sodium-bicarbonate and Anaphylaxis

We present a case of wheat-dependent exercise-induced anaphylaxis, in which pretreatment with sodium bicarbonate inhibited reappearance of anaphylactic symptoms following wheat and exercise provocation. Decrease in blood pH relative to elevation in plasma histamine levels was also inhibited. These results suggest possible efficacy of pretreatment with sodium bicarbonate as a preventive measure in patients with exercise-induced anaphylaxis.

Topics: Adult; Anaphylaxis; Bicarbonates; Exercise; Histamine; Humans; Male; Sodium; Sodium Bicarbonate; Time Factors; Triticum

Topics: Anaphylaxis; Bicarbonates; Humans; Physical Exertion; Sodium; Sodium Bicarbonate

When vascular access is delayed or unreliable in emergency situations, an endotracheal tube provides a rapid and reliable route for administration of medication. Epinephrine, lidocaine, and atropine have shown clinical efficacy when given by the endotracheal route. There is evidence that other medications including naloxone and diazepam may also be suitable for endotracheal use, but clear-cut recommendations await further studies of pharmacokinetics and toxicity.

Topics: Adult; Anaphylaxis; Anti-Arrhythmia Agents; Atropine; Bicarbonates; Diazepam; Emergencies; Epinephrine; Heart Arrest; Humans; Intubation, Intratracheal; Lidocaine; Naloxone; Pharmaceutical Preparations; Sodium Bicarbonate