sodium-bicarbonate and Atrial-Flutter

Poisoning with flecainide acetate is rare and associated with a high mortality. This usually occurs after massive ingestion but can also be observed during therapeutic overdose in patients with renal failure or with amiodarone therapy. The prognostic depends on the haemodynamic and rhythmic effects of the overdose one sign of which is widening of the QRS complexes. Major sodium bicarbonate or lactate infusion is the generally prescribed treatment. The authors report one case of a patient with renal failure on amiodarone who survived a severe flecainide acetate overdose.

Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Flutter; Biological Availability; Calcium Gluconate; Charcoal; Combined Modality Therapy; Consciousness Disorders; Diabetic Nephropathies; Drug Interactions; Drug Therapy, Combination; Flecainide; Heart Block; Hemofiltration; Humans; Hypertension; Hypotension; Intestinal Pseudo-Obstruction; Kidney Failure, Chronic; Male; Poisoning; Pulmonary Edema; Renal Dialysis; Respiration, Artificial; Sodium Bicarbonate; Sodium Channel Blockers; Uremia

Topics: Aged; Atrial Flutter; Diagnosis, Differential; Dose-Response Relationship, Drug; Female; Flecainide; Humans; Renal Insufficiency; Risk Adjustment; Risk Factors; Sodium Bicarbonate; Tachycardia, Supraventricular; Tachycardia, Ventricular; Voltage-Gated Sodium Channel Blockers