sm-21 and Seizures

sm-21 has been researched along with Seizures* in 1 studies

Other Studies

1 other study(ies) available for sm-21 and Seizures

Article	Year
(+/-)-SM 21 attenuates the convulsive and locomotor stimulatory effects of cocaine in mice. European journal of pharmacology, 2001, Apr-06, Volume: 417, Issue:1-2 Cocaine interacts with sigma receptors at physiologically relevant concentrations. While earlier studies demonstrate that antagonism of sigma(1) receptors attenuates the behavioral actions of cocaine, the contribution of sigma(2) receptors is unclear. Therefore, in the present study, 3 alpha-tropanyl-2-(4-chlorophenoxy)butyrate ((+/-)-SM 21), a compound with high and preferential affinity for sigma(2) receptors, was tested for its ability to attenuate cocaine-induced behaviors. Pre-treatment of Swiss Webster mice with (+/-)-SM 21 significantly attenuated cocaine-induced convulsions and locomotor activity. Topics: Analgesics; Animals; Behavior, Animal; Butyrates; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Mice; Motor Activity; Seizures; Time Factors; Tropanes	2001

Article

Year

(+/-)-SM 21 attenuates the convulsive and locomotor stimulatory effects of cocaine in mice.

European journal of pharmacology, 2001, Apr-06, Volume: 417, Issue:1-2

Cocaine interacts with sigma receptors at physiologically relevant concentrations. While earlier studies demonstrate that antagonism of sigma(1) receptors attenuates the behavioral actions of cocaine, the contribution of sigma(2) receptors is unclear. Therefore, in the present study, 3 alpha-tropanyl-2-(4-chlorophenoxy)butyrate ((+/-)-SM 21), a compound with high and preferential affinity for sigma(2) receptors, was tested for its ability to attenuate cocaine-induced behaviors. Pre-treatment of Swiss Webster mice with (+/-)-SM 21 significantly attenuated cocaine-induced convulsions and locomotor activity.

Topics: Analgesics; Animals; Behavior, Animal; Butyrates; Cocaine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Male; Mice; Motor Activity; Seizures; Time Factors; Tropanes

2001