sodium-artesunate and Prostatic-Neoplasms

sodium-artesunate has been researched along with Prostatic-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for sodium-artesunate and Prostatic-Neoplasms

ArticleYear
Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    In only four chemical steps from naturally occurring artemisinin (1), trioxane dimers 6 and 7 were prepared on a multigram scale in overall 32-44% yields. In mice, both isonicotinate N-oxide dimer 6 and isobutyric acid dimer 7 were considerably more antimalarially efficacious than clinically used sodium artesunate (2) via both oral and intravenous administration. In the transgenic adenocarcinoma of mouse prostate model, some of the trioxane dimers had potent anticancer activity.

    Topics: Adenocarcinoma; Administration, Oral; Animals; Antimalarials; Antineoplastic Agents; Artemisinins; Cell Line, Tumor; Dimerization; Drug Resistance; Drug Screening Assays, Antitumor; Flow Cytometry; Injections, Intravenous; Male; Mice; Plasmodium falciparum; Prostatic Neoplasms; Structure-Activity Relationship

2004