sns-314 and Carcinoma

The aim of this paper is based on the use of a hyaluronic acid hydrogel of Quercetin tested alone and in combination to an inhibitor of Aurora Kinase type A and B (SNS-314) on human medullary and papillary thyroid cancer cells. Biological investigations were focused on the cellular uptake of the hydrogel, cell viability, antioxidant, and cytokines secretion studies. Quercetin delivered from hydrogel show a time and CD44 dependent interaction with both cell lines with significant anti-inflammatory effects. Combination of Quercetin and SNS-314 leads to a synergistic cytotoxic effect on medullary TT and papillary BCPAP cell lines with a significant reduction of the IC50 value. These results, highlights the importance of synergistic effect of the hyaluronic acid hydrogel of Quercetin with SNS-314 in the regulation of human thyroid cancer cell proliferation and emphasize the anti-tumor activity of these molecules. J. Cell. Physiol. 231: 1784-1795, 2016. © 2015 Wiley Periodicals, Inc.

Topics: Anti-Inflammatory Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Aurora Kinase A; Aurora Kinase B; Carcinoma; Carcinoma, Neuroendocrine; Carcinoma, Papillary; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chemistry, Pharmaceutical; Cytokines; Dose-Response Relationship, Drug; Drug Carriers; Drug Synergism; Humans; Hyaluronan Receptors; Hyaluronic Acid; Hydrogels; Inhibitory Concentration 50; Phenylurea Compounds; Protein Kinase Inhibitors; Quercetin; Thiazoles; Thyroid Cancer, Papillary; Thyroid Neoplasms; Time Factors