sk&f 97541 has been researched along with Gastroesophageal Reflux in 2 studies
3-aminopropyl(methyl)phosphinic acid: structure given in first source; GABA-A receptor antagonist
Gastroesophageal Reflux: Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have previously demonstrated that the prototypical GABA B receptor agonist baclofen inhibits transient lower esophageal sphincter relaxations (TLESRs), the most important mechanism for gastroesophageal reflux." | 3.74 | Synthesis and pharmacological evaluation of novel gamma-aminobutyric acid type B (GABAB) receptor agonists as gastroesophageal reflux inhibitors. ( Alstermark, C; Amin, K; Dinn, SR; Elebring, T; Fitzpatrick, K; Fjellström, O; Geiss, WB; Gottfries, J; Guzzo, PR; Harding, JP; Holmén, A; Kothare, M; Lehmann, A; Mattsson, JP; Nilsson, K; Sundén, G; Swanson, M; von Unge, S; Woo, AM; Wyle, MJ; Zheng, X, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alstermark, C | 1 |
| Amin, K | 1 |
| Dinn, SR | 1 |
| Elebring, T | 1 |
| Fjellström, O | 1 |
| Fitzpatrick, K | 1 |
| Geiss, WB | 1 |
| Gottfries, J | 1 |
| Guzzo, PR | 1 |
| Harding, JP | 1 |
| Holmén, A | 1 |
| Kothare, M | 1 |
| Lehmann, A | 2 |
| Mattsson, JP | 1 |
| Nilsson, K | 1 |
| Sundén, G | 1 |
| Swanson, M | 1 |
| von Unge, S | 1 |
| Woo, AM | 1 |
| Wyle, MJ | 1 |
| Zheng, X | 1 |
| Blackshaw, LA | 1 |
| Staunton, E | 1 |
| Dent, J | 1 |
2 other studies available for sk&f 97541 and Gastroesophageal Reflux
| Article | Year |
|---|---|
Synthesis and pharmacological evaluation of novel gamma-aminobutyric acid type B (GABAB) receptor agonists as gastroesophageal reflux inhibitors.
Topics: Animals; Dose-Response Relationship, Drug; GABA Agonists; GABA-B Receptor Agonists; Gastroesophageal | 2008 |
Inhibition of transient LES relaxations and reflux in ferrets by GABA receptor agonists.
Topics: Animals; Baclofen; Behavior, Animal; Deglutition; Esophagogastric Junction; Female; Ferrets; GABA Ag | 1999 |