sodium-bicarbonate and Erectile-Dysfunction

A prospective, randomized, double-blind study was done to determine whether alkalization of prostaglandin E1 decreases pain associated with intracavernous injection.. Ten subjects with a history of pain following at least 70% of injections of prostaglandin E1 received 2 injections of prostaglandin E1, 1 with and 1 without sodium bicarbonate. Patients reported the duration and intensity of pain following each injection.. Comparing injections of prostaglandin E1 with and without bicarbonate, there were no significant differences in number of subjects reporting pain, or duration and intensity of pain.. Addition of sodium bicarbonate does not alleviate penile pain associated with injection of prostaglandin E1.

Topics: Adolescent; Adult; Aged; Alprostadil; Double-Blind Method; Drug Therapy, Combination; Erectile Dysfunction; Humans; Injections; Male; Middle Aged; Pain; Penis; Prospective Studies; Sodium Bicarbonate; Vasodilator Agents

In an attempt to determine whether penile pain associated with intracorporeal injections could be due to the acidity of the medication, we performed a randomized study comparing the incidence of penile pain following intracorporeal injections with or without the addition of sodium bicarbonate to the intracorporeal medications. A total of 38 consecutive patients who presented to our clinic with impotence received 0.2 ml. of a combination of 3 drugs: 6 mg. papaverine, 100 micrograms. phentolamine and 10 micrograms. prostaglandin E1 with (pH 7.05) or without (pH 4.17) the addition of sodium bicarbonate (0.03 mEq.). Of the 19 patients without sodium bicarbonate added to the medication 11 (58%) complained of penile pain due to the medication, while only 1 of the 19 men (5%) who received sodium bicarbonate complained of penile pain. From these data we conclude that the penile pain following intracorporeal injections is most likely due to the acidity of the medication, which can be overcome by elevating the pH to a neutral level.

Topics: Adult; Aged; Alprostadil; Bicarbonates; Double-Blind Method; Drug Combinations; Erectile Dysfunction; Humans; Incidence; Injections; Male; Middle Aged; Pain; Papaverine; Penile Erection; Penis; Phentolamine; Sodium; Sodium Bicarbonate

Prolonged erections, priapism, secondary to pharmacologic stimulation are usually treated by drainage of the corporeal bodies and irrigation with a sympathomimetic. To study the efficacy of oral medical therapy in the treatment of priapism, 75 patients with pharmacologically induced (prostaglandin E1) prolonged erections were randomized to receive terbutaline, pseudoephedrine, or placebo. Detumescence occurred in 36 percent, 28 percent, and 12 percent, respectively. Terbutaline was significantly better than placebo (p < 0.05) in achieving detumescence. The results of this study suggest that oral terbutaline should be considered in the initial management of pharmacologically induced prolonged erections.

Topics: Alprostadil; Bicarbonates; Ephedrine; Erectile Dysfunction; Humans; Male; Priapism; Sodium; Sodium Bicarbonate; Terbutaline