sk&f-38393 has been researched along with Pregnancy in 54 studies
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine: A selective D1 dopamine receptor agonist used primarily as a research tool.
1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol : A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine bearing a phenyl substituent at position 1 and two hydroxy substituents at positions 7 and 8.
SKF 38393 : A racemate comprising equimolar amounts of (R)- and (S)-SKF 38393
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| " A dose-response curve demonstrated that the dopamine D1 receptor agonist, SKF 38393, produced a maximal response in 6-OHDA-treated rats at a dose of 0." | 1.28 | Supersensitized D1 receptors mediate enhanced oral activity after neonatal 6-OHDA. ( Gong, L; Kostrzewa, RM, 1991) |
| " Behaviors measured on day 15 revealed that SKF 38393-treated groups displayed significant deficits, in comparison to controls, in spontaneous alternation and decision-making: less alternation and more vacillatory behavior at every dosage tested." | 1.28 | SKF 38393: vacillatory behavior in immature rats. ( Molino, LJ; Shemer, A; Whitaker-Azmitia, PM, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (11.11) | 18.7374 |
| 1990's | 31 (57.41) | 18.2507 |
| 2000's | 15 (27.78) | 29.6817 |
| 2010's | 1 (1.85) | 24.3611 |
| 2020's | 1 (1.85) | 2.80 |
| Authors | Studies |
|---|---|
| Grieb, ZA | 1 |
| Vitale, EM | 1 |
| Morrell, JI | 1 |
| Lonstein, JS | 1 |
| Pereira, M | 1 |
| Jackson, CR | 1 |
| Capozzi, M | 1 |
| Dai, H | 1 |
| McMahon, DG | 1 |
| McNamara, RK | 1 |
| Able, J | 1 |
| Jandacek, R | 1 |
| Rider, T | 1 |
| Tso, P | 1 |
| Lindquist, DM | 1 |
| Numan, M | 2 |
| Stolzenberg, DS | 2 |
| Brus, R | 2 |
| Kostrzewa, RM | 7 |
| Nowak, P | 1 |
| Perry, KW | 3 |
| Kostrzewa, JP | 1 |
| Zhang, L | 1 |
| Bai, J | 1 |
| Undie, AS | 1 |
| Bergson, C | 1 |
| Lidow, MS | 1 |
| Eaton, ME | 1 |
| Macías, W | 1 |
| Youngs, RM | 1 |
| Rajadhyaksha, A | 1 |
| Dudman, JT | 1 |
| Konradi, C | 1 |
| Voulalas, PJ | 1 |
| Holtzclaw, L | 1 |
| Wolstenholme, J | 1 |
| Russell, JT | 1 |
| Hyman, SE | 1 |
| Olesen, KM | 1 |
| Jessen, HM | 1 |
| Auger, CJ | 1 |
| Auger, AP | 1 |
| Sivam, SP | 1 |
| Cox, J | 1 |
| Tseng, KY | 1 |
| Lewis, BL | 1 |
| Lipska, BK | 1 |
| O'Donnell, P | 1 |
| McKenna, JB | 1 |
| Keough, S | 1 |
| Hancock, R | 1 |
| Numan, MJ | 1 |
| Weaver, DR | 3 |
| Roca, AL | 1 |
| Reppert, SM | 2 |
| Huang, NY | 1 |
| Viswanathan, N | 2 |
| Davis, FC | 3 |
| Varlinskaya, EI | 1 |
| Petrov, ES | 1 |
| Robinson, SR | 4 |
| Smotherman, WP | 4 |
| Shieh, GJ | 1 |
| Walters, DE | 1 |
| Moody, CA | 3 |
| Spear, LP | 3 |
| Fuller, RW | 2 |
| Neely, D | 1 |
| Kowalski, C | 1 |
| Giraud, P | 1 |
| Laprade, N | 2 |
| Radja, F | 1 |
| Reader, TA | 1 |
| Soghomonian, JJ | 2 |
| Schoffelmeer, AN | 2 |
| Voorn, P | 1 |
| Jonker, AJ | 1 |
| Wardeh, G | 2 |
| Nestby, P | 2 |
| Vanderschuren, LJ | 2 |
| De Vries, TJ | 2 |
| Mulder, AH | 2 |
| Tjon, GH | 2 |
| Okamura, H | 1 |
| Murakami, T | 1 |
| Yokoyama, C | 1 |
| Nakamura, T | 1 |
| Ibata, Y | 1 |
| Wan, RQ | 1 |
| Corbett, R | 1 |
| Sajnani, GG | 1 |
| Abreu, P | 1 |
| Castro, R | 1 |
| Bender, M | 1 |
| Drago, J | 1 |
| Rivkees, SA | 1 |
| Sandstrom, M | 1 |
| Bruno, JP | 1 |
| Kim, EY | 1 |
| Koh, JY | 1 |
| Kim, YH | 1 |
| Sohn, S | 1 |
| Joe, E | 1 |
| Gwag, BJ | 1 |
| Grosse, J | 1 |
| Ferguson, SA | 2 |
| Rowe, SA | 1 |
| Krupa, M | 1 |
| Kennaway, DJ | 2 |
| Kang, DK | 1 |
| Kim, KO | 1 |
| Lee, SH | 1 |
| Lee, YS | 1 |
| Son, H | 1 |
| Shearman, LP | 1 |
| Boksa, P | 1 |
| Zhang, Y | 1 |
| Bestawros, A | 1 |
| Segar, JL | 1 |
| Smith, FG | 1 |
| Guillery, EN | 1 |
| Jose, PA | 1 |
| Robillard, JE | 1 |
| Simson, PE | 1 |
| Johnson, KB | 1 |
| Jurevics, HA | 1 |
| Criswell, HE | 3 |
| Napier, TC | 4 |
| Duncan, GE | 2 |
| Mueller, RA | 6 |
| Breese, GR | 5 |
| Gong, L | 2 |
| Yurek, DM | 1 |
| Steece-Collier, K | 1 |
| Collier, TJ | 1 |
| Sladek, JR | 1 |
| Hamdi, A | 1 |
| McQuade, RD | 1 |
| Iorio, LC | 2 |
| Whitaker-Azmitia, PM | 3 |
| Quartermain, D | 1 |
| Shemer, AV | 2 |
| Molino, LJ | 2 |
| Caruso, J | 1 |
| Breese, GA | 1 |
| Shemer, A | 1 |
| Moresco, RM | 1 |
| Dall'Olio, R | 1 |
| Gandolfi, O | 1 |
| Govoni, S | 1 |
| Di Giovine, S | 1 |
| Trabucchi, M | 1 |
| Bondy, SC | 1 |
| Baumeister, A | 1 |
| Frye, GD | 1 |
1 review available for sk&f-38393 and Pregnancy
| Article | Year |
|---|---|
Medial preoptic area interactions with dopamine neural systems in the control of the onset and maintenance of maternal behavior in rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Animals, Newborn; Baclofen; Ben | 2009 |
53 other studies available for sk&f-38393 and Pregnancy
| Article | Year |
|---|---|
Decreased mesolimbic dopaminergic signaling underlies the waning of maternal caregiving across the postpartum period in rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Animals, Newborn; Dopamine; Dop | 2020 |
Circadian perinatal photoperiod has enduring effects on retinal dopamine and visual function.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Animals, Newborn; Benzamides; C | 2014 |
Perinatal n-3 fatty acid deficiency selectively reduces myo-inositol levels in the adult rat PFC: an in vivo (1)H-MRS study.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; alpha-Linolenic Acid; Animals; Animals, | 2009 |
Ontogenetic quinpirole treatments fail to prime for D2 agonist-enhancement of locomotor activity in 6-hydroxydopamine-lesioned rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Biogenic Monoamines; Den | 2003 |
D1 dopamine receptor regulation of the levels of the cell-cycle-controlling proteins, cyclin D, P27 and Raf-1, in cerebral cortical precursor cells is mediated through cAMP-independent pathways.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Cell Cycle; Cell Cycle Proteins | 2005 |
L-type Ca2+ channel blockers promote Ca2+ accumulation when dopamine receptors are activated in striatal neurons.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Calcium; Calcium Channel Blocke | 2004 |
Metabotropic glutamate receptors and dopamine receptors cooperate to enhance extracellular signal-regulated kinase phosphorylation in striatal neurons.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Benzazepi | 2005 |
Dopaminergic activation of estrogen receptors in neonatal brain alters progestin receptor expression and juvenile social play behavior.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Animals, Newborn; Behavior, Ani | 2005 |
Postnatal administration of D1 dopamine agonist reverses neonatal dopaminergic lesion-induced changes in striatal enkephalin and substance P systems.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 3,4-Dihydroxyphenylacetic Acid; Adrenerg | 2006 |
Post-pubertal disruption of medial prefrontal cortical dopamine-glutamate interactions in a developmental animal model of schizophrenia.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazo | 2007 |
Dopamine D1 receptor stimulation of the nucleus accumbens or the medial preoptic area promotes the onset of maternal behavior in pregnancy-terminated rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Abortion, Induced; Animals; Dopamine Ago | 2007 |
c-fos and jun-B mRNAs are transiently expressed in fetal rodent suprachiasmatic nucleus following dopaminergic stimulation.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Circadian Rhythm; Cocaine; Dopa | 1995 |
Enhanced oral activity response to A77636 in neonatal 6-hydroxydopamine-lesioned rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adamantane; Analysis of Variance; Animal | 1994 |
Entrainment of the fetal hamster circadian pacemaker by prenatal injections of the dopamine agonist SKF 38393.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Circadian Rhythm; Cricetinae; D | 1994 |
Intracisternal administration of SKF-38393 and SCH-23390: behavioral effects in the rat fetus.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Benzazepines; | 1994 |
Altered neurochemical and behavioral development of 10-day-old rats perinatally exposed to the kappa opioid agonist U-50,488H.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidin | 1994 |
Fetal behavior and the dopamine system: activity effects of D1 and D2 receptor manipulations.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Benzazepines; | 1993 |
Supersensitization of the oral response to SKF 38393 in neonatal 6-hydroxydopamine-lesioned rats is eliminated by neonatal 5,7-dihydroxytryptamine treatment.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 5,7-Dihydroxytryptamine; Animals; Corpus | 1994 |
Enhanced pilocarpine-induced oral activity responses in neonatal 6-OHDA treated rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Animals, Newborn; Behavior, Ani | 1993 |
Fetal behavior and the endogenous opioid system: D1 dopamine receptor interactions with the kappa opioid system.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analgesics; Animals; Arousal; Benzazepin | 1993 |
Effects of dopamine and kappa opioid receptors on fetal responsiveness to perioral stimuli.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidin | 1993 |
Dopamine decreases striatal enkephalin turnover and proenkephalin messenger RNA abundance via D2 receptor activation in primary striatal cell cultures.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Blotting, Northern; Bromocripti | 1993 |
Dopamine receptor agonists regulate levels of the serotonin 5-HT2A receptor and its mRNA in a subpopulation of rat striatal neurons.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic Agents; Amphetamines; Animals | 1996 |
Morphine-induced increase in D-1 receptor regulated signal transduction in rat striatal neurons and its facilitation by glucocorticoid receptor activation: possible role in behavioral sensitization.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Amphetamine; Animals; | 1996 |
Self-injurious behavior and dopaminergic neuron system in neonatal 6-hydroxydopamine-lesioned rat: 2. Intracerebral microinjection of dopamine agonists and antagonists.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Animals, Newborn; Benzazepines; | 1997 |
Enhancement of postsynaptic sensitivity to dopaminergic agonists induced by neonatal hippocampal lesions.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amphetamine; Animals; Animals, Newborn; | 1997 |
Intermittent morphine administration induces a long-lasting synergistic effect of corticosterone on dopamine D1 receptor functioning in rat striatal GABA neurons.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenosine Triphosphate; Adenylyl Cyclase | 1997 |
Single prenatal injections of melatonin or the D1-dopamine receptor agonist SKF 38393 to pregnant hamsters sets the offsprings' circadian rhythms to phases 180 degrees apart.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Circadian Rhythm; Cricetinae; F | 1997 |
Pre/postnatal dopamine D1 receptor stimulation induces a differential reduction of serotonin levels in hippocampus and superior colliculus of puber rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 3,4-Dihydroxyphenylacetic Acid; Aging; A | 1997 |
D1 receptors mediate dopamine action in the fetal suprachiasmatic nuclei: studies of mice with targeted deletion of the D1 dopamine receptor gene.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Autoradiography; Benzazepines; | 1997 |
c-fos gene expression is induced in a subpopulation of striatal neurons following a single administration of a dopamine D1-receptor agonist in adult rats lesioned with 6-OHDA as neonates.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Animals, Newborn; Corpus Striat | 1998 |
Zn2+ entry produces oxidative neuronal necrosis in cortical cell cultures.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; 6-Cyano-7-nitroquinoxaline-2,3-dione; al | 1999 |
Transient entrainment of a circadian pacemaker during development by dopaminergic activation in Syrian hamsters.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Circadian Rhythm; Cricet | 1999 |
Prenatal exposure to the dopamine agonist SKF-38393 disrupts the timing of the initial response of the suprachiasmatic nucleus to light.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antibodies; Circadian Rhythm; D | 2000 |
Prenatal exposure to SKF-38393 alters the response to light of adult rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Age Factors; Animals; Circadian Rhythm; | 2000 |
c-Fos expression by dopaminergic receptor activation in rat hippocampal neurons.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Cells, Cultured; Colforsin; Cyc | 2000 |
Distinct pharmacological mechanisms leading to c-fos gene expression in the fetal suprachiasmatic nucleus.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenosine; Animals; Caffeine; Central Ne | 2001 |
Dopamine D1 receptor changes due to caesarean section birth: effects of anesthesia, developmental time course, and functional consequences.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amphetamines; Anesthetics, Inhalation; A | 2002 |
Ontogeny of renal response to specific dopamine DA1-receptor stimulation in sheep.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Arteries; Blood Pressure; Dopam | 1992 |
Augmented sensitivity of D1-dopamine receptors in lateral but not medial striatum after 6-hydroxydopamine-induced lesions in the neonatal rat.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenylyl Cyclases; Animals; Animals, New | 1992 |
Supersensitization of the oral response to SKF 38393 in neonatal 6-OHDA-lesioned rats is mediated through a serotonin system.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Animals, Newborn; Behavior, Ani | 1992 |
Chronic levodopa impairs the recovery of dopamine agonist-induced rotational behavior following neural grafting.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amphetamine; Animals; Brain Tissue Trans | 1991 |
Supersensitized D1 receptors mediate enhanced oral activity after neonatal 6-OHDA.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Animals, Newborn; Benzazepines; | 1991 |
Ontogenic homologous supersensitization of dopamine D1 receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Animals, Newborn; Corpus | 1991 |
Pharmacological evaluation of SCH-12679: evidence for an in vivo antagonism of D1-dopamine receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aggression; Animals; Antipsychotic Agent | 1990 |
Prenatal treatment with a selective D1 receptor agonist (SKF 38393) alters adult [3H]paroxetine binding and dopamine and serotonin behavioral sensitivity.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Brain Stem; C | 1990 |
Serotonergic agents restore appropriate decision-making in neonatal rats displaying dopamine D1 receptor-mediated vacillatory behavior.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Animals, Newborn; Behavior, Ani | 1990 |
Clozapine antagonism of D-1 and D-2 dopamine receptor-mediated behaviors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Animals, Newborn; Appetite Depr | 1989 |
SKF 38393: vacillatory behavior in immature rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Benzazepines; | 1989 |
Lead neurotoxicity: a role for dopamine receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Apomorphine; Behavior, Animal; | 1988 |
6-hydroxydopamine treatments enhance behavioral responses to intracerebral microinjection of D1- and D2-dopamine agonists into nucleus accumbens and striatum without changing dopamine antagonist binding.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Animals, Newborn; Behavior, Ani | 1987 |
Dopamine agonist-induced locomotor activity in rats treated with 6-hydroxydopamine at differing ages: functional supersensitivity of D-1 dopamine receptors in neonatally lesioned rats.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Age Factors; Animals; Animals, Newborn; | 1985 |
Evidence that D-1 dopamine receptors contribute to the supersensitive behavioral responses induced by L-dihydroxyphenylalanine in rats treated neonatally with 6-hydroxydopamine.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analysis of Variance; Animals; Animals, | 1985 |