sodium-bicarbonate and Failure-to-Thrive

Topics: Acidosis, Renal Tubular; Child; Child, Preschool; Citrates; Citric Acid; Failure to Thrive; Female; Follow-Up Studies; Growth Disorders; Humans; Infant; Sodium Bicarbonate; Sodium Citrate

In this report, we present a case of a child with distal renal tubular acidosis, severe failure to thrive and profound rickets, who was only 7.8 Kg when presented at 6 years of age. His response to treatment and his follow-up for four years is discussed. Although failure to thrive is a common finding in renal tubular acidosis but the physical and x-ray findings in our case were unique.

Topics: Acidosis, Renal Tubular; Child; Drug Therapy, Combination; Failure to Thrive; Follow-Up Studies; Humans; Male; Potassium Chloride; Rickets; Severity of Illness Index; Sodium Bicarbonate; Vitamin D; Vitamins

A patient with deficient activity of cytochrome c oxidase in muscle presented at 1 year of age with extreme failure to thrive. He was found to have dicarboxylic aciduria, renal tubular acidosis, and deficiency of carnitine. Treatment with sodium bicarbonate, riboflavin, and carnitine led to considerable improvement in growth and a significant reduction in the dicarboxylic aciduria.

Topics: Acidosis, Renal Tubular; Amino Acids, Dicarboxylic; Bicarbonates; Carnitine; Cytochrome-c Oxidase Deficiency; Failure to Thrive; Humans; Infant; Male; Muscles; Riboflavin; Sodium; Sodium Bicarbonate

Topics: Acid-Base Equilibrium; Acidosis; Bicarbonates; Failure to Thrive; Humans; Infant, Newborn; Infant, Premature, Diseases; Sodium; Sodium Bicarbonate; Water-Electrolyte Balance