sm-346 has been researched along with Cognition-Disorders* in 2 studies
1 trial(s) available for sm-346 and Cognition-Disorders
| Article | Year |
|---|---|
[Anxiolytic afobazole action self-evaluated by patients with anxiety-asthenic disorders].
Self-evaluation of single-dose (15 mg) action and course treatment (30 mg daily) results were studied in patients with anxiety and asthenic disorders treated with the new anxiolytic afobazole. Also, relationships between self-evaluated parameters and personal features, clinician-rated therapeutic changes, and treatment effectiveness were analyzed. The study was conducted according to formalized protocol using standard scales and methods. Results suggest that higher self-rated tolerability and patient acceptability were associated with afobazole treatment in comparison to benzodiazepines. The results revealed relationships between self-evaluated single-dose effects of afobazole and other parameters, personal features, cognitive impairments severity, main drug effects, and overall treatment effectiveness. Topics: Adolescent; Adult; Anti-Anxiety Agents; Anxiety; Asthenia; Benzimidazoles; Cognition Disorders; Diagnostic Self Evaluation; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Morpholines; Neuropsychological Tests; Patient Compliance; Patient Satisfaction; Severity of Illness Index; Treatment Outcome; Young Adult | 2010 |
1 other study(ies) available for sm-346 and Cognition-Disorders
| Article | Year |
|---|---|
Effect of Afobazole and Betaine on Cognitive Disorders in the Offspring of Rats with Streptozotocin-Induced Diabetes and Their Relationship with DNA Damage.
Cognitive activity in 60-day-old offspring of rats (intrauterine development in experimental streptozotocin-induced diabetes) was studied on the model of food-seeking behavior under conditions of free choice in a 6-arm maze. The formation of the food-procuring skill was significantly delayed, which attests to impairment of cognitive functions in these animals. Peroral administration of afobazole (10 and 50 mg/kg) and betaine (50 and 100 mg/kg) significantly and dose-dependently alleviated this disorder. Correlation analysis of the data on delayed formation of a food-procuring skill and results of DNA comet attests to a strong relationship between DNA damage in cells of the embryo and placenta during intrauterine development and cognitive dysfunction in the postnatal offspring of animals with streptozotocin-induced diabetes. Topics: Animals; Benzimidazoles; Betaine; Cognition; Cognition Disorders; Comet Assay; Diabetes Mellitus, Experimental; DNA Damage; Female; Male; Morpholines; Pregnancy; Rats | 2016 |