sl0101 and Prostatic-Neoplasms

sl0101 has been researched along with Prostatic-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for sl0101 and Prostatic-Neoplasms

Article	Year
Substituted indolin-2-ones as p90 ribosomal S6 protein kinase 2 (RSK2) inhibitors: Molecular docking simulation and structure-activity relationship analysis. Bioorganic & medicinal chemistry, 2013, Apr-01, Volume: 21, Issue:7 A series of novel indolin-2-ones inhibitors against p90 ribosomal S6 protein kinase 2 (RSK2) were designed and synthesized and their structure-activity relationship (SAR) was studied. The most potent inhibitor, compound 3s, exhibited potent inhibition against RSK2 with an IC50 value of 0.5 μM and presented a satisfactory selectivity against 23 kinases. The interactions of these inhibitors with RSK2 were investigated based on the proposed binding poses with molecular docking simulation. Four compounds and six compounds exhibited moderate anti-proliferation activities against PC 3 cells and MCF-7 cells, respectively. Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; Indoles; Male; Molecular Docking Simulation; Prostatic Neoplasms; Protein Kinase Inhibitors; Ribosomal Protein S6 Kinases, 90-kDa; Structure-Activity Relationship	2013

Article

Year

Substituted indolin-2-ones as p90 ribosomal S6 protein kinase 2 (RSK2) inhibitors: Molecular docking simulation and structure-activity relationship analysis.

Bioorganic & medicinal chemistry, 2013, Apr-01, Volume: 21, Issue:7

A series of novel indolin-2-ones inhibitors against p90 ribosomal S6 protein kinase 2 (RSK2) were designed and synthesized and their structure-activity relationship (SAR) was studied. The most potent inhibitor, compound 3s, exhibited potent inhibition against RSK2 with an IC50 value of 0.5 μM and presented a satisfactory selectivity against 23 kinases. The interactions of these inhibitors with RSK2 were investigated based on the proposed binding poses with molecular docking simulation. Four compounds and six compounds exhibited moderate anti-proliferation activities against PC 3 cells and MCF-7 cells, respectively.

Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; Indoles; Male; Molecular Docking Simulation; Prostatic Neoplasms; Protein Kinase Inhibitors; Ribosomal Protein S6 Kinases, 90-kDa; Structure-Activity Relationship

2013