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sk&f 97541 and Gastroesophageal Reflux

sk&f 97541 has been researched along with Gastroesophageal Reflux in 2 studies

3-aminopropyl(methyl)phosphinic acid: structure given in first source; GABA-A receptor antagonist

Gastroesophageal Reflux: Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.

Research Excerpts

ExcerptRelevanceReference
"We have previously demonstrated that the prototypical GABA B receptor agonist baclofen inhibits transient lower esophageal sphincter relaxations (TLESRs), the most important mechanism for gastroesophageal reflux."3.74Synthesis and pharmacological evaluation of novel gamma-aminobutyric acid type B (GABAB) receptor agonists as gastroesophageal reflux inhibitors. ( Alstermark, C; Amin, K; Dinn, SR; Elebring, T; Fitzpatrick, K; Fjellström, O; Geiss, WB; Gottfries, J; Guzzo, PR; Harding, JP; Holmén, A; Kothare, M; Lehmann, A; Mattsson, JP; Nilsson, K; Sundén, G; Swanson, M; von Unge, S; Woo, AM; Wyle, MJ; Zheng, X, 2008)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's1 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Alstermark, C1
Amin, K1
Dinn, SR1
Elebring, T1
Fjellström, O1
Fitzpatrick, K1
Geiss, WB1
Gottfries, J1
Guzzo, PR1
Harding, JP1
Holmén, A1
Kothare, M1
Lehmann, A2
Mattsson, JP1
Nilsson, K1
Sundén, G1
Swanson, M1
von Unge, S1
Woo, AM1
Wyle, MJ1
Zheng, X1
Blackshaw, LA1
Staunton, E1
Dent, J1

Other Studies

2 other studies available for sk&f 97541 and Gastroesophageal Reflux

ArticleYear
Synthesis and pharmacological evaluation of novel gamma-aminobutyric acid type B (GABAB) receptor agonists as gastroesophageal reflux inhibitors.
    Journal of medicinal chemistry, 2008, Jul-24, Volume: 51, Issue:14

    Topics: Animals; Dose-Response Relationship, Drug; GABA Agonists; GABA-B Receptor Agonists; Gastroesophageal

2008
Inhibition of transient LES relaxations and reflux in ferrets by GABA receptor agonists.
    The American journal of physiology, 1999, Volume: 277, Issue:4

    Topics: Animals; Baclofen; Behavior, Animal; Deglutition; Esophagogastric Junction; Female; Ferrets; GABA Ag

1999