Page last updated: 2024-10-21

sk&f-38393 and Obesity

sk&f-38393 has been researched along with Obesity in 8 studies

2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine: A selective D1 dopamine receptor agonist used primarily as a research tool.
1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol : A benzazepine that is 2,3,4,5-tetrahydro-3-benzazepine bearing a phenyl substituent at position 1 and two hydroxy substituents at positions 7 and 8.
SKF 38393 : A racemate comprising equimolar amounts of (R)- and (S)-SKF 38393

Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).

Research Excerpts

ExcerptRelevanceReference
"Rosiglitazone treatment resulted in restoration of G-protein coupling of D1A receptors and their recruitment by dopamine in obese rats similar to that seen in lean rats."1.32Rosiglitazone restores G-protein coupling, recruitment, and function of renal dopamine D1A receptor in obese Zucker rats. ( Lokhandwala, M; Marwaha, A; Trivedi, M, 2004)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (37.50)18.2507
2000's5 (62.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Marwaha, A4
Lokhandwala, MF4
Trivedi, M1
Lokhandwala, M1
Banday, AA2
Tallam, LS1
Fazili, FR1
Cincotta, AH3
Tozzo, E2
Scislowski, PW2
Zhang, Y1
Phaneuf, S1
Prevelige, R1
Hussain, T1
Beheray, SA1
Kraszewski, KZ1

Other Studies

8 other studies available for sk&f-38393 and Obesity

ArticleYear
Diminished natriuretic response to dopamine D1 receptor agonist, SKF-38393 in obese Zucker rats.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2003, Volume: 25, Issue:8

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Blood Glucose; Dopamine Agonist

2003
Rosiglitazone restores G-protein coupling, recruitment, and function of renal dopamine D1A receptor in obese Zucker rats.
    Hypertension (Dallas, Tex. : 1979), 2004, Volume: 43, Issue:2

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Blood Glucose; Cell Membrane; C

2004
Tempol reduces oxidative stress, improves insulin sensitivity, decreases renal dopamine D1 receptor hyperphosphorylation, and restores D1 receptor-G-protein coupling and function in obese Zucker rats.
    Diabetes, 2005, Volume: 54, Issue:7

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Blood Glucose; Cyclic N-Oxides;

2005
Mitogen-activated protein kinase upregulation reduces renal D1 receptor affinity and G-protein coupling in obese rats.
    Kidney international, 2007, Volume: 71, Issue:5

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Antioxidants; Blood Glucose; Cy

2007
Bromocriptine/SKF38393 treatment ameliorates obesity and associated metabolic dysfunctions in obese (ob/ob) mice.
    Life sciences, 1997, Volume: 61, Issue:10

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Body Composition; Body Weight;

1997
Biochemical mechanisms responsible for the attenuation of diabetic and obese conditions in ob/ob mice treated with dopaminergic agonists.
    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1999, Volume: 23, Issue:4

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adipose Tissue; Animals; Blood Glucose;

1999
Defective dopamine receptor function in proximal tubules of obese zucker rats.
    Hypertension (Dallas, Tex. : 1979), 1999, Volume: 34, Issue:5

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Dopamine; GTP-Bin

1999
Increased responsiveness of ventromedial hypothalamic neurons to norepinephrine in obese versus lean mice: relation to the metabolic syndrome.
    International journal of molecular medicine, 2000, Volume: 5, Issue:4

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Bromocriptine; Dopamine Agonist

2000