sobuzoxane and Lymphoma, Non-Hodgkin studies

sobuzoxane and Lymphoma, Non-Hodgkin

sobuzoxane: used in treatment of leukemia L1210

Lymphoma, Non-Hodgkin: Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.

Research Excerpts

Excerpt	Relevance	Reference
" On the basis of the synergistic activity in preclinical studies and the schedule dependency in these drugs, low-dose and long-term administration was planned."	2.68	Feasibility of salvage chemotherapy for refractory or relapsed non-Hodgkin's lymphoma with two topoisomerase II inhibitors, MST-16 and VP-16. MST-16 Study Group. ( Ariyoshi, Y; Furue, H; Horiuchi, A; Kagami, Y; Kanamaru, A; Kano, Y; Masaoka, T; Naoe, T; Oguro, M; Ohno, R; Sampi, K; Shirakawa, S, 1996)
"Although razoxane (ICRF-159), a derivative of bis(2,6-dioxopiperazine), has shown significant antitumor activity in several murine tumors, inadequate bioavailability has limited its clinical efficacy."	2.67	Phase II study: treatment of non-Hodgkin's lymphoma with an oral antitumor derivative of bis(2,6-dioxopiperazine). ( Hirano, M; Ikeda, Y; Kodera, Y; Mitomo, Y; Oguri, T; Ohno, R; Shirakawa, S; Tanaka, M; Yamada, K; Yokomaku, S, 1992)
"Leukopenia was observed in 72."	1.28	[Late phase II study of MST-16 (sobuzoxane) on malignant lymphoma]. ( Inagaki, J; Kamiya, O; Kobayashi, M; Mitomo, Y; Nishiwaki, H; Oguri, T; Ohno, R; Tanaka, M; Yamada, K; Yokomaku, S, 1991)

Research

Studies (12)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	7 (58.33)	18.2507
2000's	3 (25.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	2 (16.67)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

0 (0.00)

18.7374

1990's

7 (58.33)

18.2507

2000's

3 (25.00)

29.6817

2010's

0 (0.00)

24.3611

2020's

2 (16.67)

2.80

Authors

Authors	Studies
Fukunaga, A	1
Okamoto, Y	1
Shibata, S	1
Inano, S	1
Takiuchi, Y	1
Yamamoto, K	1
Tabata, S	1
Kitano, T	1
Suzuki, M	1
Tsunoda, S	2
Koyama, D	1
Ikeda, S	1
Sukegawa, M	1
Hojo, H	1
Ohta, M	1
Kobayashi, H	1
Inoue, K	1
Izumi, T	1
Akutsu, M	1
Katano, S	1
Ueda, T	1
Shirai, T	1
Masuda, Y	1
Ohmine, K	1
Nagashima, T	1
Ueda, M	1
Takagi, S	1
Muroi, K	1
Ozawa, K	1
Kano, Y	2
Ohnishi, K	1
Ohno, R	4
Kagami, Y	1
Ariyoshi, Y	2
Horiuchi, A	2
Kanamaru, A	1
Naoe, T	1
Oguro, M	1
Sampi, K	1
Shirakawa, S	2
Masaoka, T	3
Furue, H	1
Okamoto, T	2
Nishimura, Y	1
Yamada, S	2
Itoh, T	1
Mori, A	2
Saheki, K	1
Okada, M	2
Takatsuka, H	2
Wada, H	1
Tamura, A	1
Fujimori, Y	1
Kakishita, E	2
Wakae, T	1
Yamada, K	2
Hirano, M	1
Tanaka, M	2
Oguri, T	2
Kodera, Y	1
Mitomo, Y	2
Ikeda, Y	1
Yokomaku, S	2
Kageyama, T	1
Tatsumi, N	1
Akasaka, K	1
Yonezawa, T	1
Sugiyama, H	1
Kitani, T	1
Yasunaga, K	1
Nakayama, S	2
Yabe, H	1
Nagai, K	1
Tominaga, N	1
Teshima, H	1
Hiraoka, A	1
Suzuki, H	1
Kimura, I	1
Ohnoshi, T	1
Hayashi, K	1
Arima, T	1
Kamiya, O	1
Kobayashi, M	1
Nishiwaki, H	1
Inagaki, J	1

Studies

Fukunaga, A

Okamoto, Y

Shibata, S

Inano, S

Takiuchi, Y

Yamamoto, K

Tabata, S

Kitano, T

Suzuki, M

Tsunoda, S

Koyama, D

Ikeda, S

Sukegawa, M

Hojo, H

Ohta, M

Kobayashi, H

Inoue, K

Izumi, T

Akutsu, M

Katano, S

Ueda, T

Shirai, T

Masuda, Y

Ohmine, K

Nagashima, T

Ueda, M

Takagi, S

Muroi, K

Ozawa, K

Kano, Y

Ohnishi, K

Ohno, R

Kagami, Y

Ariyoshi, Y

Horiuchi, A

Kanamaru, A

Naoe, T

Oguro, M

Sampi, K

Shirakawa, S

Masaoka, T

Furue, H

Okamoto, T

Nishimura, Y

Yamada, S

Itoh, T

Mori, A

Saheki, K

Okada, M

Takatsuka, H

Wada, H

Tamura, A

Fujimori, Y

Kakishita, E

Wakae, T

Yamada, K

Hirano, M

Tanaka, M

Oguri, T

Kodera, Y

Mitomo, Y

Ikeda, Y

Yokomaku, S

Kageyama, T

Tatsumi, N

Akasaka, K

Yonezawa, T

Sugiyama, H

Kitani, T

Yasunaga, K

Nakayama, S

Yabe, H

Nagai, K

Tominaga, N

Teshima, H

Hiraoka, A

Suzuki, H

Kimura, I

Ohnoshi, T

Hayashi, K

Arima, T

Kamiya, O

Kobayashi, M

Nishiwaki, H

Inagaki, J

Reviews

1 review available for sobuzoxane and Lymphoma, Non-Hodgkin

Article	Year
[New antitumor drugs for malignant lymphoma: a review]. Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:8 Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin;	1994

Article

Year

[New antitumor drugs for malignant lymphoma: a review].

Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:8

Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin;

1994

Trials

3 trials available for sobuzoxane and Lymphoma, Non-Hodgkin

Article	Year
Feasibility of salvage chemotherapy for refractory or relapsed non-Hodgkin's lymphoma with two topoisomerase II inhibitors, MST-16 and VP-16. MST-16 Study Group. International journal of hematology, 1996, Volume: 64, Issue:3-4 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Drug Adm	1996
Phase II study: treatment of non-Hodgkin's lymphoma with an oral antitumor derivative of bis(2,6-dioxopiperazine). Journal of the National Cancer Institute, 1992, Mar-18, Volume: 84, Issue:6 Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Drug Evalua	1992
[Late phase II study of MST-16 (sobuzoxane) efficacy for malignant lymphoma]. Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:3 Topics: Adult; Aged; Aged, 80 and over; Anorexia; Antineoplastic Agents; Drug Administration Schedule; Drug	1992

Article

Year

Feasibility of salvage chemotherapy for refractory or relapsed non-Hodgkin's lymphoma with two topoisomerase II inhibitors, MST-16 and VP-16. MST-16 Study Group.

International journal of hematology, 1996, Volume: 64, Issue:3-4

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Drug Adm

1996

Phase II study: treatment of non-Hodgkin's lymphoma with an oral antitumor derivative of bis(2,6-dioxopiperazine).

Journal of the National Cancer Institute, 1992, Mar-18, Volume: 84, Issue:6

Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Drug Evalua

1992

[Late phase II study of MST-16 (sobuzoxane) efficacy for malignant lymphoma].

Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:3

Topics: Adult; Aged; Aged, 80 and over; Anorexia; Antineoplastic Agents; Drug Administration Schedule; Drug

1992

Other Studies

8 other studies available for sobuzoxane and Lymphoma, Non-Hodgkin

Article	Year
Efficacy of salvage therapy with MTX-HOPE for elderly patients with heavily pretreated non-Hodgkin's lymphoma. Journal of clinical and experimental hematopathology : JCEH, 2020, Jun-20, Volume: 60, Issue:2 Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Etoposide; Female; Humans;	2020
MTX-HOPE is a low-dose salvage chemotherapy for aged patients with relapsed or refractory non-Hodgkin lymphoma. Journal of clinical and experimental hematopathology : JCEH, 2021, Mar-18, Volume: 61, Issue:1 Topics: Age Factors; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Drug Resistanc	2021
[MTX-HOPE (methotrexate, hydrocortisone, vincristine, sobuzoxane, and etoposide) as a low-dose salvage chemotherapy for recurrent or refractory non-Hodgkin's lymphoma]. Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:6 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relati	2007
Long-term administration of oral low-dose topoisomerase II inhibitors, MST-16 and VP-16, for refractory or relapsed non-Hodgkin's lymphoma. Acta haematologica, 2000, Volume: 104, Issue:2-3 Topics: Administration, Oral; Adult; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Sch	2000
Secondary acute promyelocytic leukemia in a patient with non-Hodgkin's lymphoma treated with VP-16 and MST-16. International journal of hematology, 2002, Volume: 75, Issue:1 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Cyclophosphamide; Cytarabin	2002
[Clinical treatment of MST-16 (Sobuzoxane) for malignant lymphoma]. Gan to kagaku ryoho. Cancer & chemotherapy, 1991, Volume: 18, Issue:12 Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cycl	1991
[Early phase II study of MST-16 (sobuzoxane) on malignant lymphoma]. Gan to kagaku ryoho. Cancer & chemotherapy, 1991, Volume: 18, Issue:14 Topics: Adult; Aged; Aged, 80 and over; Anorexia; Antineoplastic Agents; Drug Administration Schedule; Drug	1991
[Late phase II study of MST-16 (sobuzoxane) on malignant lymphoma]. Gan to kagaku ryoho. Cancer & chemotherapy, 1991, Volume: 18, Issue:14 Topics: Adult; Aged; Aged, 80 and over; Anorexia; Antineoplastic Agents; Drug Evaluation; Female; Hodgkin Di	1991

Article

Year

Efficacy of salvage therapy with MTX-HOPE for elderly patients with heavily pretreated non-Hodgkin's lymphoma.

Journal of clinical and experimental hematopathology : JCEH, 2020, Jun-20, Volume: 60, Issue:2

Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Etoposide; Female; Humans;

2020

MTX-HOPE is a low-dose salvage chemotherapy for aged patients with relapsed or refractory non-Hodgkin lymphoma.

Journal of clinical and experimental hematopathology : JCEH, 2021, Mar-18, Volume: 61, Issue:1

Topics: Age Factors; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Drug Resistanc

2021

[MTX-HOPE (methotrexate, hydrocortisone, vincristine, sobuzoxane, and etoposide) as a low-dose salvage chemotherapy for recurrent or refractory non-Hodgkin's lymphoma].

Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:6

Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relati

2007

Long-term administration of oral low-dose topoisomerase II inhibitors, MST-16 and VP-16, for refractory or relapsed non-Hodgkin's lymphoma.

Acta haematologica, 2000, Volume: 104, Issue:2-3

Topics: Administration, Oral; Adult; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Sch

2000

Secondary acute promyelocytic leukemia in a patient with non-Hodgkin's lymphoma treated with VP-16 and MST-16.

International journal of hematology, 2002, Volume: 75, Issue:1

Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Cyclophosphamide; Cytarabin

2002

[Clinical treatment of MST-16 (Sobuzoxane) for malignant lymphoma].

Gan to kagaku ryoho. Cancer & chemotherapy, 1991, Volume: 18, Issue:12

Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cycl

1991

[Early phase II study of MST-16 (sobuzoxane) on malignant lymphoma].

Gan to kagaku ryoho. Cancer & chemotherapy, 1991, Volume: 18, Issue:14

Topics: Adult; Aged; Aged, 80 and over; Anorexia; Antineoplastic Agents; Drug Administration Schedule; Drug

1991

[Late phase II study of MST-16 (sobuzoxane) on malignant lymphoma].

Gan to kagaku ryoho. Cancer & chemotherapy, 1991, Volume: 18, Issue:14

Topics: Adult; Aged; Aged, 80 and over; Anorexia; Antineoplastic Agents; Drug Evaluation; Female; Hodgkin Di

1991