sodium-acetate--anhydrous and Tuberculosis

The necessity for newer anti-HIV and anti-tubercular medications has arisen as a result of the prevalence of opportunistic infections caused by HIV (human immunodeficiency virus).. A series of ten new hydrazono 1,3-thiazolidin-4-one derivatives were synthesized in one-pot and evaluated for anti-HIV and anti-tubercular activities. Molecular Docking was accomplished with HIV-1 reverse transcriptase protein (PDB ID: 1REV) and Mycobacterium Tuberculosis (M. tuberculosis) H37Rv protein (PDB ID: 2YES) receptors along with drug-likeness and ADMET properties.. One-pot synthesis of hydrazono 1,3-thiazolidin-4-one derivatives was carried out by ketones, thiosemicarbazide and ethylchloroacetate with the catalyst of anhydrous sodium acetate. All the synthesized compounds were characterized and evaluated for their in-vitro anti-HIV and also evaluated for their in-vitro anti-tubercular activity against M. tuberculosis H. From the novel synthesized molecules, none of the molecule is as effective as standards for anti-HIV and anti-tubercular drugs and hence can be further explored for its potential activities. Furthermore, derivatization was made to achieve more potent compounds for anti-HIV and anti-tubercular drugs.

Topics: Antitubercular Agents; Drug Design; HIV Infections; Humans; Ketones; Microbial Sensitivity Tests; Molecular Docking Simulation; Mycobacterium tuberculosis; Sodium Acetate; Structure-Activity Relationship; Tuberculosis

Topics: Acetates; Acetic Acid; Bacillus; Carbon Radioisotopes; Gram-Positive Bacteria; Lacticaseibacillus casei; Mycobacterium bovis; Mycobacterium tuberculosis; Sodium Acetate; Streptomycin; Tuberculosis

Topics: BCG Vaccine; Mycobacterium bovis; Mycobacterium tuberculosis; Sodium Acetate; Tuberculosis; Vaccination; Vaccines