snx-230 and Peripheral-Nerve-Injuries

Neuropeptide Y (NPY) modulates nociception in the spinal cord, but little is known about its mechanisms of release. We measured NPY release in situ using the internalization of its Y1 receptor in dorsal horn neurons. Y1 receptor immunoreactivity was normally localized to the cell surface, but addition of NPY to spinal cord slices increased the number of neurons with Y1 internalization in a biphasic fashion (EC

Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arginine; Calcium Channel Blockers; Capsaicin; Cyclic AMP-Dependent Protein Kinases; Excitatory Amino Acid Antagonists; Hyperalgesia; Indoles; Interneurons; Lidocaine; Male; Microscopy, Confocal; Neuropeptide Y; Nociception; omega-Conotoxins; Peripheral Nerve Injuries; Posterior Horn Cells; Potassium Chloride; Protein Transport; Protein Tyrosine Phosphatases; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neuropeptide Y; Sensory System Agents; Spinal Cord; Spinal Nerve Roots; TRPV Cation Channels; Voltage-Gated Sodium Channel Blockers