingivitis, as compared to a control toothpaste, irrespective of individual brushing technique and plaque quality.. The experimental gingivitis model, with a split-mouth design was used to assess the anti-plaque effect of a high concentration sodium bicarbonate dentifrice on plaque formation. By producing individual fitted trays, the toothpaste was applied in the test quadrant and a control dentifrice in the contralateral. The participants used the individual fitted trays for 1 min every morning and evening, for 21 days. In this period, the participants was only allowed to brush the teeth in the opposite jaw, as usual. Twenty healthy individuals successfully completed the study.. At 21 days, there was no statistically significant difference between test quadrant and control quadrant with regard to plaque indices, gingival index and number of bleeding sites.. This study demonstrated that the high concentration sodium bicarbonate dentifrice used did not produce statistically significant anti-plaque effect compared to the control dentifrice, in terms of Plaque- and Gingival Indices, number of bleeding sites or by Quigely and Hein, the Turesky modification Plaque Index, irrespective of brushing technique and individual plaque quality.. Regional Committee for Medical Research and Ethics, South-East Norway in 2021 (REK.2021/370116).. NCT05441371 (First registered 09/06/2022, First posted 01/07/2022) ( http://www.. gov ). (Retrospectively registered).

Topics: Bicarbonates; Dental Plaque; Dental Plaque Index; Dentifrices; Double-Blind Method; Gingivitis; Humans; Inflammation; Sodium Bicarbonate; Toothpastes

This randomised, examiner-blind, parallel study compared gingival bleeding and plaque control following 12 weeks' twice-daily use of 67%, 62% or 0% sodium bicarbonate (NaHCO3)-containing toothpastes.. Adults with mild-to-moderate gingivitis, ≥ 20 gingival bleeding sites and bleeding after brushing were randomised to toothpastes containing 923 ppm sodium fluoride and either 67% NaHCO3, 62% NaHCO3 + 5% w/w silica, or 0% NaHCO3. Gingival bleeding was assessed with the Saxton and van der Ouderaa Bleeding Index (BI), plaque was assessed with the Turesky modification of the Quigley-Hein Plaque Index (TPI).. There were significantly fewer bleeding sites at Week 12 (primary endpoint) for 67% NaHCO3 (n = 110) and 62% NaHCO3 (n = 110) groups compared with the 0% NaHCO3 group (n = 110) (treatment differences: -3.1 [97.5% confidence interval (CI) -5.5, -0.7] P = 0.0068 and -2.4 [-4.8, 0.0] P = 0.0448, respectively). Statistically significant differences were also seen at Week 6 (P = 0.0361 for 67% NaHCO3, P = 0.0044 for 62% NaHCO3 compared to 0% NaHCO3). Compared with the 0% NaHCO3 group, BI was significantly lower in the 67% NaHCO3 group at Weeks 6 and 12 (P = 0.0477 and P = 0.0066, respectively). TPI was significantly lower in the 67% NaHCO3 and 62% NaHCO3 groups at Week 6 (P = 0.0336 and 0.0009, respectively) but not at Week 12. No statistically significant differences were found between the 67% NaHCO3 and 62% NaHCO3 toothpastes for any variable. No treatment-related adverse events were reported.. Twice-daily brushing over 12 weeks with toothpastes containing 67% NaHCO3 or 62% NaHCO3 significantly improved plaque control and reduced indices of bleeding in participants with mild-to-moderate gingivitis.

Topics: Adult; Dental Plaque; Dental Plaque Index; Double-Blind Method; Gingivitis; Humans; Sodium Bicarbonate; Toothpastes; Treatment Outcome

To compare the effectiveness in reducing plaque and gingivitis of two fluoride toothpastes containing baking soda (35% and 20%) with a fluoride toothpaste control.. 319 subjects, who met entry criteria, participated in this single-center, three-cell, double-blind, randomized, parallel-group clinical study. Gingival Index (MGI), Gingival Bleeding Index (GBI), and Plaque Index (PI) were assessed at baseline, and after 6 weeks, 3 and 6 months.. All three toothpastes significantly (P< 0.0001) reduced MGI, GBI, and PI versus baseline, and the two baking soda toothpastes significantly (P< 0.0001) reduced MGI, GBI, and PI compared to the fluoride control, at all three time points. After 6 months use, the 35% and 20% baking soda toothpastes had reduced MGI, GBI and PI by 15.0%, 46.9%, and 18.3%, and 9.4%, 25.9%, and 12.4%, respectively, compared to the control. In addition, the 35% baking soda toothpaste had reduced (P≤ 0.0005) MGI, GBI, and PI by 6.2%, 28.4%, and 6.8%, respectively, compared to the 20% baking soda toothpaste. This clinical study showed that brushing with fluoride toothpastes containing baking soda at 35% and 20% reduces plaque, gingival inflammation and bleeding more effectively than regular fluoride toothpaste. Further, it showed that 35% baking soda toothpaste was more effective in reducing these parameters than 20% baking soda toothpaste.. Fluoride toothpastes containing 20% or more baking soda can provide significant and meaningful gingival health benefits when used regularly as an adjunct to tooth brushing.

Topics: Dental Plaque; Dental Plaque Index; Gingivitis; Humans; Sodium Bicarbonate; Toothpastes

To compare the effectiveness in reducing plaque and gingivitis of a fluoride toothpaste with 20% baking soda and a fluoride toothpaste control.. 159 subjects, who met the entry criteria, participated in this single-center, double-blind, randomized, parallel-group clinical study. Gingival Index (MGI), Gingival Bleeding Index (GBI), and Plaque Index (PI) were assessed after 4, 8, and 12 weeks use of the assigned test or control toothpaste. After 12 weeks, participants resumed 4 weeks of their customary oral hygiene after which they were re-evaluated using the same measures.. Both toothpastes statistically significantly reduced MGI, GBI, and PI versus baseline at all-time points. Brushing with the 20% baking soda toothpaste statistically significantly reduced MGI, PI, and GBI compared to the control toothpaste at all time points. After 12 weeks, the reductions in MGI, PI, and GBI were 12.6%, 9.6%, and 44.2%, respectively. After the 4-week customary oral hygiene period, the benefits of the study period had begun to diminish, but statistically significant reductions in MGI and GBI for the test versus control were still evident. This 3-month clinical study shows that brushing with fluoride toothpaste containing 20% baking soda reduces dental plaque and concurrently reduces gingival inflammation and bleeding compared to toothpaste with fluoride alone.. Fluoride toothpaste with 20% baking soda has the potential to offer multiple oral health benefits when used as an adjunct to regular tooth brushing and, therefore, may be confidently recommended to patients.

Topics: Dental Plaque; Dental Plaque Index; Gingivitis; Humans; Sodium Bicarbonate; Toothpastes

Short-term use of sodium bicarbonate (NaHCO3)-containing toothpaste reduces plaque and improves clinical measures of gingivitis. To examine this over a longer period, we compared efficacy and tolerability of twice-daily brushing for 24 weeks with 67% or 0% NaHCO3-containing toothpastes in USA-based participants with moderate gingivitis (Clinicaltrials.gov:NCT02207400).. This was a six-month, randomized, examiner-blind, parallel-group, clinical trial. Investigators randomized adults with blood in expectorate after brushing and ≥ 20 gingival bleeding sites to 67% NaHCO3 (n = 123; n = 107 completed study) or 0% NaHCO3 (n = 123; n = 109 completed study) toothpastes. Primary efficacy variables included between-treatment differences in number of bleeding sites and Modified Gingival Index (MGI) score at 24 weeks. Secondary efficacy variables included Bleeding Index and Turesky modification of the Quigley-Hein Plaque Index (overall and interproximal sites) at six, 12, and 24 weeks. A subset of 50 participants underwent sampling to assess plaque microbiology over the course of treatment.. Compared with the 0% NaHCO3 toothpaste, the 67% NaHCO3 toothpaste produced statistically significant improvements at Week 24 in number of bleeding sites (46.7% difference) and MGI (33.9% difference), and for all other endpoints (all p < 0.0001). There was no significant between-treatment difference in the proportion of participants harboring opportunistic pathogens. Products were generally well tolerated, with two and five treatment-related adverse events reported in the 67% and 0% NaHCO3 toothpaste groups, respectively.. Gingival bleeding, gingivitis, and plaque indices were significantly improved at six, 12, and 24 weeks with twice-daily brushing with 67% NaHCO3-containing toothpaste in participants with moderate gingivitis.

Topics: Adult; Dental Plaque; Dental Plaque Index; Double-Blind Method; Gingivitis; Humans; Periodontal Index; Sodium Bicarbonate; Toothpastes; Treatment Outcome

Sodium bicarbonate (NaHCO3) in toothpaste can enhance the removal of biofilms involved in the development of gingivitis. To examine this over an extended time period, this study compared the efficacy and tolerability of twice-daily brushing for 24 weeks with 67% or 0% NaHCO3-containing toothpastes in subjects with moderate gingivitis.. 247 adults with bleeding after brushing and ≥ 20 gingival bleeding sites were randomized to twice-daily brushing with a 67% NaHCO3 or 0% NaHCO3 toothpaste. The primary efficacy variables were between-treatment differences in number of bleeding sites and the Modified Gingival Index (MGI) score after 24 weeks' use. Secondary efficacy variables included Bleeding Index (BI) and Turesky modification of Quigley-Hein Plaque Index (TPI) (overall and only interproximal sites).. The 67% NaHCO3 toothpaste produced statistically significant improvements compared with the 0% NaHCO3 toothpaste in number of bleeding sites (-17.5; 95% CI -20.32, -14.66; p < 0.0001) and MGI score (-0.2; 95% CI -0.24, -0.17; p < 0.0001) at week 24. These significant differences were also found at 6 and 12 weeks for these measures and at 6, 12, and 24 weeks for BI and TPI scores (including at only interproximal sites) (all p < 0.0001). No treatment-related adverse events were reported.. Twice-daily brushing with 67% NaHCO3 toothpaste was generally well tolerated and significantly improved indices of gingival bleeding and plaque compared with 0% NaHCO3 toothpaste in subjects with moderate gingivitis.

Topics: Adolescent; Adult; Aged; Dental Plaque Index; Female; Gingivitis; Humans; Hydrogen Peroxide; Male; Middle Aged; Patient Acceptance of Health Care; Periodontal Index; Single-Blind Method; Sodium Bicarbonate; Toothbrushing; Toothpastes; Treatment Outcome; Young Adult

In previous studies, toothpastes with high levels of sodium bicarbonate (>50%) have reduced gingival inflammation and oral malodour. This study compared the effects of brushing for 6 weeks with 67% (test group) or 0% (control group) sodium bicarbonate toothpaste on gingival health.. This was a single-centre, single examiner-blind, randomized, controlled, two-treatment, parallel-group study. Eligible subjects (≥18 years) had ≥20 gradable teeth, mild-to-moderate gingivitis, a positive response to bleeding on brushing and ≥20 bleeding sites. The primary objective was to compare the number of bleeding sites following twice-daily use of 67% sodium bicarbonate toothpaste or 0% sodium bicarbonate toothpaste after 6 weeks. Secondary endpoints included Modified Gingival Index (MGI), Bleeding Index (BI) and volatile sulphur compounds (VSC), assessed after 6 weeks. Safety was assessed by treatment-emergent oral soft tissue abnormalities and adverse events.. Of 148 patients randomized (74 to each treatment), 66 (89.2%) completed the study in the test group, compared with 69 (93.2%) in the control group. Compared with the control group, the test group had a significant reduction in the number of bleeding sites at Week 6 (absolute difference - 11.0 [-14.0, -8.0], P < 0.0001; relative difference - 25.4%), together with significant reductions in MGI and BI (both P < 0.0001). Although the median reductions from baseline for VSC were numerically greater in the test group, the difference did not reach statistical significance (P = 0.9701).. This 67% sodium bicarbonate toothpaste provided statistically significant improvements in gingival health and bleeding after 6 weeks of use.

Topics: Adult; Female; Gingivitis; Humans; Male; Single-Blind Method; Sodium Bicarbonate; Toothbrushing; Toothpastes; Treatment Outcome

To investigate the clinical efficacy of three toothpastes in controlling established gingivitis and plaque over 6 months.. 135 subjects were enrolled in a single-center, double-blind, parallel group, randomized clinical study. Subjects were randomly assigned to one of three treatments: triclosan/copolymer/fluoride dentifrice containing 0.3% triclosan, 2.0% copolymer and 1,450 ppm F as sodium fluoride in a silica base; herbal/bicarbonate dentifrice containing herbal extract and 1,400 ppm F as sodium fluoride in a sodium bicarbonate base; or fluoride dentifrice containing 450 ppm F as sodium fluoride, and 1,000 ppm F as sodium monofluorophosphate. Subjects were instructed to brush their teeth twice daily for 1 minute for 6 months.. After 6 months, subjects assigned to the triclosan/copolymer/fluoride group exhibited statistically significant reductions in gingival index scores and plaque index scores as compared to subjects assigned to the herbal/bicarbonate group by 35.4% and 48.9%, respectively. There were no statistically significant differences in gingival index and plaque index between subjects in the herbal/ bicarbonate group and those in the fluoride group. The triclosan/copolymer/fluoride dentifrice was statistically significantly more effective in reducing gingivitis and dental plaque than the herbal/bicarbonate dentifrice, and this difference in efficacy was clinically meaningful.

Topics: Adolescent; Adult; Aged; Anti-Infective Agents, Local; Dental Plaque; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Fluorides; Follow-Up Studies; Gingivitis; Humans; Male; Middle Aged; Periodontal Index; Phosphates; Phytotherapy; Plant Extracts; Sodium Bicarbonate; Sodium Fluoride; Toothbrushing; Toothpastes; Treatment Outcome; Triclosan; Young Adult

The aim of the study was to evaluate the efficacy of Parodontax® (GlaxoSmith-Kline, Bühl, Germany) on the signs gingival inflammation and the enzyme activity of matrix metalloproteinase-8 (aMMP-8) in the gingival crevicular fluid. After approval by the ethics commission, a total of 50 volunteers participated in the study; group 1 (n = 25, age: 43 ± 12 years) with moderate gingivitis (BOP +) and group 2 (n = 25, age: 29 ± 11 years) with clinically healthy gingival conditions (BOP -). After obtaining anamnestic data, the dental examination included assessment of oral hygiene (Quigley & Hein 1962), gingival inflammation (Saxer & Mühlemann 1975), probing pocket depth and clinical attachment level. Gingival crevicular fluid was collected from both groups. A quantitative assessment of aMMP-8 in the gingival crevicular fluid samples was performed (DentoAnalyzer, Dentognostics GmbH, Jena, Germany). Study participants were instructed to use only Parodontax®. After three weeks, all parameters were measured again. The aMMP-8 values of group 1 were significantly reduced after the use of Parodontax® toothpaste and mouthwash (p < 0.001; baseline median 41.25 ± 38.16 ng/ml, final post-treatment median 7.73 ± 7.58 ng/ml aMMP-8 eluate; group 2: baseline median 3.75 ± 3.16 ng/ml, final post-treatment median 3.73 ± 1.54 ng/ml aMMP-8 eluate). Gingival inflammation and plaque accumulation were reduced. It was shown that Parodontax® was effective in reducing the enzymatic activity of inflammation.

Topics: Adult; Dental Plaque; Female; Gingival Crevicular Fluid; Gingivitis; Humans; Male; Matrix Metalloproteinase 8; Middle Aged; Mouthwashes; Phytotherapy; Plant Extracts; Plant Preparations; Sodium Bicarbonate; Young Adult

The aim of the present study was to investigate the efficacy of an herbal-based mouthrinse in combination with an oral irrigator in reducing gingival inflammation.. A total of 89 patients (45 females, 44 males; mean age 49.1 +/- 1.31 years) were included in this prospective, randomized, double-blind clinical study and allocated to 3 treatment groups: group 1 (n = 34), treated with an oral irrigator with subgingival tips and an herbal-based mouthrinse; group 2 (n = 29), the oral irrigator was applied in combination with a conventional mouthwash; and group 3 (n = 26), treated with the conventional mouthwash without subgingival irrigation. Data collected at baseline and after 4, 8, and 12 weeks included gingival index (GI), sulcus bleeding index (SBI), plaque index (PI), and probing depth (PD).. Over a period of 3 months, GI decreased from 1.80 +/- 0.04 to 1.56 +/- 0.04 in group 1; from 1.79 +/- 0.05 to 1.68 +/- 0.04 in group 2; and remained nearly constant in group 3 (from 1.79 +/- 0.05 to 1.81 +/- 0.04). Differences between the groups were significant (analysis of variance, P < 0.05). SBI values in group 1 were reduced from 2.51 +/- 0.06 to 2.13 +/- 0.06 after 3 months and were significantly lower than in group 2 (P = 0.001) and 3 (P = 0.002), with SBIs of 2.44 +/- 0.06 and 2.42 +/- 0.07, respectively, after 12 weeks. A reduction in PI was noted for all 3 groups throughout the follow-up period, with no statistically significant differences. Probing depths were not reduced significantly in any group.. Subgingival irrigation with an herbal-based mouthrinse led to a significant reduction in both SBI and GI. This regimen can, therefore, be recommended as an adjunctive procedure to reduce gingival inflammation.

Topics: Analysis of Variance; Dental Plaque Index; Double-Blind Method; Female; Follow-Up Studies; Gingival Hemorrhage; Gingivitis; Humans; Male; Middle Aged; Mouthwashes; Oral Hygiene; Periodontal Index; Periodontal Pocket; Plant Extracts; Plants; Prospective Studies; Sodium Bicarbonate; Therapeutic Irrigation

The purpose of this pilot study was to evaluate the effects of an effervescent sodium bicarbonate based oral composition on plaque and gingivitis. Subjects selected for this study presented at screening with moderate plaque and American Academy of Periodontology (AAP) Type I/II periodontal status. At baseline, subjects were allocated to one of two groups by simple randomization; placebo (n=16) and active (n=16). During the study two subjects withdrew due to non-compliance and one because of a death in the family. Data were collected at baseline, day 14, and day 28. The Plaque Index (PI) of Silness and Loe was used to quantify the amount of supragingival plaque surrounding six selected teeth (3,14,8,19,24,30), and the Gingival Index (GI) of Loe and Silness was used to assess bleeding tendencies and visual appearance on the same six teeth. A soft tissue oral assessment was completed at each visit. Subjects were asked to perform study treatment three times a day, after meals, and continue with normal oral hygiene procedures. Subjects were requested to complete a 28-day diary to assess compliance. Data were analyzed using repeated measures analysis of variance. There were no statistically significant differences between the placebo and the active product groups and no statistical significant interaction between product and location within the mouth or visit for either the plaque or gingival scores. Results reveal the product was safe to oral tissues and was well accepted by subjects.

Topics: Adolescent; Adult; Analysis of Variance; Dental Plaque; Dental Plaque Index; Female; Gingivitis; Humans; Male; Mastication; Middle Aged; Mouthwashes; Periodontal Index; Sodium Bicarbonate; Tablets

New evidence suggests a beneficial outcome to chewing a sugarless gum as an added component to a regular, twice-daily toothbrushing regimen. Results of a 4-week study performed on 78 adults with preexisting gingivitis showed a significant reduction of dental plaque and gingivitis when the test group of 39 adults chewed 2 pieces of ARM & HAMMER Dental Care The Baking Soda Gum (AHDC)--a sugar-free chewing gum containing sorbitol, malitol, xylitol, and sodium bicarbonate--for 20 minutes twice a day in conjunction with once-daily toothbrushing for 60 seconds. The control group, also comprised of 39 adults, used breath mints (the study placebo) twice a day in conjunction with the same toothbrushing regimen. There were no statistically significant differences in plaque and gingivitis scores at the baseline examination. Using the Quigley-Hein Plaque Index, the test group experienced a 17% reduction in plaque over 4 weeks, while the control group reduced their plaque amounts by approximately 9% over the same period. Lobene's Mean Gingivitis Index scores were equally significant: a nearly 10% decline for the test group compared to almost 2% for the control group. This article describes the 4-week study and its promising results.

Topics: Adolescent; Adult; Chewing Gum; Dental Plaque; Double-Blind Method; Female; Gingivitis; Humans; Male; Middle Aged; Oral Hygiene Index; Periodontal Index; Sodium Bicarbonate; Sugar Alcohols; Toothbrushing

The purpose of the present study was to determine the ability of a chewing gum containing 5% sodium bicarbonate to remove dental plaque and reduce gingivitis when used as a supplement to daily toothbrushing. The study group consisted of 88 adults with moderate gingivitis. Participants were divided into 4 groups and instructed to chew the study gum 0 (control), 1, 2, or 3 times daily for 1 month in addition to regular daily toothbrushing. Chewing sodium bicarbonate-containing gum significantly (P < .05) reduced plaque after 1 week, with progressively greater reductions occurring after 2 and 4 weeks of gum chewing. No correlation was observed between plaque reduction and the number of times per day that the gum was chewed. By week 4, plaque reduction of approximately 16% was achieved in all groups using the gum as compared with the control group. Reductions in gingivitis were observed in all participants who chewed the gum, and these reductions achieved statistical significance by week 4. Slightly greater improvements in gingivitis were achieved in participants who chewed the gum 2 or 3 times daily as compared with the control group and those who chewed the gum once daily. No adverse effects on the oral tissues were observed in any of the participants for the duration of the study. In conclusion, regular use of a chewing gum containing 5% sodium bicarbonate appears safe and effective for the removal of dental plaque and reduction of gingivitis when used in conjunction with daily toothbrushing.

Topics: Adult; Analysis of Variance; Chewing Gum; Dental Plaque; Female; Gingivitis; Humans; Male; Oral Hygiene Index; Patient Compliance; Sodium Bicarbonate; Toothbrushing

This double-blind parallel-design clinical study compared the efficacy of a stabilized stannous fluoride dentifrice (Crest Plus Gum Care), baking soda and peroxide (NaF) dentifrice (Mentadent), and essential oil mouthrinse (Listerine) to a conventional NaF dentifrice (Crest) for the control of plaque, gingivitis and gingival bleeding over six months. Following an initial baseline examination and stratification, subjects received a complete oral prophylaxis and were distributed assigned test products. Following three and six months, subjects re-visited the clinic for examinations. Evaluations at baseline and at 3 and 6 months included soft tissue status. Löe-Silness gingivitis/gingival bleeding, Silness-Löe plaque and dental stain. Results subsequent to six months of product use were as follows: At six months, the stabilized stannous fluoride dentifrice was observed to produce statistically significant 17.5% reductions in gingivitis and 27.5% reductions in gingival bleeding relative to the NaF dentifrice. The combination of sodium fluoride dentifrice and essential oil mouthrinse produced statistically significant reductions of 7.4% in gingivitis and 10.8% in plaque as compared with the NaF dentifrice. The stabilized stannous fluoride dentifrice produced statistically significant reductions in both gingivitis (10.8%) and gingival bleeding (23.0%) relative to the combination of sodium fluoride dentifrice and essential oil mouthrinse. The baking soda and peroxide (NaF) dentifrice did not provide reductions in gingivitis, plaque or gingival bleeding as compared with the conventional NaF dentifrice. The stabilized stannous fluoride dentifrice provided statistically significant reductions in gingivitis as compared with the baking soda and peroxide dentifrice following six months of use, and both the essential oil mouthrinse and stabilized stannous fluoride dentifrice provided statistically significant reductions in gingivitis as compared with the baking soda and peroxide dentifrice following three months of use. These results support: 1) the efficacy of stabilized stannous fluoride dentifrice and the combination of sodium fluoride dentifrice and essential oil mouthrinse for the prevention of gingivitis; 2) the superior activity of stabilized stannous fluoride dentifrice as compared with a combination of sodium fluoride dentifrice and essential oil mouthrinse for the control of gingivitis and gingival bleeding; and 3) the lack of efficacy for baking soda and pero

Topics: Adult; Analysis of Variance; Dental Plaque; Dental Plaque Index; Dentifrices; Double-Blind Method; Drug Combinations; Female; Gingivitis; Humans; Hydrogen Peroxide; Male; Mouthwashes; Periodontal Index; Salicylates; Sodium Bicarbonate; Sodium Fluoride; Terpenes; Tin Fluorides; Treatment Outcome

This article reports the results of a study that examined the clinical and microbiological changes associated with regular use of baking-soda dentifrices. Two dentifrice formulations were examined in a 6-month longitudinal study of 101 adult subjects with assessments for plaque, gingival inflammation, and stain at baseline and 3 and 6 months during the active phase of the study, and at 3 months after cessation of product use. One dentifrice contained 52% baking soda and 3% sodium percarbonate (Arm & Hammer PeroxiCare) while the other dentifrice contained 65% baking soda (Arm & Hammer Dental Care). Both dentifrices resulted in statistically significant reductions in dental plaque, gingival inflammation, and stain at all time periods compared to baseline. Dental plaque and buccal soft-tissue samples were obtained for microbiological analysis from a 50-subject subset. Microbiological assays, including bacterial culture, phase-contrast microscopy, and immunofluorescence microscopy, confirmed the safety of both formulations. Beneficial alterations in dental plaque bacteria were noted, including significant reductions in the levels of Actinomyces species. The data from this study indicate that dentifrices containing high levels of baking soda are clinically effective and microbiologically safe.

Topics: Adolescent; Adult; Aged; Bacteria; Carbonates; Colony Count, Microbial; Consumer Product Safety; Dental Plaque; Dentifrices; Drug Combinations; Ecosystem; Female; Gingivitis; Humans; Hydrogen Peroxide; Longitudinal Studies; Male; Microscopy, Fluorescence; Middle Aged; Sodium Bicarbonate; Tooth Discoloration; Toothpastes

Oral malodor, also known as bad breath or halitosis, is an extremely common problem. Bad breath can arise from many sources in the body, but most frequently is produced in the mouth by the action of gram-negative anaerobic bacteria on sulfur-containing proteinaceous substrates in the saliva, such as debris and plaque. The primary molecules responsible for oral malodor are volatile sulfur compounds (VSC), such as hydrogen sulfide and methylmercaptan. Increased malodor production is related to greater bacterial numbers, reducing conditions, availability of protein substrates, and a pH above neutral. Bad breath is more common in the elderly, as well as those with unhygienic mouths, gingivitis, and periodontitis, but bad breath can also be found in some individuals who are periodontally healthy. The major source of oral malodor is the tongue. Approaches to controlling malodor have included masking, oral hygiene, antibacterial agents, conversion of VSC to nonodorous forms, oxidizing agents, and traditional approaches, including the use of baking soda. Results of controlled double-blind crossover studies, using both organoleptic (sensory) and gas chromatographic analysis of mouth air VSC, indicate that two dentifrices with high baking-soda concentrations, Arm & Hammer Dental Care and Arm & Hammer PeroxiCare, reduce oral malodor.

Topics: Adult; Aged; Analysis of Variance; Anti-Infective Agents, Local; Chromatography, Gas; Cross-Over Studies; Dental Deposits; Dental Plaque; Dentifrices; Double-Blind Method; Gingivitis; Gram-Negative Anaerobic Bacteria; Halitosis; Humans; Hydrogen Sulfide; Hydrogen-Ion Concentration; Male; Middle Aged; Oral Hygiene; Oxidants; Periodontitis; Saliva; Smell; Sodium Bicarbonate; Sulfhydryl Compounds; Sulfur Compounds; Time Factors; Tongue

This article reports the results of a study that examined the clinical and microbiological changes associated with regular use of baking-soda dentifrices. Two dentifrice formulations were examined in a 6-month longitudinal study of 101 adult subjects with assessments for plaque, gingival inflammation, and stain at baseline and 3 and 6 months during the active phase of the study, and at 3 months after cessation of product use. One dentifrice contained 52% baking soda and 3% sodium percarbonate (Arm & Hammer PeroxiCare) while the other dentifrice contained 65% baking soda (Arm & Hammer Dental Care). Both dentifrices resulted in statistically significant reductions in dental plaque, gingival inflammation, and stain at all time periods compared to baseline. Dental plaque and buccal soft-tissue samples were obtained for microbiological analysis from a 50-subject subset. Microbiological assays, including bacterial culture, phase-contrast microscopy, and immunofluorescence microscopy, confirmed the safety of both formulations. Beneficial alterations in dental plaque bacteria were noted, including significant reductions in the levels of Actinomyces species. The data from this study indicate that dentifrices containing high levels of baking soda are clinically effective and microbiologically safe.

Topics: Actinomyces; Adolescent; Adult; Aged; Carbonates; Dental Plaque; Dental Plaque Index; Dentifrices; Female; Follow-Up Studies; Fusobacterium nucleatum; Gingivitis; Humans; Longitudinal Studies; Male; Microscopy, Fluorescence; Microscopy, Phase-Contrast; Middle Aged; Periodontal Index; Porphyromonas gingivalis; Prevotella intermedia; Safety; Sodium Bicarbonate; Streptococcus mutans; Tooth Discoloration

A double-blind controlled clinical trial with parallel groups was designed to investigate the effectiveness of a herbal-based toothpaste in the control of plaque and gingivitis as compared with a conventional dentifrice. 70 subjects with gingivitis completed the 6-week study. All participants had at least 20 natural teeth with no probing depths greater than 3 mm and a plaque index of 2 or more at baseline. At baseline, both groups were balanced for the parameters measured: plaque index, plaque vitality, gingival index, bleeding on probing and gingival crevicular fluid flow. At the end of the trial, there were reductions within both groups, however, there were no significant differences between the groups. It was concluded that the herbal based toothpaste was as effective as the conventionally formulated dentifrice in the control of plaque and gingivitis.

Topics: Adolescent; Adult; Aged; Dental Plaque; Dental Plaque Index; Dentifrices; Double-Blind Method; Female; Gingival Crevicular Fluid; Gingival Hemorrhage; Gingival Pocket; Gingivitis; Humans; Magnoliopsida; Male; Middle Aged; Periodontal Index; Plant Extracts; Plants, Medicinal; Sodium Bicarbonate; Toothpastes

To investigate the effect of a baking soda-hydrogen peroxide (0.75%) dentifrice on wound healing, plaque formation, gingival inflammation, patient comfort, probing depth, and clinical attachment level following gingival flap surgery.. A randomized, double-blind crossover study involving 25 patients requiring bilateral maxillary gingival flap surgery was completed. The effects of twice daily brushing with a baking soda-hydrogen peroxide dentifrice (Mentadent) or a placebo dentifrice (Crest) were observed over a 28-day post-surgical period. Gingival Index (GI), plaque index (PI), probing depth (PD), clinical attachment level (CAL) and gingival bleeding index (BI) were recorded pre-surgically and at day 28 for each surgical sextant. At days 7 and 14, soft tissue appearance/wound healing (STA) was assessed based on color and edema, PIs were determined and patient comfort was ascertained by report.. Post-surgical wound healing was statistically significantly improved at day 7 with the trend continuing to day 14 when Mentadent dentifrice was used as compared to Crest dentifrice. However, there was no statistical difference in the PI values between the test and control dentifrice throughout the study. Use of Mentadent may be an effective aid in the early phase of healing following gingival flap surgery.

Topics: Adult; Aged; Anti-Infective Agents, Local; Cross-Over Studies; Dental Plaque; Dental Plaque Index; Dentifrices; Double-Blind Method; Edema; Female; Gingivitis; Gingivoplasty; Humans; Hydrogen Peroxide; Male; Middle Aged; Pain, Postoperative; Periodontal Index; Postoperative Period; Sodium Bicarbonate; Surgical Flaps; Wound Healing

In this study on 60 adult subjects, the effective of Parodontax, a dentifrice containing herbal ingredients and sodium bicarbonate abrasive, was compared to a non-marketed new toothpaste containing herbal ingredients and calcium hydrogen phosphate as the abrasive. Plaque, gingivitis and gingival bleeding parameters were scored. The periodontal probe bleeding index of Ainamo and Bay was modified to score slight and moderate bleeding. In this first four-week period all subjects used the new toothpaste. After this period the new toothpaste produced a significant decrease (p<0.01) in gingivitis and bleeding on probing, but no effect on plaque was observed. During the second period of eight weeks the subjects were randomly divided into two groups, one using Parodontax and the other group continuing with the new toothpaste. The study design was a double-blind procedure. At the end of the 12-week study period the plaque index showed no changes in both groups. The gingivitis and bleeding indices decreased significantly (p<0.001) by 40% in both groups compared to the baseline examination.

Topics: Adult; Analysis of Variance; Dental Plaque; Dental Plaque Index; Double-Blind Method; Gingivitis; Humans; Periodontal Index; Plant Extracts; Sodium Bicarbonate; Toothpastes

In this study on twenty-two adult subjects, the effectiveness of Parodontax dentifrice was compared to a control dentifrice on gingival bleeding parameters. The periodontal probe bleeding index of Ainamo and Bay, modified to evaluate slight and moderate bleeding, was used to evaluate efficacy. There was no significant difference between the two groups at baseline. After four weeks, Parodontax dentifrice produced a significant decrease (p < 0.01) in bleeding on probing compared both to baseline (p < 0.01) and to the control group (p < 0.05), and an increase (p < 0.05) in the number of sites with no bleeding compared to the control dentifrice. The control had no significant decrease in bleeding on probing from baseline to four weeks. The number of bleeding sites were significantly reduced in the Parodontax dentifrice group from baseline to week four (p < 0.001), and there was no significant statistical change in the number of bleeding sites for the control group. The Parodontax dentifrice group bleeding sites at four weeks were significantly lower than the control group (p < 0.05).

Topics: Adult; Analysis of Variance; Dentifrices; Follow-Up Studies; Gingival Hemorrhage; Gingivitis; Humans; Periodontal Index; Plant Extracts; Plants, Medicinal; Sodium Bicarbonate

A 12-month clinical trial was conducted to compare the effectiveness of a pre-brushing rinse (PBR) in plaque removal with that of water. Four groups participated in the study; group 1 (test group) rinsed with PBR before brushing; group 2 rinsed with plain tap water; group 3 brushed only; and group 4 rinsed with sterile water (same color as the PBR). Pre-brushing and post-brushing plaque scores were recorded at baseline, 3 months, 6 months, 9 months (Ramjford surfaces) and 12 months for groups 1, 2, and 3 and at baseline, 3 months and 6 months for group 4. Pre-brushing minus post-brushing plaque scores (decrements) were significantly higher in the PBR group at baseline, and 6, 9, and 12 months. Using a single criterion (gingival bleeding index) there were no differences between the 4 groups at any of the 5 assessments, hence, the clinical significance of the higher plaque removal scores in the PBR group remains in doubt.

Topics: Adolescent; Adult; Aged; Analysis of Variance; Benzoates; Benzoic Acid; Dental Plaque; Ethanol; Gingivitis; Humans; Middle Aged; Mouthwashes; Sodium Bicarbonate; Sodium Dodecyl Sulfate; Toothbrushing; Water

The objective of this study was to evaluate the effect of a sodium benzoate-sodium bicarbonate (SBSB) compound on dental plaque formation and developing gingivitis. Eighteen subjects were given a prophylaxis and instruction in oral hygiene to establish plaque-free conditions and gingival health for the study baseline. They were randomly divided into three groups. Each participant was instructed to rinse twice daily with either a 0.15% chlorhexidine digluconate solution, the SBSB compound, or a placebo solution for 21 days. They refrained from all other oral hygiene procedures during this period. Plaque, gingival, and stain indices were scored at baseline and at days 7, 14, and 21 during the rinsing protocol. A significant increase in plaque accumulation was observed for the SBSB compound and placebo groups in days 7 through 21. No increase in plaque accumulation was observed in the chlorhexidine group. An increase in gingival inflammation was observed in all groups, with no significant differences between groups. Significant increases in gingival bleeding occurrence compared to baseline were found in the chlorhexidine group by day 21, in the SBSB compound group by day 7, and in the placebo group by day 14. The present study did not disclose any plaque or gingivitis inhibiting effects of the SBSB compound.

Topics: Adult; Analysis of Variance; Benzoates; Benzoic Acid; Chlorhexidine; Dental Plaque; Double-Blind Method; Female; Gingivitis; Humans; Male; Sodium Bicarbonate

Topics: Bicarbonates; Child; Clinical Trials as Topic; Dentifrices; Gingivitis; Humans; Orthodontic Appliances; Phytotherapy; Random Allocation; Sodium; Sodium Bicarbonate; Toothpastes

Topics: Adult; Aged; Bicarbonates; Dentifrices; Double-Blind Method; Female; Gingivitis; Humans; Male; Middle Aged; Multicenter Studies as Topic; Periodontitis; Phytotherapy; Sodium; Sodium Bicarbonate; Toothpastes

The objective of this study was to investigate the antigingivitis and antiplaque treatment effect of a toothpaste containing 67% w/w sodium bicarbonate, at the individual tooth site, tooth region and whole mouth (overall) level, by way of a pooled analysis of data from similarly designed clinical trials.. Six randomized controlled GSKCH clinical trials, 12-24 weeks in duration, were selected based on pre-specified criteria which included access to patient level data, pre-treatment dental prophylaxis, >20 bleeding sites and mild-moderate gingivitis at screening and use of 67% sodium bicarbonate toothpaste and non-sodium bicarbonate (regular) toothpaste (negative control) for ≥4 weeks. Efficacy outcomes comprised plaque index (TPI), modified gingival index (MGI) and gingival bleeding (bleeding index (BI), number of bleeding sites (BS)). Treatment comparisons were made using ANCOVA for whole mouth (overall) scores and by tooth site region (facial overall, lingual overall; margin/body overall, facial margin/body, lingual margin/body; papillae/interproximal overall, facial papillae/interproximal, lingual papillae/interproximal). Pooled data for BI, MGI, and TPI at individual tooth sites was plotted as a mouthmap to summarize treatment response (change from baseline) by tooth site, at the 24-week timepoint.. For all measures, whole mouth and for all tooth regions at all post-treatment timepoints, significant (p < 0.001) differences in favour of the 67% sodium bicarbonate toothpaste compared with control were observed. At the 24-week timepoint, facial regions demonstrated greater improvements than lingual regions, with the greatest between treatment improvement seen for the facial-papillae regions for bleeding (BS/BI), facial-margin regions for MGI and facial-body regions for TPI. All individual tooth sites demonstrated numerically greater reductions from baseline for the 67% sodium bicarbonate toothpaste than the control toothpaste following 24 weeks use, with the greatest improvements (change from baseline) seen for posterior and papillae tooth sites for bleeding, margin tooth sites for MGI and body tooth sites for TPI.. This pooled analysis of patient level-data, limited to GSKCH long-term gingivitis clinical studies, demonstrates that twice daily use of a 67% sodium bicarbonate toothpaste effectively removes plaque from all tooth sites, and results in clinically significant improvements in measures of gingival health, overall and for all the tooth regions investigated, compared with a non-sodium bicarbonate (regular) toothpaste following 24 weeks twice daily use.

Topics: Bicarbonates; Dental Plaque Index; Gingivitis; Humans; Sodium Bicarbonate; Toothbrushing; Toothpastes; Treatment Outcome

Was to evaluate the clinical efficacy of parodontax Comprehensive Protection (GlaxoSmithKline, London, UK) toothpaste in the complex therapy of chronic gingivitis.. The study involved 119 volunteers; group 1 (. After 4 weeks, SBI scores in group 1 were 63% lower than at baseline, and in group 2 - by 30%. PMA values at 4 weeks in group 1 were 58% and in group 2 30% lower, compared to baseline levels. The results of the analysis of the OHI-S index showed a statistically significant decrease in group 1 by 75%, while in group 2 by only 8% from the initial values. The difference in all index values between groups at 4 weeks of the study was statistically significant (. The use of parodontax Comprehensive Protection Toothpaste (GlaxoSmithKline, London, UK) has been shown to reduce the clinical signs of biofilm-associated gingivitis and effectively maintain optimal oral hygiene in patients.. Оценка клинической эффективности применения зубной пасты parodontax Комплексная Защита (GlaxoSmithKline, Великобритания) в комплексной терапии хронического гингивита.. В исследовании приняли участие 119 добровольцев: 1-я группа (. Через 4 нед показатели индекса SBI в 1-й группе были ниже на 63% по сравнению с исходным уровнем, а во 2-й группе — на 30%. Показатели PMA через 4 нед в 1-й группе были ниже на 58%, а во 2-й группе — на 30% по сравнению с исходными уровнями (. Разница значений всех индексов между группами на 4-й неделе исследования явилась статистически значимой (

Topics: Adolescent; Adult; Dental Plaque; Dental Plaque Index; Gingivitis; Humans; Sodium Bicarbonate; Toothpastes; Young Adult

Many of the parameters used in clinical dental research involve the assessment of a condition at each of a number of sites within the mouth. Traditionally, such measurements are averaged over all sites within the mouth (or over all sites of a specified type) for each study participant before statistical analysis. However, a consideration of the original, site-wise scores may provide some additional insights into the performance of therapeutic modalities that might not be made evident through an application of the traditional, means-based approach. A method based on the calculation of site-wise odds ratios of certain types of baseline-to-final examination score transitions was applied to the modified gingival index data from two clinical studies performed to investigate the effect of the daily chewing of a commercially available chewing gum relative to a mint control. A graphical display of these site-specific findings was prepared, which indicated that the chewing gum regimen tended to be associated with a higher frequency of occurrence of favorable score transitions than was the mint control at several measurement sites throughout the mouth.

Topics: Chewing Gum; Computer Graphics; Confidence Intervals; Gingivitis; Humans; Odds Ratio; Periodontal Index; Sodium Bicarbonate

Topics: Bicarbonates; Calcium Phosphates; Gingivitis; Humans; Sodium; Sodium Bicarbonate; Toothpastes

Clinical, histologic and scanning electron microscopic study of the use of the Prophy-Jet. The Prophy-Jet (Cavitron-International) is used for the removal of gross stain and heavy plaque. In this study the plaque and stain removal capacities have been investigated in patients with a healthy and inflamed gingiva. The influence of the spray of cleaning powder (sodiumbicarbonate) on the gingiva has been studied in gingival biopsies of Beagle dog. With the use of a scanning electron microscope the dentine and cementum have been investigated after spraying during 30 seconds to 2 minutes. The clinical results show that the plaque and the stain are removed easily and significantly except for the deep interproximal regions where the handpiece tip cannot be used in a correct angulation to the tooth surface. All patients showed gingival desquamation which could last up to 3 days. After treatment several patients suffered from aphthous ulcers. The gingiva of the Prophy-Jet treated areas in the Beagle dog showed severe epithelial desquamation, even of the papillary connective tissue, which in certain areas, can lead to necrosis. A spray lasting for 30 seconds removed approximately 10 micrograms of dentine or cementum. From these results it can be concluded that the negative aspects of the use of the Prophy-Jet are very important. It should therefore be used with caution.

Topics: Animals; Bicarbonates; Calcium Phosphates; Dental Plaque; Dental Prophylaxis; Dogs; Gingiva; Gingivitis; Humans; Microscopy, Electron, Scanning; Pressure; Sodium Bicarbonate; Tooth Discoloration