sk&f 86002 has been researched along with Polyarthritis in 2 studies
6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole: inhibits p38 MAP kinase
| Excerpt | Relevance | Reference |
|---|---|---|
| " One of the compounds, 9 (SB 210313) which lacked measureable activity as an inhibitor of the enzymes of arachidonate metabolism, and had good potency in the binding and in vivo TNF inhibition assays, was tested for antiarthritic activity in the AA rat model of arthritis." | 3.69 | 1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency. ( Adams, JL; Badger, AM; Boehm, JC; Bradbeer, J; Breton, JJ; Chabot-Fletcher, MC; Gallagher, TF; Garigipati, RS; Griswold, DE; Hillegass, LM; Laydon, JT; Lee, JC; Sheldrake, PL; Smietana, JM; Sorenson, ME, 1996) |
| "The dual inhibitors of arachidonic acid metabolism, Smith Kline & French (SK&F) 86002, SK&F 104351, and phenidone; the corticosteroid, dexamethasone; and the selective cyclooxygenase inhibitors, ibuprofen, indomethacin, naproxen, and piroxicam were evaluated for their antiarthritic potency in the murine, collagen-induced arthritis model." | 3.67 | Effect of inhibitors of eicosanoid metabolism in murine collagen-induced arthritis. ( DiMartino, MJ; Griswold, DE; Hanna, N; Hillegass, LM; Meunier, PC, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Boehm, JC | 1 |
| Smietana, JM | 1 |
| Sorenson, ME | 1 |
| Garigipati, RS | 1 |
| Gallagher, TF | 1 |
| Sheldrake, PL | 1 |
| Bradbeer, J | 1 |
| Badger, AM | 1 |
| Laydon, JT | 1 |
| Lee, JC | 1 |
| Hillegass, LM | 2 |
| Griswold, DE | 2 |
| Breton, JJ | 1 |
| Chabot-Fletcher, MC | 1 |
| Adams, JL | 1 |
| Meunier, PC | 1 |
| DiMartino, MJ | 1 |
| Hanna, N | 1 |
2 other studies available for sk&f 86002 and Polyarthritis
| Article | Year |
|---|---|
1-substituted 4-aryl-5-pyridinylimidazoles: a new class of cytokine suppressive drugs with low 5-lipoxygenase and cyclooxygenase inhibitory potency.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Art | 1996 |
Effect of inhibitors of eicosanoid metabolism in murine collagen-induced arthritis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arthritis; Collagen; Dexamethasone; Ibuprofen; Imidazo | 1988 |