sm-21 and Torticollis

sm-21 has been researched along with Torticollis* in 1 studies

Other Studies

1 other study(ies) available for sm-21 and Torticollis

Article	Year
Pharmacological identification of SM-21, the novel sigma(2) antagonist. Pharmacology, biochemistry, and behavior, 2000, Volume: 67, Issue:3 SM-21 is a tropane analogue with high affinity and selectivity for sigma(2) receptor subtype. In the absence of highly selective sigma(2) antagonists, the aim of the present study was to determine whether SM-21 is endowed with antagonistic activity. The experiments were conducted in rats by inducing neck dystonia, which is reported to be subsequent to activation of sigma(2) receptors. SM-21 (10 nmol/0.5 microl) was able to prevent torsion of the neck obtained by administration of the sigma(1)-sigma(2) agonist 1,3-di-(2-tolyl)guanidine (DTG, 5 nmol/0.5 microl) in the red nucleus. These data indicate that SM-21 is a potent and selective sigma(2) antagonist. Topics: Analgesics; Animals; Anticonvulsants; Butyrates; Guanidines; Male; Rats; Rats, Wistar; Receptors, sigma; Red Nucleus; Torticollis; Tropanes	2000

Article

Year

Pharmacological identification of SM-21, the novel sigma(2) antagonist.

Pharmacology, biochemistry, and behavior, 2000, Volume: 67, Issue:3

SM-21 is a tropane analogue with high affinity and selectivity for sigma(2) receptor subtype. In the absence of highly selective sigma(2) antagonists, the aim of the present study was to determine whether SM-21 is endowed with antagonistic activity. The experiments were conducted in rats by inducing neck dystonia, which is reported to be subsequent to activation of sigma(2) receptors. SM-21 (10 nmol/0.5 microl) was able to prevent torsion of the neck obtained by administration of the sigma(1)-sigma(2) agonist 1,3-di-(2-tolyl)guanidine (DTG, 5 nmol/0.5 microl) in the red nucleus. These data indicate that SM-21 is a potent and selective sigma(2) antagonist.

Topics: Analgesics; Animals; Anticonvulsants; Butyrates; Guanidines; Male; Rats; Rats, Wistar; Receptors, sigma; Red Nucleus; Torticollis; Tropanes

2000