sk&f 86002 has been researched along with Shock, Septic in 2 studies
6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole: inhibits p38 MAP kinase
Shock, Septic: Sepsis associated with HYPOTENSION or hypoperfusion despite adequate fluid resuscitation. Perfusion abnormalities may include but are not limited to LACTIC ACIDOSIS; OLIGURIA; or acute alteration in mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of a new, structurally novel, dual inhibitor of arachidonic acid (AA) metabolism, SK&F 86002, was studied in two murine models of endotoxin shock." | 7.67 | Protective effect of SK&F 86002, a novel dual inhibitor of arachidonic acid metabolism, in murine models of endotoxin shock: inhibition of tumor necrosis factor as a possible mechanism of action. ( Badger, AM; Hanna, N; Olivera, D; Talmadge, JE, 1989) |
| "The effect of a new, structurally novel, dual inhibitor of arachidonic acid (AA) metabolism, SK&F 86002, was studied in two murine models of endotoxin shock." | 3.67 | Protective effect of SK&F 86002, a novel dual inhibitor of arachidonic acid metabolism, in murine models of endotoxin shock: inhibition of tumor necrosis factor as a possible mechanism of action. ( Badger, AM; Hanna, N; Olivera, D; Talmadge, JE, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Olivera, DL | 1 |
| Laydon, JT | 1 |
| Hillegass, L | 1 |
| Badger, AM | 2 |
| Lee, JC | 1 |
| Olivera, D | 1 |
| Talmadge, JE | 1 |
| Hanna, N | 1 |
2 other studies available for sk&f 86002 and Shock, Septic
| Article | Year |
|---|---|
Effects of pyridinyl imidazole compounds on murine TNF-alpha production.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cells, Cultured; Enzyme-Linked Immunoso | 1993 |
Protective effect of SK&F 86002, a novel dual inhibitor of arachidonic acid metabolism, in murine models of endotoxin shock: inhibition of tumor necrosis factor as a possible mechanism of action.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Dexamethasone; Disease Models, Animal; Galactosamine; | 1989 |