sk&f 91488 has been researched along with Muscle Contraction in 4 studies
SK&F 91488: RN given refers to parent cpd; structure given in first source; PI: APT (80-92) (not an active MH record; now NM)
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Histamine dose-dependently induced the contraction of sections of the guinea-pig small intestine, and the pretreatment of the tissue section with aminoguanidine (100 microM), a diamine oxidase inhibitor, but not with S-[4-(N,N-dimethylamino)butyl]isothiourea (100 microM), an inhibitor of histamine N-methyltransferase, shifted the dose-response curve of histamine-induced contraction to lower concentrations." | 1.31 | Expression of diamine oxidase (histaminase) in guinea-pig tissues. ( Kitanaka, J; Kitanaka, N; Takemura, M; Terada, N; Tsujimura, T, 2002) |
| " Conversely, following potentiation of the response to histamine with DTT, exposure of the tissue to desensitizing concentrations of histamine resulted in a dextral shift of the dose-response curve (dose ratio = 39." | 1.27 | Selective enhancement of histamine H1-receptor responses in guinea-pig ileal smooth muscle by 1,4-dithiothreitol. ( Donaldson, J; Hill, SJ, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Malmberg-Aiello, P | 1 |
| Lamberti, C | 1 |
| Ipponi, A | 1 |
| Hänninen, J | 1 |
| Ghelardini, C | 1 |
| Bartolini, A | 1 |
| Kitanaka, J | 1 |
| Kitanaka, N | 1 |
| Tsujimura, T | 1 |
| Terada, N | 1 |
| Takemura, M | 2 |
| Ohrui, T | 1 |
| Yamauchi, K | 1 |
| Sekizawa, K | 1 |
| Ohkawara, Y | 1 |
| Maeyama, K | 1 |
| Sasaki, M | 1 |
| Wada, H | 1 |
| Watanabe, T | 1 |
| Sasaki, H | 1 |
| Donaldson, J | 1 |
| Hill, SJ | 1 |
4 other studies available for sk&f 91488 and Muscle Contraction
| Article | Year |
|---|---|
Effects of two histamine-N-methyltransferase inhibitors, SKF 91488 and BW 301 U, in rodent antinociception.
Topics: Analgesics; Animals; Dimaprit; Dose-Response Relationship, Drug; Enzyme Inhibitors; Folic Acid Antag | 1997 |
Expression of diamine oxidase (histaminase) in guinea-pig tissues.
Topics: Amine Oxidase (Copper-Containing); Animals; Brain; Dimaprit; Dose-Response Relationship, Drug; Gastr | 2002 |
Histamine N-methyltransferase controls the contractile response of guinea pig trachea to histamine.
Topics: Animals; Dimaprit; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; Histamine; Histamine N | 1992 |
Selective enhancement of histamine H1-receptor responses in guinea-pig ileal smooth muscle by 1,4-dithiothreitol.
Topics: Acetylcholine; Animals; Dimaprit; Dithionitrobenzoic Acid; Dithiothreitol; Dose-Response Relationshi | 1986 |