sk&f-38393 has been researched along with Seizures in 14 studies
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine: A selective D1 dopamine receptor agonist used primarily as a research tool.
1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol : A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine bearing a phenyl substituent at position 1 and two hydroxy substituents at positions 7 and 8.
SKF 38393 : A racemate comprising equimolar amounts of (R)- and (S)-SKF 38393
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "An assortment of glutamate antagonists with differing selectivities for NMDA and AMPA-type glutamate receptors, were tested for their effects in the mouse pilocarpine model of complex partial seizures." | 7.68 | Glutamate-dopamine interactions in the production of pilocarpine motor seizures in the mouse. ( Starr, BS; Starr, MS, 1993) |
| "The present study addressed the role of dopamine D1 receptors in pilocarpine-induced motor seizures in rats." | 7.68 | Dopaminergic modulation of pilocarpine-induced motor seizures in the rat: the role of hippocampal dopamine D1 receptors. ( Alam, AM; Starr, MS, 1992) |
| "An assortment of glutamate antagonists with differing selectivities for NMDA and AMPA-type glutamate receptors, were tested for their effects in the mouse pilocarpine model of complex partial seizures." | 3.68 | Glutamate-dopamine interactions in the production of pilocarpine motor seizures in the mouse. ( Starr, BS; Starr, MS, 1993) |
| "The present study addressed the role of dopamine D1 receptors in pilocarpine-induced motor seizures in rats." | 3.68 | Dopaminergic modulation of pilocarpine-induced motor seizures in the rat: the role of hippocampal dopamine D1 receptors. ( Alam, AM; Starr, MS, 1992) |
| "This study investigates the role of forebrain D1 receptors in the motor expression of seizures induced by pilocarpine." | 3.68 | Anticonvulsant action of SCH 23390 in the striatum of the rat. ( al-Tajir, G; Starr, MS, 1990) |
| " This work presents evidence that bilateral microinjection of the DAD1 agonist SKF-38393 into the substantia nigra enhances the susceptibility of rats to seizures, with an ED50 of 20 pmol (range 13-31 pmol), converting subconvulsant doses of the cholinergic agonist pilocarpine (200 mg/kg; i." | 3.68 | Dopamine control of seizure propagation: intranigral dopamine D1 agonist SKF-38393 enhances susceptibility to seizures. ( Bortolotto, ZA; Cavalheiro, EA; Ikonomidou, C; Klockgether, T; Turski, L; Turski, WA, 1990) |
| "Focal, limbic seizures were produced by systemically administered pilocarpine (200 mg/kg, i." | 3.67 | D-1 dopamine agonist administration reduces the threshold for convulsions produced by pilocarpine. ( Barone, P; Campanella, G; Chase, TN; Marin, C; Palma, V; Parashos, SA, 1989) |
| "Here, we have investigated the anti-seizure effects of the novel and potent allosteric modulator of sigma-1 receptors, SKF83959 and its derivative SOMCL-668 (3-methyl-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol)." | 1.42 | Allosteric modulation of sigma-1 receptors elicits anti-seizure activities. ( Chen, Y; Friedman, E; Guo, L; Wang, G; Zhang, A; Zhao, R; Zhen, X, 2015) |
| "SKF 83822-induced behavioral and EEG seizures were gene dose-dependently abolished in D(1) knockouts." | 1.35 | Dopamine D1 vs D5 receptor-dependent induction of seizures in relation to DARPP-32, ERK1/2 and GluR1-AMPA signalling. ( Clementi, M; Croke, DT; Drago, J; Dunleavy, M; Fienberg, AA; Fisone, G; Greengard, P; Hakansson, K; Henshall, DC; Kinsella, A; O'Sullivan, GJ; Sibley, DR; Waddington, JL, 2008) |
| "Seven days post-seizure, the ECS group showed significantly more locomotion following intraperitoneal administration of apomorphine (0." | 1.32 | The effect of electroconvulsive shock seizures on behaviour induced by dopaminergic agonists and on immobility in the Porsolt test. ( Burnham, WM; Sahebgharani, M; Zarrindast, MR, 2004) |
| "Acute cocaine overdose can result in convulsions and death although the mechanisms associated with this toxicity are poorly understood." | 1.29 | Role of dopamine D1 receptors in the lethal effects of cocaine and a quaternary methiodide analog. ( Katz, JL; Newman, AH; Nowak, G; Witkin, JM, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (21.43) | 18.7374 |
| 1990's | 8 (57.14) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guo, L | 1 |
| Chen, Y | 1 |
| Zhao, R | 1 |
| Wang, G | 1 |
| Friedman, E | 1 |
| Zhang, A | 1 |
| Zhen, X | 1 |
| Zarrindast, MR | 1 |
| Sahebgharani, M | 1 |
| Burnham, WM | 1 |
| O'Sullivan, GJ | 1 |
| Dunleavy, M | 1 |
| Hakansson, K | 1 |
| Clementi, M | 1 |
| Kinsella, A | 1 |
| Croke, DT | 1 |
| Drago, J | 1 |
| Fienberg, AA | 1 |
| Greengard, P | 1 |
| Sibley, DR | 1 |
| Fisone, G | 1 |
| Henshall, DC | 1 |
| Waddington, JL | 1 |
| Witkin, JM | 1 |
| Newman, AH | 1 |
| Nowak, G | 1 |
| Katz, JL | 1 |
| Starr, MS | 4 |
| Starr, BS | 1 |
| Alam, AM | 2 |
| Wahnschaffe, U | 1 |
| Löscher, W | 1 |
| al-Tajir, G | 1 |
| Turski, WA | 1 |
| Cavalheiro, EA | 1 |
| Ikonomidou, C | 1 |
| Bortolotto, ZA | 1 |
| Klockgether, T | 1 |
| Turski, L | 1 |
| Barone, P | 2 |
| Parashos, SA | 2 |
| Palma, V | 2 |
| Marin, C | 2 |
| Campanella, G | 2 |
| Chase, TN | 2 |
| Newman, ME | 1 |
| Lerer, B | 1 |
| Trzaskowska, E | 1 |
| Krzaścik, P | 1 |
| Staniszewska, A | 1 |
| Puciłowski, O | 1 |
| Kostowski, W | 1 |
14 other studies available for sk&f-38393 and Seizures
| Article | Year |
|---|---|
Allosteric modulation of sigma-1 receptors elicits anti-seizure activities.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Anticonvulsants; Benzazepines; | 2015 |
The effect of electroconvulsive shock seizures on behaviour induced by dopaminergic agonists and on immobility in the Porsolt test.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amphetamine; Animals; Apomorphine; Behav | 2004 |
Dopamine D1 vs D5 receptor-dependent induction of seizures in relation to DARPP-32, ERK1/2 and GluR1-AMPA signalling.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Corpus Striatum; | 2008 |
Role of dopamine D1 receptors in the lethal effects of cocaine and a quaternary methiodide analog.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Cocaine; Dopamine | 1993 |
Glutamate-dopamine interactions in the production of pilocarpine motor seizures in the mouse.
Topics: 2-Amino-5-phosphonovalerate; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Di | 1993 |
Dopaminergic modulation of pilocarpine-induced motor seizures in the rat: the role of hippocampal D2 receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Dopamine; Dopamine Agents; Dopa | 1993 |
Dopaminergic modulation of pilocarpine-induced motor seizures in the rat: the role of hippocampal dopamine D1 receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Drug Interactions | 1992 |
Anticonvulsant effects of ipsilateral but not contralateral microinjections of the dopamine D2 agonist LY 171555 into the nucleus accumbens of amygdala-kindled rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amygdala; Animals; Anticonvulsants; Dopa | 1991 |
Anticonvulsant action of SCH 23390 in the striatum of the rat.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Anticonvulsants; Antiparkinson | 1990 |
Dopamine control of seizure propagation: intranigral dopamine D1 agonist SKF-38393 enhances susceptibility to seizures.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Corpus Striatum; Dopamine; Dose | 1990 |
Dopamine D1 receptor modulation of pilocarpine-induced convulsions.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Dose-Response Relationship, Dru | 1990 |
D-1 dopamine agonist administration reduces the threshold for convulsions produced by pilocarpine.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Convulsants; Dopa | 1989 |
Effects of chronic electroconvulsive shock on D1 and D2 dopamine receptor-mediated activity of adenylate cyclase in homogenates of striatum and limbic forebrain of rat.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; Benzazepines | 1989 |
On the relative importance of D-1 vs. D-2 dopaminergic receptors in the control of audiogenic seizures in ethanol withdrawn rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acoustic Stimulation; Animals; Benzazepi | 1989 |