sodium-bicarbonate has been researched along with Acquired-Immunodeficiency-Syndrome* in 2 studies
1 trial(s) available for sodium-bicarbonate and Acquired-Immunodeficiency-Syndrome
| Article | Year |
|---|---|
Intralesional vinblastine for cutaneous Kaposi's sarcoma associated with acquired immunodeficiency syndrome. A clinical trial to evaluate efficacy and discomfort associated with infection.
Intralesional vinblastine has been used to treat Kaposi's sarcoma associated with acquired immunodeficiency syndrome (AIDS-KS). Injections are painful and anticipated response rates are not well documented.. Eleven homosexual men were studied to evaluate the efficacy and pain associated with intralesional vinblastine with or without 1% bicarbonate buffered lidocaine (BBL).. Six lesions on each patient were selected and treated with either vinblastine, vinblastine mixed with BBL, or vinblastine 5 minutes after BBL injection. Control lesions received BBL, saline, or no treatment. Patients recorded injection pain on a visual analog scale.. There was a complete or partial clinical response in 88% of vinblastine-treated lesions. Pain scores for BBL, vinblastine, and the mixture of BBL and vinblastine were not statistically different.. Intralesional vinblastine is effective therapy for AIDS-KS. Local anesthesia does not reduce efficacy of treatment, or reduce the pain experienced by the patient. Topics: Acquired Immunodeficiency Syndrome; Adult; Bicarbonates; Buffers; Humans; Injections, Intralesional; Lidocaine; Male; Pain; Sarcoma, Kaposi; Skin Neoplasms; Sodium; Sodium Bicarbonate; Vinblastine | 1993 |
1 other study(ies) available for sodium-bicarbonate and Acquired-Immunodeficiency-Syndrome
| Article | Year |
|---|---|
A case of lactic acidosis caused by stavudine in an AIDS patient.
Nucleoside reverse transcriptase inhibitors (NRTIs), which are used for the treatment of human immunodeficiency virus (HIV) infection have been associated with a wide spectrum of clinical manifestations, including hepatic steatosis, lipodystrophy, myopathy, and lactic acidosis. Such adverse effects are postulated to result from the inhibition of mitochondrial DNA gamma polymerase, which causes the depletion of mitochondrial DNA and eventual the disruption of oxidative phosphorylation. Although cases of severe decompensated lactic acidosis are rare, this syndrome is associated with a high mortality rate. We report upon the first Korean case, of severe lactic acidosis in an acquired immunodeficiency syndrome (AIDS) patient receiving stavudine, an anti-HIV drug. Topics: Acidosis, Lactic; Acquired Immunodeficiency Syndrome; Adult; Anti-HIV Agents; Female; Humans; Sodium Bicarbonate; Stavudine | 2004 |