sodium-bicarbonate and Asthma

Topics: Adrenal Cortex Hormones; Asthma; Bicarbonates; Child; Humans; Infant; Infusions, Parenteral; Isoproterenol; Oxygen Inhalation Therapy; Respiration, Artificial; Sodium Bicarbonate; Status Asthmaticus; Sympathomimetics; Theophylline

Topics: Acidosis, Respiratory; Acute Disease; Adult; Asthma; Bicarbonates; Child; Dehydration; Epinephrine; Heart Rate; Humans; Hydrocortisone; Isoproterenol; Methylprednisolone; Oxygen Inhalation Therapy; Patient Admission; Risk; Sodium Bicarbonate; Theophylline; United States; Ventilators, Mechanical

Chlorine is one of the most common substances involved in toxic inhalation. As with all irritant gases, the airway injuries caused by chlorine gas may result in clinical manifestations similar to those of asthma. In this study, we investigated the effect of nebulized sodium bicarbonate (NSB) on the treatment and quality of life (QoL) of victims exposed to chlorine gas. Forty-four consecutive patients with reactive airways dysfunction syndrome (RADS) due to chlorine inhalation (40 females and 4 males, age range 17-56 yr) were included in this study. Patients were placed in control and treatment groups in a sequential odd-even fashion based on their order of presentation. Treatment of all patients included corticosteroids and nebulized short-acting beta2-agonists. Then the control group (n = 22) received nebulized placebo (NP), and the NSB group (n = 22) received NSB treatment (4 cm3 of 4.20% sodium bicarbonate solution). A quality of life (QoL) questionnaire and pulmonary function tests (PFTs) were performed before and after treatments in both groups. The most common symptoms were dyspnea (82%) and chest tightness (82%). Baseline characteristics of both groups were similar. Compared to the placebo group, the NSB group had significantly higher FEV1 values at 120 and 240 min (p < .05). Significantly more improvement in QoL questionnaire scores occurred in the NSB group compared to the NP group (p < .001). Thus, NSB is a clinically useful treatment, as tested by PFTs and QoL questionnaire, for patients with RADS caused by exposure to chlorine gas.

Topics: Adolescent; Adult; Air Pollutants; Albuterol; Asthma; Chlorine; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Inhalation Exposure; Lung; Male; Middle Aged; Nebulizers and Vaporizers; Prednisolone; Quality of Life; Respiratory Function Tests; Sodium Bicarbonate; Surveys and Questionnaires; Treatment Outcome

We compared the effects of an acaricide, benzyl benzoate, with the effects of baking soda control applied to bedroom and living room carpets on house dust mite allergen levels, lung function, and medication use in 12 adult patients with asthma for 12 months.. This was a randomized, double-blind, placebo-controlled study. Patients were enrolled from the allergy clinic of a large tertiary care center in a metropolitan area. All patients had positive dust mite puncture test results. Six patients used benzyl benzoate, and six used baking soda. Other aggressive mite control measures were implemented uniformly in each group. Subjects were to make two carpet applications, at baseline and at 6 months according to the manufacturer's recommendations. Dust samples were collected in bedroom and living room carpets at 0, 3, 6, 9, and 12 months; and quantities of Der p I and Der f I allergens were determined. Spirometry was done every 3 months, and peak flow rates were recorded for 10 days after each dust sampling.. There were no significant differences in mean allergen levels between the two groups over time at either site. There were no significant changes in lung function or medication use for either group.. Benzyl benzoate powder applications may not be effective when done according to manufacturer's instructions. Further studies are necessary to test effectiveness when applied more frequently and for longer periods.

Topics: Adult; Aged; Allergens; Animals; Asthma; Benzoates; Chi-Square Distribution; Double-Blind Method; Dust; Female; Floors and Floorcoverings; Humans; Insecticides; Male; Middle Aged; Mites; Respiratory Hypersensitivity; Sodium Bicarbonate

Acid hydrolysis of components from the diet in the stomach require the presence of an acid and a hydrolysing agent. The acid involved is hydrochloric acid. The present mechanism of hydrochloric acid production in the stomach is demonstrated to be incompatible with measured intracellular or intercellular concentrations of the relevant ions. An alternative set of chemical reactions whereby hydrochloric acid is formed in the stomach is presented. The hydrolysing agent is identified and a mechanism of transfer of chemical compounds into the metabolism is described. The hypothesis demonstrates that some of chemical compounds produced in the stomach can induce conditions such as asthma and that the conditions of osteoporosis and hemochromatosis can be linked to the function of the stomach. Possible treatments for these and other conditions such as stomach acidity and anaemia are proposed.

Topics: Adult; Ammonia; Antacids; Asthma; Bicarbonates; Calcium Chloride; Calcium Phosphates; Chlorides; Digestion; Ferric Compounds; Ferrous Compounds; Gastric Acid; Gastric Juice; Gastric Mucosa; Gastritis; Gastrointestinal Contents; Helicobacter Infections; Helicobacter pylori; Hemochromatosis; Humans; Hydrolysis; Ion Transport; Metabolic Diseases; Models, Biological; Models, Chemical; Nitrous Oxide; Osteoporosis; Parietal Cells, Gastric; Sodium Bicarbonate; Stomach

Topics: Acid-Base Imbalance; Acidosis, Respiratory; Asthma; Buffers; Humans; Sodium Bicarbonate

This is a case report of a 15-year-old asthmatic girl who was admitted with a severe acute attack of bronchial asthma who eventually recovered, possibly with the help of sodium bicarbonate solution nebulization.

Topics: Acute Disease; Adolescent; Asthma; Bronchoconstriction; Bronchodilator Agents; Female; Humans; Nebulizers and Vaporizers; Sodium Bicarbonate

Topics: Adult; Asthma; Carbon Dioxide; Female; Humans; Hypercapnia; Respiration, Artificial; Sodium Bicarbonate

Topics: Acute Disease; Antacids; Asthma; Citrates; Citric Acid; Drug Combinations; Female; Humans; Middle Aged; Sodium Bicarbonate

Topics: Adolescent; Adult; Asthma; Bicarbonates; Bronchoconstriction; Female; Humans; Male; Middle Aged; Nebulizers and Vaporizers; Peak Expiratory Flow Rate; Sodium; Sodium Bicarbonate

Respiratory acidosis of severe acute asthma is a severity factor. In this paper the treatment of associated metabolic acidosis is discussed. Among 34 consecutive episodes of severe acute asthma with acidosis (pH < 7.35) treated with continuous adrenaline perfusion, theophylline and hydrocortisone hemisuccinate, respiratory acidosis was observed in 12, metabolic acidosis in 2 and mixed respiratory and metabolic acidosis in 20. The association of hypercapnic acidosis with hypochloraemic acidosis reflected a time of installation longer than when respiratory acidosis only was present (p < 0.05). Among the 22 patients who had metabolic acidosis on admission, 14 were treated with 168 +/- 82 mmol of sodium bicarbonate, the remaining 8 patients being untreated and acting as controls. The rapidity with which pH was corrected was the same in the treated and untreated groups (9.1 +/- 5.5 hours vs 6.7 +/- 3.7 hours), whereas dyspnoea (respiratory rate < 18/min) was more rapidly corrected in the treated group that in controls (11.6 +/- 5.7 hours vs 5.9 +/- 5.9 hours; p < 0.05). It is concluded that in more than 50% of the cases respiratory acidosis of severe acute asthma is associated with a metabolic acidosis. Correcting this metabolic acidosis with sodium bicarbonate results in improvement of respiration, perhaps by facilitating the action of bronchodilator catecholamines.

Topics: Acidosis; Acidosis, Respiratory; Acute Disease; Asthma; Bicarbonates; Bronchodilator Agents; Humans; Hydrogen-Ion Concentration; Sodium; Sodium Bicarbonate

A patient with a history of previous mechanical ventilation for asthma was hospitalized with acute, severe asthma; metabolic acidosis; and hyperlactatemia. In addition to standard therapy, she was successfully treated with face-mask CPAP and IV sodium bicarbonate infusion. This therapy may help prevent mechanical ventilation in some patients with acute, severe asthma and lactic acidosis.

Topics: Acidosis, Lactic; Adult; Asthma; Bicarbonates; Female; Humans; Infusions, Intravenous; Positive-Pressure Respiration; Sodium; Sodium Bicarbonate

Topics: Adult; Asthma; Bicarbonates; Female; Humans; Male; Respiratory Insufficiency; Sodium; Sodium Bicarbonate; Ventilators, Mechanical

Topics: Anesthetics; Asthma; Bicarbonates; Combined Modality Therapy; Humans; Respiration, Artificial; Sodium Bicarbonate

Topics: Acid-Base Equilibrium; Airway Obstruction; Asthma; Bicarbonates; Drug Therapy; Geriatrics; Humans; Injections; Injections, Intravenous; Sodium Bicarbonate; Water-Electrolyte Balance