snx-2112 and Neurodegenerative-Diseases
snx-2112 has been researched along with Neurodegenerative-Diseases* in 1 studies
Other Studies
1 other study(ies) available for snx-2112 and Neurodegenerative-Diseases
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Correlation between chemotype-dependent binding conformations of HSP90α/β and isoform selectivity-Implications for the structure-based design of HSP90α/β selective inhibitors for treating neurodegenerative diseases.
HSP90 continues to be a target of interest for neurodegeneration indications. Selective knockdown of the HSP90 cytosolic isoforms α and β is sufficient to reduce mutant huntingtin protein levels in vitro. Chemotype-dependent binding conformations of HSP90α/β appear to strongly influence isoform selectivity. The rational design of HSP90α/β inhibitors selective versus the mitochondrial (TRAP1) and endoplasmic reticulum (GRP94) isoforms offers a potential mitigating strategy for mechanism-based toxicities. Better tolerated HSP90 inhibitors would be attractive for targeting chronic neurodegenerative diseases such as Huntington's disease. Topics: Crystallography, X-Ray; Drug Design; HSP90 Heat-Shock Proteins; Humans; Models, Molecular; Molecular Structure; Neurodegenerative Diseases; Protein Isoforms | 2014 |